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Protein Overview: FBpp0311935, CG3...

General Information:
Name(s) found: FBpp0311935 [FlyBase]
CG3837-PA / FBpp0082463 [FlyBase]
Description(s) found:
Found 25 descriptions.
SHOW ALL
  • type=protein; loc=3R:join(10744600..10745151,10745230..10745767,10745826..10745973,10746035..10746430,10746494..10746710,10746763..10747019,10747090..10747588); ID=FBpp0311935; name=Sdr-PB; parent=FBgn0038279,FBtr0346103; dbxref=FlyBase:FBpp0311935,FlyBase_Annotation_IDs:CG3837-PB; MD5=99dff71e6a0f7c28bbbdd85e48d61caa; length=868; release=r5.56; species=Dmel; [FlyBase]
  • This gene is referred to in FlyBase by the symbol Dmel\CG3837 (CG3837, FBgn0038279). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:10744402..10748027. It has the cytological map location 88D7. Based on sequence similarity, it is predicted to have molecular function</span>: insulin-like growth factor receptor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 868 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    Biological Process: transmembrane receptor protein tyrosine kinase signaling pathway [IEA]
    protein amino acid phosphorylation [IEA]
    Molecular Function: ATP binding [IEA]
    protein binding [IEA]
    insulin-like growth factor receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGHLHPVPNP LPIPISIAVP LILLFLGASS PVLASSDDQT ACGSLEINKI ADLRKLQNCT  60
   61 HVVGHVRLAY VDLTDVSGNY SLDSLASNVT EISDYLMVYR CTGLISLQSI FPRLRIIRGQ 120
  121 ELLFDQYSLV VYENRNLREL GLVELLRIQS GFIRVESNPL LCFVETVDWI YLMGNATRQH 180
  181 FSLKHNRPQS QCPLCGSLSA DFEFIRNSSE RCWNVNTTQL RPQPPRLKDC PIACGLNGCD 240
  241 SAGKCCDHNC VTGCYSQNCS LCANYQGRMG CVNQCVASYE LNKRRCIGHR ECRELGRIPL 300
  301 IRGYQCVKKC PGNQKEILVA KGIIHCQVEC NGDFHVKSAA DLEVLQDCVT INGSLTIELT 360
  361 NIKEKIVDAL ENALASVKEI TGYLKVIHSA QLMSLTFLQN LDAIRGDKLV ENKYALYVVN 420
  421 NYHLEHIWPP NHLVIIQRGT LFFHLNPRLC YEKIHQLQGS LKSGENISVA DVSPNSNGER 480
  481 VICGDAVRSL NPKVEDLNST AVRIILDYMD WEGMETLIGY SYHYKEAPVQ NVTMYDGRHG 540
  541 CGHDNWLMDV VPNQSRRHVI SGLKPYTQYA YFVKTLTRTE YHIQIDAYSK IGYFQTLPDR 600
  601 PSPVLRIYGS SEISSQILLH WWPPRRPNGV IKNYFVTAEK YNATKEAKDK NYVNVELENA 660
  661 KDIDCECAGV LPYYSGPQPD DEDYYNKEQI TYEDALPNLI YVSRNHDYRR KEFEKVINYE 720
  721 HLLSIKKDEE PTRPPTTTPA PTNATLAKER LAAINYENYR LNSEKKQRDL QDLDQHKYTI 780
  781 RHALPKCQNS HASVVQQVEE KCVAEEPLSG YELPGTQHFY CLSQLEPETH YRITIRACVE 840
  841 GVVNGCSTPA EAVIKTASIQ LERFIKGV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..868] PSI-BLAST 112.0 No description for 2dtgE was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nitric-oxide synthase regulator activity
    		•  5.70266126834184 bayes_pls_golite062009
  • insulin-like growth factor I binding
    		•  4.32153140654108 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.21125462030555 bayes_pls_golite062009
  • insulin-like growth factor binding
    		•  4.15242171035 bayes_pls_golite062009
  • receptor activity
    		•  4.09185309744435 bayes_pls_golite062009
  • epidermal growth factor receptor activity
    		•  3.78895179350059 bayes_pls_golite062009
  • insulin-like growth factor II binding
    		•  3.78266281646447 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.24090483126624 bayes_pls_golite062009
  • signal transducer activity
    		•  3.24090483126624 bayes_pls_golite062009
  • cytokine binding
    		•  3.21238178184503 bayes_pls_golite062009
  • binding
    		•  3.12471204223368 bayes_pls_golite062009
  • growth factor binding
    		•  2.99437744892471 bayes_pls_golite062009
  • ciliary neurotrophic factor binding
    		•  2.91569341552992 bayes_pls_golite062009
  • cytokine receptor activity
    		•  2.76876397305497 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  2.41774181195462 bayes_pls_golite062009
  • interleukin-6 binding
    		•  2.41774181195462 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  2.38174370875276 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  2.32179186005318 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  1.82532222065911 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.72292771577774 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.63752021572982 bayes_pls_golite062009
  • protein tyrosine phosphatase activator activity
    		•  1.57541239141181 bayes_pls_golite062009
  • transcription activator activity
    		•  1.52459373894409 bayes_pls_golite062009
  • DNA binding
    		•  1.52455822171319 bayes_pls_golite062009
  • protein kinase activity
    		•  1.42856560840953 bayes_pls_golite062009
  • structural molecule activity
    		•  1.41012946727388 bayes_pls_golite062009
  • receptor binding
    		•  1.31676259534833 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.15899955607967 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  1.15306953094368 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.12142142875217 bayes_pls_golite062009
  • kinase activity
    		•  1.11027658115625 bayes_pls_golite062009
  • peptide hormone binding
    		•  1.03907518659462 bayes_pls_golite062009
  • cytokine receptor binding
    		•  0.93242282294581 bayes_pls_golite062009
  • oncostatin-M receptor activity
    		•  0.893795646284879 bayes_pls_golite062009
  • leukemia inhibitory factor receptor activity
    		•  0.893795646284879 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • transcription factor activity
    		•  0.846275186415624 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor binding
    		•  0.840429771743981 bayes_pls_golite062009
  • phosphatase activator activity
    		•  0.799759338745329 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.703490254739121 bayes_pls_golite062009
  • kinase binding
    		•  0.65927255037265 bayes_pls_golite062009
  • PTB domain binding
    		•  0.60680767728998 bayes_pls_golite062009
  • enzyme binding
    		•  0.60195860585095 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • growth hormone receptor activity
    		•  0.560243397322909 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.554350228628563 bayes_pls_golite062009
  • hormone binding
    		•  0.49524185948356 bayes_pls_golite062009
  • peptidase activator activity
    		•  0.47985796351505 bayes_pls_golite062009
  • peptide binding
    		•  0.47885601366674 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.46168925186147 bayes_pls_golite062009
  • heparin binding
    		•  0.45198640039153 bayes_pls_golite062009
  • transferase activity
    		•  0.432850266451294 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  0.430075899423884 bayes_pls_golite062009
  • protein-hormone receptor activity
    		•  0.42902267001067 bayes_pls_golite062009
  • protein kinase binding
    		•  0.405060010394646 bayes_pls_golite062009
  • transcription factor binding
    		•  0.293914285597849 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.27885603541101 bayes_pls_golite062009
  • interleukin-2 binding
    		•  0.240383688164201 bayes_pls_golite062009
  • cell surface binding
    		•  0.199984153958316 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.1430595594485 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • integrin binding
    		•  0.0873424694168858 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.0422160048307529 bayes_pls_golite062009
  • mercury ion binding
    		•  8.63636192294237E-5 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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