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Protein Overview: gi|74868822, gi|...

General Information:
Name(s) found: gi|74868822 [NCBI NR]
gi|24646843 [NCBI NR]
gi|23171266 [NCBI NR]
Description(s) found:
Found 9 descriptions.
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  • gi|74868822|sp|Q9VFI9.3|PDE6_DROME RecName: Full=cGMP-specific 3',5'-cyclic phosphodiesterase; AltName: Full=DmPDE5/6; Short=DmPDE6 [NCBI NR]
  • gi|24646843|ref|NP_650369.2| phosphodiesterase 6 [Drosophila melanogaster] [NCBI NR]
  • gi|23171266|gb|AAF55066.3| phosphodiesterase 6 [Drosophila melanogaster] [NCBI NR]
    • Organism: Drosophila melanogaster
    Length: 1131 amino acids

    Gene Ontology:
    Cellular Component: apical plasma membrane [IDA]
    plasma membrane [IDA]
    Biological Process: signal transduction [IEA]
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport [IMP]
    Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity [IDA][ISS]
    3',5'-cyclic-nucleotide phosphodiesterase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHGPVSRSSS SSNMTDVSSP AGGAASPVEM STTSSSSAAT TSASSSKPLT NGANKTAIST  60
   61 AAGGVTPGAV PGPGSGAIPA SSSSGNQVKL EHHHRQSNNN RPAVTNRSSE TKLMTPTGSS 120
  121 SSPSQSPSQT QASIQTQTSQ QDRLAKASTT ASQQDVDEVA RLFEEKPEAF EKWLTERAPP 180
  181 EALSRLQEFI ENRKPHKRPS VTSDLFQQWM AASPTVQQKS PRSLSNSSAS SLPECRRHLM 240
  241 DLDEGELFME LIRDVANELD IDVLCHKILV NVGLLTHADR GSLFLAKGTP TNKYLVAKLF 300
  301 DVTQKTALKD AVTRASAEEI IIPFGIGIAG MVAQTKQMIN IKEAYKDARF NCEIDLKTGY 360
  361 KTNAILCMPI CNYEGDIIGV AQIINKTNGC MEFDEHDVEI FRRYLTFCGI GIQNAQLFEM 420
  421 SVQEYRRNQI LLNLARSIFE EQNNLECLVT KIMTEARELL KCERCSVFLV DLDCCEASHL 480
  481 EKIIEKPNQP ATRAIKSADS FEEKKMRNRF TVLFELGGEY QAANVSRPSV SELSSSTLAQ 540
  541 IAQFVATTGQ TVNICDVIEW VRDHNQIRAE DEIDSTQAIL CMPIMNAQKK VIGVAQLINK 600
  601 ANGVPFTDSD ASIFEAFAIF CGLGIHNTQM YENACKLMAK QKVALECLSY HATASQDQTE 660
  661 KLTQDVIAEA ESYNLYSFTF TDFELVDDDT CRAVLRMFMQ CNLVSQFQIP YDVLCRWVLS 720
  721 VRKNYRPVKY HNWRHALNVA QTMFAMLKTG KMERFMTDLE ILGLLVACLC HDLDHRGTNN 780
  781 AFQTKTESPL AILYTTSTME HHHFDQCVMI LNSEGNNIFQ ALSPEDYRSV MKTVESAILS 840
  841 TDLAMYFKKR NAFLELVENG EFDWQGEEKK DLLCGMMMTA CDVSAIAKPW EVQHKVAKLV 900
  901 ADEFFDQGDL EKLQLNTQPV AMMDRERKDE LPKMQVGFID VICLPLYRVL CDTFPWITPL 960
  961 YEGTLENRRN WQDLAEKVEM GLTWIDHDTI DKPVEEFAAC ADEEIKDIEF TVTTLNCNQQ1020
 1021 SQHGSEDSHT PEHQRSGSRL SMKKTGALGK AVRSKLSKTL YNSMDGSKPK TSLKLLESHV1080
 1081 SEDMDDKSPT SPSQPQASGS MGRMSASSST SSAGGQMVDK SKKRSKLCAL L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..152] PSI-BLAST 3.221849 No description for 1y0fA was found.
    2 View Details [153..233] deduced N/A No confident structure predictions are available.
    3 View Details [234..652] PSI-BLAST 51.221849 3',5'-cyclic nucleotide phosphodiesterase 2A, GAF A and GAF B domains
    4 View Details [653..997] PSI-BLAST 102.0 Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Tadalafil
    5 View Details [998..1131] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • photoreceptor activity
    		•  3.2629375889808 bayes_pls_golite062009
  • binding
    		•  2.02315964268807 bayes_pls_golite062009
  • 3',5'-cyclic-GMP phosphodiesterase activity
    		•  1.71909707595169 bayes_pls_golite062009
  • signal transducer activity
    		•  1.62289915305968 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.62289915305968 bayes_pls_golite062009
  • 3',5'-cyclic-nucleotide phosphodiesterase activity
    		•  1.56682870530548 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.54732950287569 bayes_pls_golite062009
  • DNA binding
    		•  1.4095382462656 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.38037327227791 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10354038063371 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  0.974415378465889 bayes_pls_golite062009
  • cyclic-nucleotide phosphodiesterase activity
    		•  0.954654206961074 bayes_pls_golite062009
  • receptor activity
    		•  0.875023508303061 bayes_pls_golite062009
  • protein binding
    		•  0.321233885659081 bayes_pls_golite062009
    4
    Term Confidence Notes
  • 3',5'-cyclic-GMP phosphodiesterase activity
    		•  4.32481199053516 bayes_pls_golite062009
  • 3',5'-cyclic-nucleotide phosphodiesterase activity
    		•  4.15125151181381 bayes_pls_golite062009
  • cyclic-nucleotide phosphodiesterase activity
    		•  3.66153187976312 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  3.65984874547256 bayes_pls_golite062009
  • 3',5'-cyclic-AMP phosphodiesterase activity
    		•  2.18711955312275 bayes_pls_golite062009
  • hydrolase activity
    		•  1.36457789411074 bayes_pls_golite062009
  • catalytic activity
    		•  1.07048165010262 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.98531713516841 bayes_pls_golite062009
  • binding
    		•  0.783822826539632 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.511207383357891 bayes_pls_golite062009
  • protein binding
    		•  0.162314119157812 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0142153207240233 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.00598267731749835 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.00281137231762851 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.81

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle