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Protein Overview: mus308-PA

General Information:
Name(s) found: mus308-PA / FBpp0082131 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene mutagen-sensitive 308 is referred to in FlyBase by the symbol Dmel\mus308 (CG6019, FBgn0002905). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:8531245..8538021. It has the cytological map location 87C6. Based on sequence similarity, it is predicted to have molecular function</span>: DNA-directed DNA polymerase activity; helicase activity. It is reported to be involved in the biological process</span>: DNA repair. 19 alleles are reported. The phenotype of these alleles is annotated with: wing. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2059 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: DNA repair [IEA][NAS][TAS]
    DNA replication [IEA]
    Molecular Function: DNA binding [IEA]
    ATP binding [IEA]
    DNA-directed DNA polymerase activity [ISS][NAS]
    ATP-dependent helicase activity [IEA]
    helicase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFSQSFNFG NSTLMALEKG MQADDKENAQ PGNGNIQVQS AGNEVNSEIQ EINSEFFRDE  60
   61 FSYEVNQAHK PAEQSVVNVS QVQQHMAVVS NQDSEDQSRS SALNDQICTQ SSFEGEDAGA 120
  121 DAVLDQPNLD ENSFLCPAQD EEASEQLKED ILHSHSVLAK QEFYQEISQV TQNLSSMSPN 180
  181 QLRVSPNSSR IREAMPERPA MPLDLNTLRS ISAWNLPMSI QAEYKKKGVV DMFDWQVECL 240
  241 SKPRLLFEHC NLVYSAPTSA GKTLVSEILM LKTVLERGKK VLLILPFISV VREKMFYMQD 300
  301 LLTPAGYRVE GFYGGYTPPG GFESLHVAIC TIEKANSIVN KLMEQGKLET IGMVVVDEVH 360
  361 LISDKGRGYI LELLLAKILY MSRRNGLQIQ VITMSATLEN VQLLQSWLDA ELYITNYRPV 420
  421 ALKEMIKVGT VIYDHRLKLV RDVAKQKVLL KGLENDSDDV ALLCIETLLE GCSVIVFCPS 480
  481 KDWCENLAVQ LATAIHVQIK SETVLGQRLR TNLNPRAIAE VKQQLRDIPT GLDGVMSKAI 540
  541 TYACAFHHAG LTTEERDIIE ASFKAGALKV LVATSTLSSG VNLPARRVLI RSPLFGGKQM 600
  601 SSLTYRQMIG RAGRMGKDTL GESILICNEI NARMGRDLVV SELQPITSCL DMDGSTHLKR 660
  661 ALLEVISSGV ANTKEDIDFF VNCTLLSAQK AFHAKEKPPD EESDANYIND ALDFLVEYEF 720
  721 VRLQRNEERE TAVYVATRLG AACLASSMPP TDGLILFAEL QKSRRSFVLE SELHAVYLVT 780
  781 PYSVCYQLQD IDWLLYVHMW EKLSSPMKKV GELVGVRDAF LYKALRGQTK LDYKQMQIHK 840
  841 RFYIALALEE LVNETPINVV VHKYKCHRGM LQSLQQMAST FAGIVTAFCN SLQWSTLALI 900
  901 VSQFKDRLFF GIHRDLIDLM RIPDLSQKRA RALFDAGITS LVELAGADPV ELEKVLYNSI 960
  961 SFDSAKQHDH ENADEAAKRN VVRNFYITGK AGMTVSEAAK LLIGEARQFV QHEIGLGTIK1020
 1021 WTQTQAGVEI ASRAIHDGGE VDLHMSLEEE QPPVKRKLSI EENGTANSQK NPRLETVVDT1080
 1081 QRGYKVDKNI ANQSKMNPNL KEIDAQNKAR RNSTAHMDNL NPISNDPCQN NVNVKTAQPI1140
 1141 ISNLNDIQKQ GSQIEKMKIN PATVVCSPQL ANEEKPSTSQ SARRKLVNEG MAERRRVALM1200
 1201 KIQQRTQKEN QSKDQPIQAS RSNQLSSPVN RTPANRWTQS ENPNNEMNNS QLPRRNPRNQ1260
 1261 SPVPNANRTA SRKVSNAEED LFMADDSFML NTGLAAALTA AESKIASCTE ADVIPSSQPK1320
 1321 EPEVIGALTP HASRLKRSDQ LRSQRIQSPS PTPQREIEID LESKNESNGV SSMEISDMSM1380
 1381 ENPLMKNPLH LNASHIMSCS KVDETASSFS SIDIIDVCGH RNAFQAAIIE INNATRLGFS1440
 1441 VGLQAQAGKQ KPLIGSNLLI NQVAAAENRE AAARERVLFQ VDDTNFISGV SFCLADNVAY1500
 1501 YWNMQIDERA AYQGVPTPLK VQELCNLMAR KDLTLVMHDG KEQLKMLRKA IPQLKRISAK1560
 1561 LEDAKVANWL LQPDKTVNFL NMCQTFAPEC TGLANLCGSG RGYSSYGLDT SSAILPRIRT1620
 1621 AIESCVTLHI LQGQTENLSR IGNGDLLKFF HDIEMPIQLT LCQMELVGFP AQKQRLQQLY1680
 1681 QRMVAVMKKV ETKIYEQHGS RFNLGSSQAV AKVLGLHRKA KGRVTTSRQV LEKLNSPISH1740
 1741 LILGYRKLSG LLAKSIQPLM ECCQADRIHG QSITYTATGR ISMTEPNLQN VAKEFSIQVG1800
 1801 SDVVHISCRS PFMPTDESRC LLSADFCQLE MRILAHMSQD KALLEVMKSS QDLFIAIAAH1860
 1861 WNKIEESEVT QDLRNSTKQV CYGIVYGMGM RSLAESLNCS EQEARMISDQ FHQAYKGIRD1920
 1921 YTTRVVNFAR SKGFVETITG RRRYLENINS DVEHLKNQAE RQAVNSTIQG SAADIAKNAI1980
 1981 LKMEKNIERY REKLALGDNS VDLVMHLHDE LIFEVPTGKA KKIAKVLSLT MENCVKLSVP2040
 2041 LKVKLRIGRS WGEFKEVSV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..138] deduced N/A No confident structure predictions are available.
    2 View Details [139..208] PSI-BLAST 71.154902 No description for 2db3A was found.
    3 View Details [209..1040] PSI-BLAST 91.39794 No description for 2p6rA was found.
    4 View Details [1041..1132] deduced N/A No confident structure predictions are available.
    5 View Details [1133..1264] MSA 2.222997 View MSA. No confident structure predictions are available.
    6 View Details [1265..1448] MSA 3.308994 View MSA. No confident structure predictions are available.
    7 View Details [1449..2059] PSI-BLAST 1000.0 STRUCTURE OF LARGE FRAGMENT OF ESCHERICHIA COLI DNA POLYMERASE I COMPLEXED WITH D/TMP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • catalytic activity
    		•  1.37148167194523 bayes_pls_golite062009
  • hydrolase activity
    		•  1.18412998130788 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.16998111465319 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.16375481834344 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.15942143195918 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.15882580213621 bayes_pls_golite062009
  • binding
    		•  0.712909626033412 bayes_pls_golite062009
  • ATPase activity
    		•  0.62253664120117 bayes_pls_golite062009
  • helicase activity
    		•  0.00674361801283974 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7
    Term Confidence Notes
  • nuclease activity
    		•  1.81796593394339 bayes_pls_golite062009
  • exonuclease activity
    		•  1.64964907710028 bayes_pls_golite062009
  • catalytic activity
    		•  1.62277843225829 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.58702937619673 bayes_pls_golite062009
  • hydrolase activity
    		•  1.41857676124086 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.71352601607444 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  0.63299586096139 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.62821439153618 bayes_pls_golite062009
  • endonuclease activity
    		•  0.150927275899469 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle