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Protein Overview: Su(fu)-PA

General Information:
Name(s) found: Su(fu)-PA / FBpp0082134 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene Suppressor of fused is referred to in FlyBase by the symbol Dmel\Su(fu) (CG6054, FBgn0005355). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:8515595..8517434. It has the cytological map location 87C5. There is experimental evidence that it has the molecular function</span>: transcription factor binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of transcription factor activity; cytoplasmic sequestering of transcription factor; negative regulation of smoothened signaling pathway. 19 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; dorsal mesothoracic disc; antenna; axillary vein; prothoracic leg; metathoracic leg; egg chamber; wing vein; costal vein. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 468 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    protein complex [IPI]
    Hedgehog signaling complex [IPI]
    Biological Process: negative regulation of transcription factor activity [IGI]
    cytoplasmic sequestering of transcription factor [IMP]
    negative regulation of smoothened signaling pathway [IGI][NAS]
    Molecular Function: transcription factor binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEANLDKKP EVKPPPGLKA IIDHLGQVYP NQPNPLQVTT LLKYWLGGQD PLDYISMYNY  60
   61 PGDVDRNVPP HWHYISFGLS DLHGDERVHL REEGVTRSGM GFELTFRLAK TEIELKQQIE 120
  121 NPEKPQRPPT WPANLLQAIG RYCFQTGNGL CFGDNIPWRK SLDGSTTSKL QNLLVAQDPQ 180
  181 LGCIDTPTGT VDFCQIVGVF DDELEQASRW NGRGVLNFLR QDMQTGGDWL VTNMDRQMSV 240
  241 FELFPETLLN LQDDLEKQGS DLAGVNADFT FRELKPTKEV KEEVDFQALS EKCANDENNR 300
  301 QLTDTQMKRE EPSFPQSMSM SSNSLHKSCP LDFQAQAPNC ISLDGIEITL APGVAKYLLL 360
  361 AIKDRIRHGR HFTFKAQHLA LTLVAESVTG SAVTVNEPYG VLGYWIQVLI PDELVPRLME 420
  421 DFRSAGLDEK CEPKERLELE WPDKNLKLII DQPEPVLPMS LDAAPLKM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..243] PSI-BLAST 118.0 Human Suppressor of Fused (N-terminal domain)
    2 View Details [244..337] deduced N/A No confident structure predictions are available.
    3 View Details [338..468] MSA 1.01197 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  2.65237304297126 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.47003360530383 bayes_pls_golite062009
  • binding
    		•  2.41295334316774 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.84010667745013 bayes_pls_golite062009
  • protein binding
    		•  1.12780009486864 bayes_pls_golite062009
  • transcription factor binding
    		•  0.95220109251721 bayes_pls_golite062009
  • signal transducer activity
    		•  0.94580551292628 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.94580551292628 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.75239107568956 bayes_pls_golite062009
  • identical protein binding
    		•  0.162521380543051 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle