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Protein Overview: svp-PA

General Information:
Name(s) found: svp-PA / FBpp0082035 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene seven up is referred to in FlyBase by the symbol Dmel\svp (CG11502, FBgn0003651). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:8084471..8128509. It has the cytological map location 87B4-87B5. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: phototaxis; nerve-nerve synaptic transmission; cardioblast cell fate determination. 60 alleles are reported. The phenotypes of these alleles are annotated with 28 unique terms, many of which group under: external compound sense organ; peripheral nervous system; embryonic neuron; nervous system; embryonic nervous system; organ system; U neuron; compound cell cluster organ; motor neuron; embryonic hindgut. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 746 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    cytoplasm [IDA]
    Biological Process: nerve-nerve synaptic transmission [IMP]
    R1/R6 cell fate commitment [TAS]
    R7 cell fate commitment [TAS]
    cardioblast cell fate determination [IEP][IGI]
    phototaxis [IMP]
    regulation of transcription, DNA-dependent [IEA]
    R3/R4 cell fate commitment [TAS]
    regulation of transcription [ISS]
    fat body development [TAS]
    compound eye development [NAS]
    compound eye photoreceptor fate commitment [TAS]
    heart development [NAS][TAS]
    ventral cord development [TAS]
    central nervous system development [NAS]
    embryonic development via the syncytial blastoderm [NAS]
    Molecular Function: transcription factor activity [ISS]
    zinc ion binding [IEA]
    protein binding [IPI]
    ligand-dependent nuclear receptor activity [ISS][NAS]
    steroid hormone receptor activity [IEA]
    sequence-specific DNA binding [IEA]
    receptor activity [NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCASPSTAPG FFNPRPQSGA ELSAFDIGLS RSMGLGVPPH SAWHEPPASL GGHLHAASAG  60
   61 PGTTTGSVAT GGGGTTPSSV ASQQSAVIKQ DLSCPSLNQA GSGHHPGIKE DLSSSLPSAN 120
  121 GGSAGGHHSG SGSGSGSGVN PGHGSDMLPL IKGHGQDMLT SIKGQPTGCG STTPSSQANS 180
  181 SHSQSSNSGS QIDSKQNIEC VVCGDKSSGK HYGQFTCEGC KSFFKRSVRR NLTYSCRGSR 240
  241 NCPIDQHHRN QCQYCRLKKC LKMGMRREAV QRGRVPPTQP GLAGMHGQYQ IANGDPMGIA 300
  301 GFNGHSYLSS YISLLLRAEP YPTSRYGQCM QPNNIMGIDN ICELAARLLF SAVEWAKNIP 360
  361 FFPELQVTDQ VALLRLVWSE LFVLNASQCS MPLHVAPLLA AAGLHASPMA ADRVVAFMDH 420
  421 IRIFQEQVEK LKALHVDSAE YSCLKAIVLF TTGKLLDILY KDVPALLTKV SALLGKGSTA 480
  481 SNDDVLAVVR DHLDELNRQE QESQAQQQAP LHLAAFMNCV AGVEAAVQQA EQAQVPTSSA 540
  541 SASVSAPLVP SAGSAFSSCQ AKSAGSEMDL LASLYAQAQA TPPSSGGGDA SGHNNSSGLG 600
  601 ASLPTQSQSG SSSRNLTASP LSTSLATAPA PASASAPAPV PTSSVAQVPV PAPVPVTSSA 660
  661 SSSSLGGGAY QTPSAAAAAA AMFHYQTPPR AAFGSAFDMF HHSTPFGVGV GHAHALAHSS 720
  721 GSGSASFGSP SYRYSPYSLA GSRWQL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..190] MSA 7.483996 View MSA. No confident structure predictions are available.
    2 View Details [191..282] PSI-BLAST 30.39794 Retinoic acid receptor DNA-binding domain
    3 View Details [283..582] PSI-BLAST 60.0 LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA
    4 View Details [583..746] FFAS03 1.18 No description for 2j63A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.00967542385368 bayes_pls_golite062009
  • DNA binding
    		•  3.60745514727532 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.47256374293954 bayes_pls_golite062009
  • binding
    		•  2.96409924710655 bayes_pls_golite062009
  • transcription activator activity
    		•  2.9532663930699 bayes_pls_golite062009
  • transcription factor activity
    		•  2.90769972671972 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.72967350701574 bayes_pls_golite062009
  • protein binding
    		•  2.44501340584871 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.40923942043513 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.88834375049208 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.49515149729803 bayes_pls_golite062009
  • transcription factor binding
    		•  1.38523780690867 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.26452462867497 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.68943696300126 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.58115018700114 bayes_pls_golite062009
  • receptor activity
    		•  0.126253365586995 bayes_pls_golite062009
  • catalytic activity
    		•  0.101795606736461 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.0613150171780344 bayes_pls_golite062009
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.53061626347066 bayes_pls_golite062009
  • DNA binding
    		•  4.92165988569962 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.78024150262074 bayes_pls_golite062009
  • transcription activator activity
    		•  4.53302455129434 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  4.11614358606713 bayes_pls_golite062009
  • transcription factor activity
    		•  4.0914094580319 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  3.89763470197726 bayes_pls_golite062009
  • binding
    		•  3.85318710398432 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.83878598697109 bayes_pls_golite062009
  • protein binding
    		•  3.21524787168952 bayes_pls_golite062009
  • transcription factor binding
    		•  2.68044489404568 bayes_pls_golite062009
  • receptor activity
    		•  2.52514802829523 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.38308182853979 bayes_pls_golite062009
  • steroid hormone receptor activity
    		•  2.30195937604451 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.86480242237659 bayes_pls_golite062009
  • signal transducer activity
    		•  1.86480242237659 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.73827483890179 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  1.60419100774741 bayes_pls_golite062009
  • retinoic acid receptor binding
    		•  1.59968001933699 bayes_pls_golite062009
  • retinoid X receptor binding
    		•  1.45560845709347 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.34794228300778 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.23834725221597 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.995333369475571 bayes_pls_golite062009
  • retinoic acid receptor activity
    		•  0.853869057774515 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.797229273848179 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.74373733735458 bayes_pls_golite062009
  • promoter binding
    		•  0.58091332905515 bayes_pls_golite062009
  • protein N-terminus binding
    		•  0.57701453824007 bayes_pls_golite062009
  • thyroid hormone receptor activity
    		•  0.49784404390361 bayes_pls_golite062009
  • lipid binding
    		•  0.475303782949439 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.45265806678057 bayes_pls_golite062009
  • receptor binding
    		•  0.418843034756825 bayes_pls_golite062009
  • ligand-regulated transcription factor activity
    		•  0.202197503742221 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.15737167800277 bayes_pls_golite062009
  • catalytic activity
    		•  0.106902059021677 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.71

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle