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Protein Overview: Sbf-PB

General Information:
Name(s) found: Sbf-PB / FBpp0082004 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene SET domain binding factor is referred to in FlyBase by the symbol Dmel\Sbf (CG6939, FBgn0025802). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7615013..7622157. It has the cytological map location 86F8. Based on sequence similarity, it is predicted to have molecular function</span>: diacylglycerol binding; protein tyrosine/serine/threonine phosphatase activity. There is experimental evidence that it is involved in the biological process</span>: mitotic cell cycle. One allele is reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1973 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: intracellular signaling pathway [IEA]
    dephosphorylation [IEA]
    mitotic cell cycle [IMP]
    Molecular Function: diacylglycerol binding [ISS]
    protein tyrosine/serine/threonine phosphatase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRLADYFVI VGYDSDKEKT ASNVGGQPTC GKIVQRFPEK DWPDTPFIEG IEWFCQPLGW  60
   61 SLSYEKQEPK FFVSVLTDID ANKHYCACLS FHETVAITQT RSVDDEDETI GSSRLLGATP 120
  121 SSMDGITTTS TPASITHHSV MYAPKCLVLI SRLDCAETFK NCLGTIYTVY IENLAYGLET 180
  181 LIGNILGCIQ VPPAGGPQVR FSIGAGDKQS LQPPQSSSLP TTGSGVHFLF KQLGIKNVLI 240
  241 LLCSVMTENK ILFLSKCYWH LTDSCRALVA LMYPFRYTHV YIPILPAPLT EVLSTPTPFI 300
  301 MGIHSSLQTE ITDLLDVIVV DLDGGLVTIP ESLTPPVPIL PSPLWEQTQD LLSMILFPNL 360
  361 AQADLAFPTL ERPSAIAKTD AQIDKELRAI FMRLFAQLLQ GYRSCLTIIR IHPKPVITFH 420
  421 KAGFLGARDL IESEFLFRVL DSMFFTTFVN ERGPPWRSSD AWDELYSSMN ELLKSEAQNR 480
  481 NLILTHIQEL GRVLYENEGT LAHISYAQKV LRPPEGAFQR IHQPAFPRIS SEKVELIIQE 540
  541 GIRKNGVPQR FHVTRNQHRI IPMGPRLPEA LDVRPNVQNS ARRLEVLRIC VSYIFENRIT 600
  601 DARKLLPAVM RTLMHRDARL ILCREFFGYV HGNKAVLDHQ QFELVVRFMN KALQKSSGID 660
  661 EYTVAAALLP MSTIFCRKLS TGVVQFAYTE IQDHAIWKNL QFWESTFFQD VQGQIKALYL 720
  721 LHRRQNEHQK EANCVLDEVP LEEPTALEIT AEQLRKSPNI EEEKKAELAK SEESTLYSQA 780
  781 IHFANRMVSL LIPLDVNVDA ASKPKPAFRL EENQSVSNSI MGSHSLSEHS DEGFEENNAL 840
  841 EIGVTVGKTI SRFIDCVCTE GGVTSEHIRN LHDMVPGVVH MHIESLEPVY LEAKRHPHVQ 900
  901 KPKIQTPCLL PGEDLVTDHL RCFLMPDGRE DETQCLIPAE GALFLTNYRV IFKGSPCDPL 960
  961 FCEQVIVRTF PIASLLKEKK ISVLYLAHLD QTLTEGLQLR SSSFQLIKVA FDPEVTPEQI1020
 1021 ESFRKILSKA RHPFDEFEYF AFQSYGTMLQ GVAPLKTKEK YSTLKGFAKK TLLRGAKKAG1080
 1081 FKQKQQTKRK LVSDYDYGSA DAQETQSIDD ELEDGDEFET QNNAMPRLLT TKDVERMRER1140
 1141 SYVQDWKRLG FDAESQRGFR ISNANTSYAT CRSYPAIIVA PVQCSDAAIM HLGRCFKGQR1200
 1201 IPLPTWRHAN GALLIRGGQP NSKSVIGMLK NTTGSTTNAH HDVTHYPEQD KYFLALINTM1260
 1261 PKLTPLALNQ YSGMNLSMSS LMGHSSSDDR QPLTPELSRK HKNNLDISDG NKSSQGGKGG1320
 1321 TMKGNPKNSL AHPFRKMRLY ALGEKSQAKS NMNVDFCADF IPVDYPDIRQ SRPAFKKLIR1380
 1381 ACMPSHNTNE ADGQSFAKMV EQSDWLQQIS SLMQLSGAVV DLIDLQESSV MLSLEDGSDV1440
 1441 TAQLSSIAQL CLDPYYRSLD GFRVLVEKEW LAFGHRFAHR SNLKPSHANT NIAFAPTFLQ1500
 1501 FLDVVHQLQR QFPMAFEFND FYLRFLAYHS VSCRFRTFLF DCELERSDSG IAAMEDKRGS1560
 1561 LNAKHMFGAG GMATNGSDDE CSVYPLDIRS QRAPAPLNRI GHSIFDYIER QHNKTPIFYN1620
 1621 FLYSGDKSVT LRPQNNVAAL DLWCYYTNEE LAQGAPYDLE VTTVDDEIDL SETKGKRMVI1680
 1681 TAGYDNMEKC NPSAYVCLLS EVKQAETERG HLPQKWLQVW NSLEVPQLEP VARNTSLGNI1740
 1741 FVQTHQHKRS TLEIIMKGRL AGYQDKYFHP HRFEKHPYTT PTNCNHCTKL LWGPVGYRCM1800
 1801 DCGNSYHEKC TEHSMKNCTK YKAIDGAVGP PNVNMSQGDT ASIASSAATT ARTSSHHFYN1860
 1861 QFSSNVAENR THEGHLYKRG ALLKGWKQRW FVLDSIKHQL RYYDTSEDTA PKGIIELAEV1920
 1921 QSVTAAQPAQ IGAKGVDEKG FFDLKTSKRI YNFYAINANL AQEWIEKLQA CLQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..96] Pfam 26.619789 No description for PF03456.9 was found. No confident structure predictions are available.
    2 View Details [97..371] Pfam 62.136677 No description for PF02141.12 was found. No confident structure predictions are available.
    3 View Details [372..458] Pfam 28.920819 No description for PF03455.10 was found. No confident structure predictions are available.
    4 View Details [459..577] MSA 1.158995 View MSA. No confident structure predictions are available.
    5 View Details [578..672] deduced N/A No confident structure predictions are available.
    6 View Details [673..806] MSA 2.060955 View MSA. No confident structure predictions are available.
    7 View Details [807..905] deduced N/A No confident structure predictions are available.
    8 View Details [906..1002] Pfam 19.086186 No description for PF02893.11 was found. No confident structure predictions are available.
    9 View Details [1003..1650] PSI-BLAST 142.0 Crystal Structure of Myotubularin-related protein 2 complexed with phosphate
    10 View Details [1651..1852] PSI-BLAST 13.221849 Crystal Structure of the Human Beta2-Chimaerin
    11 View Details [1853..1973] PSI-BLAST 20.0 Solution Structure of the C-terminal Pleckstrin Homology Domain of Sbf1 from Mouse

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.30669036331612 bayes_pls_golite062009
  • phosphatase activity
    		•  6.53298300144214 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.34103372884365 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  5.71552511193227 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.10169989192986 bayes_pls_golite062009
  • hydrolase activity
    		•  4.27459885320933 bayes_pls_golite062009
  • transmembrane receptor protein phosphatase activity
    		•  4.08406741536367 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine phosphatase activity
    		•  4.08406741536367 bayes_pls_golite062009
  • protein tyrosine/serine/threonine phosphatase activity
    		•  2.7244435750389 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.46145625794727 bayes_pls_golite062009
  • receptor activity
    		•  2.27569467096563 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.09373043968997 bayes_pls_golite062009
  • signal transducer activity
    		•  2.09373043968997 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  1.8743338569912 bayes_pls_golite062009
  • binding
    		•  1.42026750513729 bayes_pls_golite062009
  • protein binding
    		•  1.07441758584517 bayes_pls_golite062009
  • catalytic activity
    		•  1.06283028154109 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  0.797185121839876 bayes_pls_golite062009
  • lipid phosphatase activity
    		•  0.734449638967758 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.60269333716049 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine phosphatase activity
    		•  0.594382447716896 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.440408293428823 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.368252171155074 bayes_pls_golite062009
  • potassium channel activity
    		•  0.33927808168843 bayes_pls_golite062009
  • channel activity
    		•  0.29024318255551 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.29024318255551 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.274625894373147 bayes_pls_golite062009
  • gated channel activity
    		•  0.217548650508289 bayes_pls_golite062009
  • ion channel activity
    		•  0.207688369683596 bayes_pls_golite062009
  • cation channel activity
    		•  0.125967756551725 bayes_pls_golite062009
    10
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  2.32814368667748 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.27891521507605 bayes_pls_golite062009
  • binding
    		•  2.15139804299723 bayes_pls_golite062009
  • hydrolase activity
    		•  1.91104671558756 bayes_pls_golite062009
  • phosphatase activity
    		•  1.89157568938258 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.69539294439803 bayes_pls_golite062009
  • signal transducer activity
    		•  1.5242100351394 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.5242100351394 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.49104777828784 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.48471514043683 bayes_pls_golite062009
  • protein binding
    		•  1.29100556128076 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.702565329205701 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  0.657349872289543 bayes_pls_golite062009
  • receptor binding
    		•  0.58367088800456 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.507221182248837 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.482573970055889 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.473228380405599 bayes_pls_golite062009
  • kinase activity
    		•  0.401449013594256 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.27531119327217 bayes_pls_golite062009
  • protein kinase activity
    		•  0.266851843850147 bayes_pls_golite062009
  • catalytic activity
    		•  0.194464246602439 bayes_pls_golite062009
  • lipid binding
    		•  0.12073899779791 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.0539426578243308 bayes_pls_golite062009
    11
    Term Confidence Notes
  • binding
    		•  2.65091781683225 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  2.51186557035049 bayes_pls_golite062009
  • protein binding
    		•  2.12168271674167 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  1.9018280968413 bayes_pls_golite062009
  • phosphatase activity
    		•  1.90034030060323 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.82233415659529 bayes_pls_golite062009
  • signal transducer activity
    		•  1.82233415659529 bayes_pls_golite062009
  • hydrolase activity
    		•  1.72604953071036 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.23074471235333 bayes_pls_golite062009
  • receptor activity
    		•  0.819319903902943 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.696394500650961 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.51731521446502 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  0.47102669930753 bayes_pls_golite062009
  • lipid binding
    		•  0.12933186945671 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.0787973205518102 bayes_pls_golite062009
  • receptor binding
    		•  0.0638301437766597 bayes_pls_golite062009
  • phospholipid binding
    		•  0.0143594745448499 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle