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Protein Overview: TfIIFbeta-PA

General Information:
Name(s) found: TfIIFbeta-PA / FBpp0081786 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • The gene Transcription factor TFIIFÃ?&#142;Ã?² is referred to in FlyBase by the symbol Dmel\TfIIFÃ?&#142;Ã?² (CG6538, FBgn0010421). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:6592344..6593668. It has the cytological map location 86C6. Based on sequence similarity, it is predicted to have molecular function</span>: general RNA polymerase II transcription factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: transcription initiation from RNA polymerase II promoter. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 277 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    transcription factor TFIIF complex [ISS]
    Biological Process: transcription from RNA polymerase II promoter [NAS]
    transcription initiation from RNA polymerase II promoter [ISS]
    Molecular Function: transcription initiation factor activity [NAS]
    ATP binding [IEA]
    general RNA polymerase II transcription factor activity [ISS]
    ATP-dependent helicase activity [IEA]
    ATP-dependent DNA helicase activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKEDKEKTQ IIDKDLDLSN AGRGVWLVKV PKYIAQKWEK APTNMDVGKL RINKTPGQKA  60
   61 QVSLSLTPAV LALDPEEKIP TEHILDVSQV TKQTLGVFSH MAPSDGKENS TTSAAQPDNE 120
  121 KLYMEGRIVQ KLECRPIADN CYMKLKLESI RKASEPQRRV QPIDKIVQNF KPVKDHAHNI 180
  181 EYRERKKAEG KKARDDKNAV MDMLFHAFEK HQYYNIKDLV KITNQPISYL KEILKDVCDY 240
  241 NMKNPHKNMW ELKKEYRHYK TEEKKEEEHK SGSSDSE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..137] PSI-BLAST 31.045757 TFIIF beta subunit, Rap30
    2 View Details [138..277] PSI-BLAST 26.69897 DNA-BINDING DOMAIN FROM HUMAN RAP30, NMR, MINIMIZED AVERAGE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  10.2797850053222 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  6.22439849848084 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  4.06672086326535 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.89911747857156 bayes_pls_golite062009
  • binding
    		•  2.17316238057078 bayes_pls_golite062009
  • transcription activator activity
    		•  2.12958061949296 bayes_pls_golite062009
  • protein binding
    		•  1.90482509358938 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.30173573105398 bayes_pls_golite062009
  • transcription factor binding
    		•  0.677361513203971 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.43974291826617 bayes_pls_golite062009
  • catalytic activity
    		•  0.304516551414824 bayes_pls_golite062009
    2
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  5.67074370996647 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • DNA binding
    		•  5.08959163553491 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.99681957904233 bayes_pls_golite062009
  • transcription factor activity
    		•  4.33152142980289 bayes_pls_golite062009
  • transcription activator activity
    		•  3.70589483230587 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.58179858678904 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.60738445921725 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.22485867684613 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  1.82365519759474 bayes_pls_golite062009
  • RNA polymerase activity
    		•  1.82365519759474 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  1.81270943531115 bayes_pls_golite062009
  • protein binding
    		•  1.80415286835431 bayes_pls_golite062009
  • RNA binding
    		•  0.992043085614693 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.66743181561551 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.237727660028553 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.23177057841536 bayes_pls_golite062009
  • positive transcription elongation factor activity
    		•  0.13524243942225 bayes_pls_golite062009
  • structural molecule activity
    		•  0.111941063082739 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle