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Protein Overview: Sirt6-PA

General Information:
Name(s) found: Sirt6-PA / FBpp0081719 [FlyBase]
Description(s) found:
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  • gi|7299319|gb|AAF54513.1| Sirt6 [Drosophila melanogaster] [NCBI NR]
  • gi|24645650|ref|NP_649990.1| Sirt6 [Drosophila melanogaster] [NCBI NR]
  • NAD-dependent protein deacetylase Sirt6 OS=Drosophila melanogaster GN=Sirt6 PE=2 SV=1 [Swiss-Prot]
  • The gene Sirt6 is referred to in FlyBase by the symbol Dmel\Sirt6 (CG6284, FBgn0037802). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:6086509..6087462. It has the cytological map location 86A3. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; zinc ion binding; NAD binding. There is experimental evidence that it is involved in the biological process</span>: determination of adult lifespan. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG6284-PA translation from_gene[CG6284 CG6284 FBgn0037802] seq_release:3 mol_weight=35205 cds_boundaries:(3R:6,086,530..6,087,480[-]) aa_length:317 transcript_info:[CG6284-RA seq_release:3] gene_info:[gene symbol:CG6284 FBgn0037802 gene_boundaries:(3R [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VH08) CG6284 protein [DrosMelano7227.FASTAC.txt]
  • (AE003686) CG6284 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG6284-PA [Drosophila melanogaster]gi|24645650|ref|NP_649990.1| CG6284-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(6086509..6087462); ID=FBpp0081719; name=Sirt6-PA; parent=FBgn0037802,FBtr0082242; dbxref=FlyBase:FBpp0081719,FlyBase_Annotation_IDs:CG6284-PA,GB_protein:AAF54513.1,REFSEQ:NP_649990,GB_protein:AAF54513; MD5=66377e276edb20361 [fly-100309-contam.fasta]
  • Sirt6 CG6284-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG6284-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Sirt6 [Drosophila melanogaster] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • type=protein; loc=3R:complement(6086509..6087462); ID=FBpp0081719; name=Sirt6-PA; parent=FBgn0037802,FBtr0082242; dbxref=FlyBase:FBpp0081719,FlyBase_Annotation_IDs:CG6284-PA,GB_protein:AAF54513.1,REFSEQ:NP_649990,GB_protein:AAF54513; MD5=66377e276edb2036155737ec45806081; length=317; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(6086509..6087462); ID=FBpp0081719; name=Sirt6-PA; parent=FBgn0037802,FBtr0082242; dbxref=FlyBase:FBpp0081719,FlyBase_Annotation_IDs:CG6284-PA,GB_protein:AAF54513.1,REFSEQ:NP_649990,GB_protein:AAF54513; MD5=66377e276edb2036155737ec45806081; length=317; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Sirt6 OS=Drosophila melanogaster GN=Sirt6 PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
    • Organism: Drosophila melanogaster
    Length: 317 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: determination of adult lifespan [IMP]
    protein amino acid deacetylation [IEA]
    chromatin silencing [IEA]
    regulation of transcription [IEA]
    Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [IEA]
    zinc ion binding [IEA]
    NAD binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSCNYADGLS AYDNKGILGA PESFDSDEVV AEKCQELAEL IKKSGHVVLH TGAGISTSAG  60
   61 IPDFRGPKGV WTLEEKGEKP DFNVSFDEAR PTKTHMAIIA LIESGYVQYV ISQNIDGLHL 120
  121 KSGLDRKYLS ELHGNIYIEQ CKKCRRQFVS PSAVETVGQK SLQRACKSSM DSKGRSCRSG 180
  181 ILYDNVLDWE HDLPENDLEM GVMHSTVADL NIALGTTLQI VPSGDLPLKN LKCGGKFVIC 240
  241 NLQPTKHDKK ANLIISSYVD VVLSKVCKLL GVEIPEYSEA SDPTKQSKPM EWTIPTSNVN 300
  301 TFHRQYKKYV YFIYYLL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..317] PSI-BLAST 65.09691 AF0112, Sir2 homolog (Sir2-AF2)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  1.35219834199205 bayes_pls_golite062009
  • catalytic activity
    		•  1.1096503360938 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.798062126041325 bayes_pls_golite062009
  • DNA binding
    		•  0.76914567174665 bayes_pls_golite062009
  • binding
    		•  0.725903081591757 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  0.5748958272185 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  0.5748958272185 bayes_pls_golite062009
  • histone deacetylase activity
    		•  0.417995543117071 bayes_pls_golite062009
  • protein deacetylase activity
    		•  0.40196400477198 bayes_pls_golite062009
  • deacetylase activity
    		•  0.154033944993939 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle