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View Structure Prediction Details

Protein: Sirt6-PA
Organism: Drosophila melanogaster
Length: 317 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Sirt6-PA.

Description E-value Query
Range
Subject
Range
gi|39850132, gi|... - gi|45361553|ref|NP_989353.1| sirtuin (silent mating type information regulation 2 homolog) 6 [Xenopu...
308.0 [0..1] [309..1]

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Predicted Domain #1
Region A:
Residues: [1-317]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSCNYADGLS AYDNKGILGA PESFDSDEVV AEKCQELAEL IKKSGHVVLH TGAGISTSAG  60
   61 IPDFRGPKGV WTLEEKGEKP DFNVSFDEAR PTKTHMAIIA LIESGYVQYV ISQNIDGLHL 120
  121 KSGLDRKYLS ELHGNIYIEQ CKKCRRQFVS PSAVETVGQK SLQRACKSSM DSKGRSCRSG 180
  181 ILYDNVLDWE HDLPENDLEM GVMHSTVADL NIALGTTLQI VPSGDLPLKN LKCGGKFVIC 240
  241 NLQPTKHDKK ANLIISSYVD VVLSKVCKLL GVEIPEYSEA SDPTKQSKPM EWTIPTSNVN 300
  301 TFHRQYKKYV YFIYYLL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 65.09691
Match: 1ma3A
Description: AF0112, Sir2 homolog (Sir2-AF2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 1.35219834199205 bayes_pls_golite062009
catalytic activity 1.1096503360938 bayes_pls_golite062009
nucleic acid binding 0.798062126041325 bayes_pls_golite062009
DNA binding 0.76914567174665 bayes_pls_golite062009
binding 0.725903081591757 bayes_pls_golite062009
NAD-dependent histone deacetylase activity 0.5748958272185 bayes_pls_golite062009
NAD-dependent protein deacetylase activity 0.5748958272185 bayes_pls_golite062009
histone deacetylase activity 0.417995543117071 bayes_pls_golite062009
protein deacetylase activity 0.40196400477198 bayes_pls_golite062009
deacetylase activity 0.154033944993939 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle