Protein Overview: grn-PA

General Information:
Name(s) found:	grn-PA / FBpp0081304 [FlyBase]
Description(s) found: Found 26 descriptions. SHOW ALL	The gene grain is referred to in FlyBase by the symbol Dmel\grn (CG9656, FBgn0001138). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:3973072..4007164. It has the cytological map location 84F1. Based on sequence similarity, it is predicted to have molecular function</span>: general RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: tissue development; organ morphogenesis. 12 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; embryonic abdomen; cephalopharyngeal skeleton; embryonic segment; cuticle; embryonic neuron; spiracle; pharyngeal sclerite; embryonic nervous system; integumentary specialisation. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	486 amino acids
Gene Ontology:
Cellular Component:	nucleus [ISS][NAS]
Biological Process:	regulation of transcription, DNA-dependent [IEA] tissue development [IMP][NAS] regulation of transcription from RNA polymerase II promoter [ISS] organ morphogenesis [IMP][NAS]
Molecular Function:	zinc ion binding [IEA] transcription factor activity [IEA] RNA polymerase II transcription factor activity [NAS] general RNA polymerase II transcription factor activity [ISS][NAS] sequence-specific DNA binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDMTSTAEAA ARSWYDSPRL GGGGSSGGGN GGGVSPQTNG LGSAGSSLAH SHHSLSSGAS  60
   61 SAGSSVGVGS ALGGGGGSGL DTSDMSAFYA LESNGHHRRY YPSYHQHTSR MPSTHASPQV 120
  121 CRPHFHTPLS PWLTSEHKSF APASAWSMGQ FACPQEPQVE HKLGQMGQSH QTTAAGQHSF 180
  181 PFPPTPPKDS TPDSVQTGPS EYQAVMNAFM HQQATGSTSL TDASCALDIK PSIQNGSASG 240
  241 SSGSGTTHTS TPKQREEGRE CVNCGATSTP LWRRDGTGHY LCNACGLYYK MNGQNRPLIK 300
  301 PKRRLTLQSL QSAAKRAGTS CANCKTTTTT LWRRNASGEP VCNACGLYYK LHNVNRPLTM 360
  361 KKEGIQTRNR KLSSKSKKKK GLGGGCLPIG GHLGMGDFKP LDPSKGFGGG FSASMAQHGH 420
  421 LSSGLHPAHA HMHGSWYTGG MGALGASSGL QGGFSTAGSL SGAVVPHSQP YHLGLSSMGT 480
  481 WRTDYT

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..253]	MSA	3.211995	View MSA. No confident structure predictions are available.
2	View Details	[254..317]	FFAS03	2.95	Erythroid transcription factor GATA-1
3	View Details	[318..393]	PSI-BLAST	10.69897	Erythroid transcription factor GATA-1
4	View Details	[394..486]	MSA	2.17899	View MSA. No confident structure predictions are available.

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

Term	Confidence	Notes
transcription regulator activity	3.84932768708444	bayes_pls_golite062009
DNA binding	3.45124926204188	bayes_pls_golite062009
nucleic acid binding	3.34875987514951	bayes_pls_golite062009
binding	2.8684204787273	bayes_pls_golite062009
transcription factor activity	2.74592237402384	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.23212813739998	bayes_pls_golite062009
transcription activator activity	1.45965791386122	bayes_pls_golite062009
sequence-specific DNA binding	1.44741411126911	bayes_pls_golite062009
protein binding	1.30321965120678	bayes_pls_golite062009
transcription factor binding	1.22761682002	bayes_pls_golite062009
ligand-dependent nuclear receptor activity	1.1269808729848	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.02819346233483	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.551724917261005	bayes_pls_golite062009
transcription cofactor activity	0.449959641856445	bayes_pls_golite062009
transcription repressor activity	0.199267983374872	bayes_pls_golite062009
catalytic activity	0.133319360419662	bayes_pls_golite062009

3

Term	Confidence	Notes
transcription regulator activity	4.00967542385368	bayes_pls_golite062009
DNA binding	3.60745514727532	bayes_pls_golite062009
nucleic acid binding	3.47256374293954	bayes_pls_golite062009
binding	2.96409924710655	bayes_pls_golite062009
transcription factor activity	2.90769972671972	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.40923942043513	bayes_pls_golite062009
sequence-specific DNA binding	1.62841402245495	bayes_pls_golite062009
transcription activator activity	1.62405765585032	bayes_pls_golite062009
ligand-dependent nuclear receptor activity	1.49515149729803	bayes_pls_golite062009
protein binding	1.39455913713025	bayes_pls_golite062009
transcription factor binding	1.38523780690867	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.26452462867497	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.68943696300126	bayes_pls_golite062009
transcription cofactor activity	0.58115018700114	bayes_pls_golite062009
transcription repressor activity	0.256420113528322	bayes_pls_golite062009
catalytic activity	0.101795606736461	bayes_pls_golite062009

4

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.66

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
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