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View Structure Prediction Details

Protein: grn-PA
Organism: Drosophila melanogaster
Length: 486 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for grn-PA.

Description E-value Query
Range
Subject
Range
TCNA_TRYCR - Sialidase OS=Trypanosoma cruzi GN=TCNA PE=2 SV=1
176.0 [0..2] [486..636]

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Predicted Domain #1
Region A:
Residues: [1-253]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDMTSTAEAA ARSWYDSPRL GGGGSSGGGN GGGVSPQTNG LGSAGSSLAH SHHSLSSGAS  60
   61 SAGSSVGVGS ALGGGGGSGL DTSDMSAFYA LESNGHHRRY YPSYHQHTSR MPSTHASPQV 120
  121 CRPHFHTPLS PWLTSEHKSF APASAWSMGQ FACPQEPQVE HKLGQMGQSH QTTAAGQHSF 180
  181 PFPPTPPKDS TPDSVQTGPS EYQAVMNAFM HQQATGSTSL TDASCALDIK PSIQNGSASG 240
  241 SSGSGTTHTS TPK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [254-317]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QREEGRECVN CGATSTPLWR RDGTGHYLCN ACGLYYKMNG QNRPLIKPKR RLTLQSLQSA  60
   61 AKRA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.95
Match: 2gatA
Description: Erythroid transcription factor GATA-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.84932768708444 bayes_pls_golite062009
DNA binding 3.45124926204188 bayes_pls_golite062009
nucleic acid binding 3.34875987514951 bayes_pls_golite062009
binding 2.8684204787273 bayes_pls_golite062009
transcription factor activity 2.74592237402384 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.23212813739998 bayes_pls_golite062009
transcription activator activity 1.45965791386122 bayes_pls_golite062009
sequence-specific DNA binding 1.44741411126911 bayes_pls_golite062009
protein binding 1.30321965120678 bayes_pls_golite062009
transcription factor binding 1.22761682002 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.1269808729848 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.02819346233483 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.551724917261005 bayes_pls_golite062009
transcription cofactor activity 0.449959641856445 bayes_pls_golite062009
transcription repressor activity 0.199267983374872 bayes_pls_golite062009
catalytic activity 0.133319360419662 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [318-393]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTSCANCKTT TTTLWRRNAS GEPVCNACGL YYKLHNVNRP LTMKKEGIQT RNRKLSSKSK  60
   61 KKKGLGGGCL PIGGHL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.69897
Match: 2gatA
Description: Erythroid transcription factor GATA-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.00967542385368 bayes_pls_golite062009
DNA binding 3.60745514727532 bayes_pls_golite062009
nucleic acid binding 3.47256374293954 bayes_pls_golite062009
binding 2.96409924710655 bayes_pls_golite062009
transcription factor activity 2.90769972671972 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.40923942043513 bayes_pls_golite062009
sequence-specific DNA binding 1.62841402245495 bayes_pls_golite062009
transcription activator activity 1.62405765585032 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.49515149729803 bayes_pls_golite062009
protein binding 1.39455913713025 bayes_pls_golite062009
transcription factor binding 1.38523780690867 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.26452462867497 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.68943696300126 bayes_pls_golite062009
transcription cofactor activity 0.58115018700114 bayes_pls_golite062009
transcription repressor activity 0.256420113528322 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [394-486]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GMGDFKPLDP SKGFGGGFSA SMAQHGHLSS GLHPAHAHMH GSWYTGGMGA LGASSGLQGG  60
   61 FSTAGSLSGA VVPHSQPYHL GLSSMGTWRT DYT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle