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Protein Overview: Mlp84B-PA, Mlp84B-PB

General Information:
Name(s) found: Mlp84B-PB / FBpp0081134 [FlyBase]
Mlp84B-PA / FBpp0081133 [FlyBase]
Description(s) found:
Found 47 descriptions.
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  • The gene Muscle LIM protein at 84B is referred to in FlyBase by the symbol Dmel\Mlp84B (CG1019, FBgn0014863). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:2939244..2943453. It has the cytological map location 84C1. There is experimental evidence that it has the molecular function</span>: structural constituent of muscle. There is experimental evidence that it is involved in the biological process</span>: sarcomere organization. 11 alleles are reported. The phenotype of these alleles is annotated with: pupal cuticle. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Muscle LIM protein at 84B is referred to in FlyBase by the symbol Dmel\Mlp84B (CG1019, FBgn0014863). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:2939244..2943453. It has the cytological map location 84C1. There is experimental evidence that it has the molecular function</span>: structural constituent of muscle. There is experimental evidence that it is involved in the biological process</span>: sarcomere organization. 11 alleles are reported. The phenotype of these alleles is annotated with: pupal cuticle. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 495 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS][NAS]
    Z disc [IDA]
    cytoplasm [NAS]
    Biological Process: skeletal muscle tissue development [NAS]
    cell differentiation [NAS]
    sarcomere organization [IGI]
    Molecular Function: zinc ion binding [IEA]
    protein binding [ISS]
    structural constituent of muscle [IGI][IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSFQPIEAP KCPRCGKSVY AAEERLAGGY VFHKNCFKCG MCNKSLDSTN CTEHERELYC  60
   61 KTCHGRKFGP KGYGFGTGAG TLSMDNGSQF LRENGDVPSV RNGARLEPRA IARAPEGEGC 120
  121 PRCGGYVYAA EQMLARGRSW HKECFKCGTC KKGLDSILCC EAPDKNIYCK GCYAKKFGPK 180
  181 GYGYGQGGGA LQSDCYAHDD GAPQIRAAID VDKIQARPGE GCPRCGGVVY AAEQKLSKGR 240
  241 EWHKKCFNCK DCHKTLDSIN ASDGPDRDVY CRTCYGKKWG PHGYGFACGS GFLQTDGLTE 300
  301 DQISANRPFY NPDTTSIKAR DGEGCPRCGG AVFAAEQQLS KGKVWHKKCY NCADCHRPLD 360
  361 SVLACDGPDG DIHCRACYGK LFGPKGFGYG HAPTLVSTSG ESTIQFPDGR PLAGPKTSGG 420
  421 CPRCGFAVFA AEQMISKTRI WHKRCFYCSD CRKSLDSTNL NDGPDGDIYC RACYGRNFGP 480
  481 KGVGYGLGAG ALTTF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..205] PSI-BLAST 44.522879 No description for 2i13A was found.
    2 View Details [206..348] PSI-BLAST 15.0 Ying-yang 1 (yy1, zinc finger domain)
    3 View Details [349..495] PSI-BLAST 14.39794 Five-finger GLI1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.9286072149962 bayes_pls_golite062009
  • DNA binding
    		•  2.91902554182176 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.84809232393523 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.22104591928521 bayes_pls_golite062009
  • transcription activator activity
    		•  2.18185767124518 bayes_pls_golite062009
  • protein binding
    		•  2.05530362750351 bayes_pls_golite062009
  • transcription factor activity
    		•  2.01262882344347 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.39839669257043 bayes_pls_golite062009
  • chromatin binding
    		•  1.24664529610294 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.11260773303318 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.93314267845352 bayes_pls_golite062009
  • tubulin binding
    		•  0.744315484113484 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.587070313263399 bayes_pls_golite062009
  • microtubule binding
    		•  0.576452165256057 bayes_pls_golite062009
  • metal ion binding
    		•  0.571385009230828 bayes_pls_golite062009
  • cation binding
    		•  0.571385009230828 bayes_pls_golite062009
  • ion binding
    		•  0.564805140353876 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.53991278722671 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.495045338513967 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.47431986827149 bayes_pls_golite062009
  • transcription factor binding
    		•  0.44682958253968 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle