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Protein Overview: Scr-PA, Scr-PB

General Information:
Name(s) found: Scr-PB / FBpp0089393 [FlyBase]
Scr-PA / FBpp0081163 [FlyBase]
Description(s) found:
Found 44 descriptions.
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  • The gene Sex combs reduced is referred to in FlyBase by the symbol Dmel\Scr (CG1030, FBgn0003339). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:2648842..2675886. It has the cytological map location 84A5. Based on sequence similarity, it is predicted to have molecular function</span>: specific RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: sex comb development. 99 alleles are reported. The phenotypes of these alleles are annotated with 44 unique terms, many of which group under: adult segment; embryonic segment; peripheral nervous system; thoracic segment; embryonic abdomen; mouthpart; appendage segment; nervous system; adult mesothoracic segment; external compound sense organ; antennal segment. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene Sex combs reduced is referred to in FlyBase by the symbol Dmel\Scr (CG1030, FBgn0003339). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:2648842..2675886. It has the cytological map location 84A5. Based on sequence similarity, it is predicted to have molecular function</span>: specific RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: sex comb development. 99 alleles are reported. The phenotypes of these alleles are annotated with 44 unique terms, many of which group under: adult segment; embryonic segment; peripheral nervous system; thoracic segment; embryonic abdomen; mouthpart; appendage segment; nervous system; adult mesothoracic segment; external compound sense organ; antennal segment. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 417 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: specification of segmental identity, labial segment [TAS]
    sex differentiation [TAS]
    midgut development [TAS]
    salivary gland boundary specification [NAS][TAS]
    regulation of transcription, DNA-dependent [IEA]
    sex comb development [IMP][NAS]
    regulation of transcription [IEA]
    segment specification [NAS]
    regulation of transcription from RNA polymerase II promoter [ISS]
    Molecular Function: transcription factor activity [IEA]
    specific RNA polymerase II transcription factor activity [ISS][NAS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPDCFAMSS YQFVNSLASC YPQQMNPQQN HPGAGNSSAG GSGGGAGGSG GVVPSGGTNG  60
   61 GQGSAGAATP GANDYFPAAA AYTPNLYPNT PQAHYANQAA YGGQGNPDMV DYTQLQPQRL 120
  121 LLQQQQQQQQ QQHAHAAAAV AAQQQQQLAQ QQHPQQQQQQ QQANISCKYA NDPVTPGGSG 180
  181 GGGVSGSNNN NNSANSNNNN SQSLASPQDL STRDISPKLS PSSVVESVAR SLNKGVLGGS 240
  241 LAAAAAAAGL NNNHSGSGVS GGPGNVNVPM HSPGGGDSDS ESDSGNEAGS SQNSGNGKKN 300
  301 PPQIYPWMKR VHLGTSTVNA NGETKRQRTS YTRYQTLELE KEFHFNRYLT RRRRIEIAHA 360
  361 LCLTERQIKI WFQNRRMKWK KEHKMASMNI VPYHMGPYGH PYHQFDIHPS QFAHLSA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..132] PSI-BLAST 3.69897 Sec24
    2 View Details [133..322] deduced N/A No confident structure predictions are available.
    3 View Details [323..417] PSI-BLAST 22.154902 DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle