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Protein Overview: Dfd-PA

General Information:
Name(s) found: Dfd-PA / FBpp0081138 [FlyBase]
Description(s) found:
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  • gi|68067431|sp|P07548.2|DFD_DROME RecName: Full=Homeotic protein deformed [NCBI NR]
  • gi|4389426|gb|AAD19796.1| homeodomain protein [Drosophila melanogaster] [NCBI NR]
  • gi|23170614|gb|AAF54083.2| deformed [Drosophila melanogaster] [NCBI NR]
  • gi|17137270|ref|NP_477201.1| deformed [Drosophila melanogaster] [NCBI NR]
  • Homeotic protein deformed OS=Drosophila melanogaster GN=Dfd PE=1 SV=2 [Swiss-Prot]
  • The gene Deformed is referred to in FlyBase by the symbol Dmel\Dfd (CG2189, FBgn0000439). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:2617558..2628153. It has the cytological map location 84A5. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process</span>: embryonic morphogenesis; embryonic development; brain development; induction of apoptosis. 41 alleles are reported. The phenotypes of these alleles are annotated with 36 unique terms, many of which group under: embryonic segment; organ system; nervous system; peripheral nervous system; thoracic segment; cephalopharyngeal skeleton; external compound sense organ; cuticle; multi-cell-component structure; adult brain; antennal segment; mouthpart. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG2189-PA translation from_gene[CG2189 Dfd FBgn0000439] seq_release:3 mol_weight=63381 cds_boundaries:(3R:2,618,048..2,627,659[+]) aa_length:586 transcript_info:[CG2189-RA seq_release:3] gene_info:[gene symbol:Dfd FBgn0000439 gene_boundaries:(3R:2,617 [hmr_yeast5_DM3-1_pombe.fasta]
  • CG2189-PA [Drosophila melanogaster]gi|17137270|ref|NP_477201.1| CG2189-PA [Drosophila melanogaster]gi|4389426|gb|AAD19796.1| homeodomain protein [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(2618047..2618833,2619219..2619319,2619385..2619562,2626701..2627080,2627347..2627661); ID=FBpp0081138; name=Dfd-PA; parent=FBgn0000439,FBtr0081621; dbxref=FlyBase:FBpp0081138,FlyBase_Annotation_IDs:CG2189-PA,GB_protein:AAF54083.2 [fly-100309-contam.fasta]
  • Deformed CG2189-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG2189-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Homeotic protein deformed [nr-271106-contam.fasta]
  • homeodomain protein [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(2618047..2618833,2619219..2619319,2619385..2619562,2626701..2627080,2627347..2627661); ID=FBpp0081138; name=Dfd-PA; parent=FBgn0000439,FBtr0081621; dbxref=FlyBase:FBpp0081138,FlyBase_Annotation_IDs:CG2189-PA,GB_protein:AAF54083.2,REFSEQ:NP_477201,GB_protein:AAF54083; MD5=2087d9d4c3be6f981c3fdb4a473e896c; length=586; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(2618047..2618833,2619219..2619319,2619385..2619562,2626701..2627080,2627347..2627661); ID=FBpp0081138; name=Dfd-PA; parent=FBgn0000439,FBtr0081621; dbxref=FlyBase:FBpp0081138,FlyBase_Annotation_IDs:CG2189-PA,GB_protein:AAF54083.2,REFSEQ:NP_477201,GB_protein:AAF54083; MD5=2087d9d4c3be6f981c3fdb4a473e896c; length=586; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:join(2618047..2618833,2619219..2619319,2619385..2619562,2626701..2627080,2627347..2627661); ID=FBpp0081138; name=Dfd-PA; parent=FBgn0000439,FBtr0081621; dbxref=FlyBase:FBpp0081138,FlyBase_Annotation_IDs:CG2189-PA,GB_protein:AAF54083.2,REFSEQ:NP_477201,GB_protein:AAF54083,FlyMine:FBpp0081138,modMine:FBpp0081138; MD5=2087d9d4c3be6f981c3fdb4a473e896c; length=586; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:join(6792325..6793111,6793497..6793597,6793663..6793840,6800979..6801358,6801625..6801939); ID=FBpp0081138; name=Dfd-PA; parent=FBgn0000439,FBtr0081621; dbxref=FlyBase:FBpp0081138,FlyBase_Annotation_IDs:CG2189-PA,GB_protein:AAF54083.2,REFSEQ:NP_477201,GB_protein:AAF54083,FlyMine:FBpp0081138,modMine:FBpp0081138; MD5=2087d9d4c3be6f981c3fdb4a473e896c; length=586; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(6792325..6793111,6793497..6793597,6793663..6793840,6800979..6801358,6801625..6801939); ID=FBpp0081138; name=Dfd-PA; parent=FBgn0000439,FBtr0081621; dbxref=FlyBase:FBpp0081138,FlyBase_Annotation_IDs:CG2189-PA,GB_protein:AAF54083.2,REFSEQ:NP_477201,GB_protein:AAF54083,FlyMine:FBpp0081138,modMine:FBpp0081138; MD5=2087d9d4c3be6f981c3fdb4a473e896c; length=586; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0081138 type=protein; loc=3R:join(6792325..6793111,6793497..6793597,6793663..6793840,6800979..6801358,6801625..6801939); ID=FBpp0081138; name=Dfd-PA; parent=FBgn0000439,FBtr0081621; dbxref=FlyBase:FBpp0081138,FlyBase_Annotation_IDs:CG2189-PA,GB_protein:AAF54083.2,REFSEQ:NP_477201,GB_protein:AAF54083,FlyMine:FBpp0081138,modMine:FBpp0081138; MD5=2087d9d4c3be6f981c3fdb4a473e896c; length=586; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(6792325..6793111,6793497..6793597,6793663..6793840,6800979..6801358,6801625..6801939); ID=FBpp0081138; name=Dfd-PA; parent=FBgn0000439,FBtr0081621; dbxref=FlyBase:FBpp0081138,FlyBase_Annotation_IDs:CG2189-PA,GB_protein:AAF54083.2,REFSEQ:NP_477201,GB_protein:AAF54083,UniProt/Swiss-Prot:P07548,FlyMine:FBpp0081138,modMine:FBpp0081138; MD5=2087d9d4c3be6f981c3fdb4a473e896c; length=586; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 586 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA][NAS]
    Biological Process: embryonic development [IMP]
    specification of segmental identity, head [NAS]
    embryonic morphogenesis [IMP]
    induction of apoptosis [IGI][IMP]
    regulation of transcription, DNA-dependent [IEA]
    brain development [IMP]
    regulation of transcription [IEA]
    Molecular Function: transcription factor activity [IEA][NAS][TAS]
    RNA polymerase II transcription factor activity [NAS]
    sequence-specific DNA binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSFLMGYPH APHHVQSPMS MGNGLDPKFP PLADDYHHYN GHYSMTASTG HMSGAVGGGA  60
   61 GVGSVGGGGA GGMTGHPHSM HPADMVSDYM AHHHNPHSHS HSHTHSLPHH HSNSAISGHH 120
  121 QASAGGYSSN YANATPPSHP HSHPHAHPHQ SLGYYVHHAP EFISAGAVHS DPTNGYGPAA 180
  181 NVPNTSNGGG GGGSGAVLGG GAVGGSANGY YGGYGGGYGT ANGSVGSTHS QGHSPHSQMM 240
  241 DLPLQCSSTE PPTNTALGLQ ELGLKLEKRI EEAVPAGQQL QELGMRLRCD DMGSENDDMS 300
  301 EEDRLMLDRS PDELGSNDND DDLGDSDSDE DLMAETTDGE RIIYPWMKKI HVAGVANGSY 360
  361 QPGMEPKRQR TAYTRHQILE LEKEFHYNRY LTRRRRIEIA HTLVLSERQI KIWFQNRRMK 420
  421 WKKDNKLPNT KNVRKKTVDA NGNPTPVAKK PTKRAASKKQ QQAQQQQQSQ QQQTQQTPVM 480
  481 NECIRSDSLE SIGDVSSSLG NPPYIPAAPE TTSSYPGSQQ HLSNNNNNGS GNNNNNNNNN 540
  541 NSNLNNNNNN NQMGHTNLHG HLQQQQSDLM TNLQLHIKQD YDLTAL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..161] MSA 8.181996 View MSA. No confident structure predictions are available.
    2 View Details [162..364] deduced N/A No confident structure predictions are available.
    3 View Details [365..441] PSI-BLAST 21.522879 DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
    4 View Details [442..586] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  4.20302368446064 bayes_pls_golite062009
  • DNA binding
    		•  3.910335137985 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.70444192553266 bayes_pls_golite062009
  • transcription factor activity
    		•  3.41495638905535 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.0896307866191 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.72533206529661 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.55910796763122 bayes_pls_golite062009
  • transcription activator activity
    		•  1.36535925881104 bayes_pls_golite062009
  • transcription factor binding
    		•  1.05399367242529 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.7265140277161 bayes_pls_golite062009
  • chromatin binding
    		•  0.572427333286789 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.49703800163515 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.65

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle