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View Structure Prediction Details

Protein: Dfd-PA
Organism: Drosophila melanogaster
Length: 586 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dfd-PA.

Description E-value Query
Range
Subject
Range
gi|7837, gi|8492... - pir||A26638 homeotic protein Dfd - fruit fly (Drosophila melanogaster), gi|7837|emb|CAA28782.1| unn...
164.0 [0..1] [586..1]

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Predicted Domain #1
Region A:
Residues: [1-161]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSFLMGYPH APHHVQSPMS MGNGLDPKFP PLADDYHHYN GHYSMTASTG HMSGAVGGGA  60
   61 GVGSVGGGGA GGMTGHPHSM HPADMVSDYM AHHHNPHSHS HSHTHSLPHH HSNSAISGHH 120
  121 QASAGGYSSN YANATPPSHP HSHPHAHPHQ SLGYYVHHAP E

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [162-364]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FISAGAVHSD PTNGYGPAAN VPNTSNGGGG GGSGAVLGGG AVGGSANGYY GGYGGGYGTA  60
   61 NGSVGSTHSQ GHSPHSQMMD LPLQCSSTEP PTNTALGLQE LGLKLEKRIE EAVPAGQQLQ 120
  121 ELGMRLRCDD MGSENDDMSE EDRLMLDRSP DELGSNDNDD DLGDSDSDED LMAETTDGER 180
  181 IIYPWMKKIH VAGVANGSYQ PGM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [365-441]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPKRQRTAYT RHQILELEKE FHYNRYLTRR RRIEIAHTLV LSERQIKIWF QNRRMKWKKD  60
   61 NKLPNTKNVR KKTVDAN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.522879
Match: 1homA
Description: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.20302368446064 bayes_pls_golite062009
DNA binding 3.910335137985 bayes_pls_golite062009
nucleic acid binding 3.70444192553266 bayes_pls_golite062009
transcription factor activity 3.41495638905535 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.0896307866191 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.72533206529661 bayes_pls_golite062009
transcription repressor activity 1.55910796763122 bayes_pls_golite062009
transcription activator activity 1.36535925881104 bayes_pls_golite062009
transcription factor binding 1.05399367242529 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.7265140277161 bayes_pls_golite062009
chromatin binding 0.572427333286789 bayes_pls_golite062009
transcription cofactor activity 0.49703800163515 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [442-586]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNPTPVAKKP TKRAASKKQQ QAQQQQQSQQ QQTQQTPVMN ECIRSDSLES IGDVSSSLGN  60
   61 PPYIPAAPET TSSYPGSQQH LSNNNNNGSG NNNNNNNNNN SNLNNNNNNN QMGHTNLHGH 120
  121 LQQQQSDLMT NLQLHIKQDY DLTAL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle