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Protein Overview: bcd-PG

General Information:
Name(s) found: bcd-PG / FBpp0081168 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene bicoid is referred to in FlyBase by the symbol Dmel\bcd (CG1034, FBgn0000166). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:2581564..2585199. It has the cytological map location 84A5. There is experimental evidence that it has the molecular function</span>: protein binding; SUMO binding; RNA polymerase II transcription factor activity, enhancer binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of gene-specific transcription from RNA polymerase II promoter; oogenesis; segment polarity determination; anterior region determination. 416 alleles are reported. The phenotypes of these alleles are annotated with 51 unique terms, many of which group under: embryonic segment; embryonic abdomen; organ system; abdominal ventral denticle belt; cephalopharyngeal skeleton; thoracic segment; cuticle; pharyngeal sclerite; spiracle; extended germ band embryo. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 494 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][IEA][NAS]
    Biological Process: regulation of translation [TAS]
    anterior/posterior axis specification [TAS]
    anterior/posterior axis specification, embryo [NAS][TAS]
    oogenesis [IMP]
    anterior region determination [IMP]
    regulation of transcription, DNA-dependent [IEA][NAS]
    segment polarity determination [IMP]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [IDA]
    regulation of transcription [IEA]
    negative regulation of translation [TAS]
    maternal determination of anterior/posterior axis, embryo [NAS][TAS]
    regulation of transcription from RNA polymerase II promoter [NAS]
    Molecular Function: SUMO binding [IPI]
    translation regulator activity [TAS]
    protein binding [IPI]
    specific RNA polymerase II transcription factor activity [NAS]
    RNA polymerase II transcription factor activity, enhancer binding [IDA]
    sequence-specific DNA binding [IEA]
    morphogen activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQPPPDQNF YHHPLPHTHT HPHPHSHPHP HSHPHPHHQH PQLQLPPQFR NPFDLLFDER  60
   61 TGAINYNYIR PYLPNQMPKP DVFPSEELPD SLVMRRPRRT RTTFTSSQIA ELEQHFLQGR 120
  121 YLTAPRLADL SAKLALGTAQ VKIWFKNRRR RHKIQSDQHK DQSYEGMPLS PGMKQSDGDP 180
  181 PSLQTLSLGG GATPNALTPS PTPSTPTAHM TEHYSESFNA YYNYNGGHNH AQANRHMHMQ 240
  241 YPSGGGPGPG STNVNGGQFF QQQQVHNHQQ QLHHQGNHVP HQMQQQQQQA QQQQYHHFDF 300
  301 QQKQASACRV LVKDEPEADY NFNSSYYMRS GMSGATASAS AVARGAASPG SEVYEPLTPK 360
  361 NDESPSLCGI GIGGPCAIAV GETEAADDMD DGTSKKTTLQ ILEPLKGLDK SCDDGSSDDM 420
  421 STGIRALAGT GNRGAAFAKF GKPSPPQGPQ PPLGMGGVAM GESNQYQCTM DTIMQAYNPH 480
  481 RNAAGNSQFA YCFN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..84] deduced N/A No confident structure predictions are available.
    2 View Details [85..160] PSI-BLAST 12.69897 NMR Solution Structure of the Bicoid Homeodomain Bound to the Consensus DNA Binding Site TAATCC
    3 View Details [161..320] deduced N/A No confident structure predictions are available.
    4 View Details [321..494] MSA 4.178995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.5139760613123 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.29590968570638 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • transcription activator activity
    		•  3.10621734076555 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.28746845122519 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle