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Protein Overview: opa-PA

General Information:
Name(s) found: opa-PA / FBpp0078477 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene odd paired is referred to in FlyBase by the symbol Dmel\opa (CG1133, FBgn0003002). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:678535..695709. It has the cytological map location 82D8-82E1. Based on sequence similarity, it is predicted to have molecular function</span>: specific RNA polymerase II transcription factor activity; transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: decapentaplegic receptor signaling pathway; eye-antennal disc morphogenesis; germ cell migration; midgut development. 40 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: organ system; anatomical structure; primordium; embryonic segment; late extended germ band embryo; cuticle; imaginal precursor; extended germ band embryo; midgut constriction; embryonic heart; external compound sense organ; antennal segment. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 609 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: midgut development [IEP][IMP]
    eye-antennal disc morphogenesis [IMP]
    germ cell migration [IMP]
    periodic partitioning [NAS]
    decapentaplegic receptor signaling pathway [IMP]
    regulation of transcription from RNA polymerase II promoter [ISS]
    Molecular Function: transcription factor activity [ISS]
    zinc ion binding [IEA]
    specific RNA polymerase II transcription factor activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMMNAFIEPA QHHLASYGLR MSPNTTASNS NAQQQQQQQL EMTQQQQQQQ QQQQQQQQQD  60
   61 QESAAATAAA YQNSGYGHFN SYASRDFLLG RREAEYGVAG SAGQASAAAD SMLFSGFPAQ 120
  121 AAELGSGFGQ HPFHSHHHHH QMRMGMADAY AAGHPYNHHG NFPTAAVHHP VVHHPSHHAM 180
  181 SAMHPAGAGA FLRYMRHQPA SSASSVKQEM QCLWIDPDQP GLVPPGGRKT CNKVFHSMHE 240
  241 IVTHLTVEHV GGPECTTHAC FWVGCSRNGR PFKAKYKLVN HIRVHTGEKP FACPHPGCGK 300
  301 VFARSENLKI HKRTHTGEKP FKCEHEGCDR RFANSSDRKK HSHVHTSDKP YNCRINGCDK 360
  361 SYTHPSSLRK HMKVHGNVDE KSPSHGYDSE GEESSSSSII TGGAQTPPST RLDGSAGSSS 420
  421 GVSSLSGGSG IKSSPHSIKS EPNPMHSVHL GASSSGSSST ASSSASHLLQ HQQHQHQQQQ 480
  481 QQQQHQQQAQ QQQQLTAHPS DPKSSPALQL MAASASAYLP PPLGPPPSHH HHPHHHQAAP 540
  541 SPGAAAASAS MLHHNHHLLY HPAAQHHPPS DWYHTTAPSG SAEAMNPLNH FGHHHHHHHL 600
  601 MHPGAATAY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..92] deduced N/A No confident structure predictions are available.
    2 View Details [93..172] PSI-BLAST 17.39794 TATA box-binding zinc finger, TATAZF
    3 View Details [173..394] PSI-BLAST 26.30103 Five-finger GLI1
    4 View Details [395..609] PSI-BLAST 58.30103 No description for 2i13A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  4.70988788192472 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.58713908116892 bayes_pls_golite062009
  • DNA binding
    		•  4.56219307357342 bayes_pls_golite062009
  • transcription factor activity
    		•  3.50954949535763 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22082323675675 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • transcription activator activity
    		•  2.19952417915035 bayes_pls_golite062009
  • chromatin binding
    		•  2.18464662431232 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.64349785387632 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.63161912031789 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.42975942698743 bayes_pls_golite062009
  • transcription factor binding
    		•  1.39608963544799 bayes_pls_golite062009
  • protein binding
    		•  1.00484935878505 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.77874411480713 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.10558148421807 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle