Protein Overview: Jafrac2-PA, Jafr...

General Information:
Name(s) found:	FBpp0304422 [FlyBase] Jafrac2-PB / FBpp0072853 [FlyBase] Jafrac2-PA / FBpp0072852 [FlyBase]
Description(s) found: Found 45 descriptions. SHOW ALL	type=protein; loc=3L:join(3043052..3043205,3043272..3043389,3043441..3043846,3043905..3043955); ID=FBpp0304422; name=Jafrac2-PC; parent=FBgn0040308,FBtr0332112; dbxref=FlyBase:FBpp0304422,FlyBase_Annotation_IDs:CG1274-PC,REFSEQ:NP_001261350,GB_protein:AGB94045; MD5=0d3cc713f2fcae21773c80acaf471d70; length=242; release=r5.56; species=Dmel; [FlyBase] The gene thioredoxin peroxidase 2 is referred to in FlyBase by the symbol Dmel\Jafrac2 (CG1274, FBgn0040308). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:3042375..3044174. It has the cytological map location 63A3. There is experimental evidence that it has the molecular function</span>: thioredoxin peroxidase activity. There is experimental evidence that it is involved in the biological process</span>: induction of apoptosis; cellular response to DNA damage stimulus; hydrogen peroxide catabolic process. 9 alleles are reported. The phenotype of these alleles is annotated with: eye. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] The gene thioredoxin peroxidase 2 is referred to in FlyBase by the symbol Dmel\Jafrac2 (CG1274, FBgn0040308). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:3042375..3044174. It has the cytological map location 63A3. There is experimental evidence that it has the molecular function</span>: thioredoxin peroxidase activity. There is experimental evidence that it is involved in the biological process</span>: induction of apoptosis; cellular response to DNA damage stimulus; hydrogen peroxide catabolic process. 9 alleles are reported. The phenotype of these alleles is annotated with: eye. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	242 amino acids
Gene Ontology:
Cellular Component:	extracellular region [IDA][NAS]
Biological Process:	induction of apoptosis [IGI][IMP][IPI] apoptosis [TAS] cell redox homeostasis [IEA] response to DNA damage stimulus [IMP] hydrogen peroxide catabolic process [IDA]
Molecular Function:	peroxidase activity [NAS] antioxidant activity [ISS][NAS] thioredoxin peroxidase activity [IDA][ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKYLSVLLL SAALVGAAKP EDNESCYSFA GGSVYPDQPK GDHQLQYTKA VISKPAPQFE  60
   61 GTAVVNKEIV KLSLSQYLGK YVVLLFYPLD FTFVCPTEII AFSDRIAEFK KIKTEVIGVS 120
  121 VDSHFTHLAW INTPRKEGGL GDVKIPLLSD LTHKISKDYG VYLESSGHAL RGLFIIDQTG 180
  181 VLRQITMNDL PVGRSVDETI RLVQAFQYTD THGEVCPAGW RPGADTIVPN PEEKTKYFAK 240
  241 NN

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

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Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
alkyl hydroperoxide reductase activity	4.29610283853788	bayes_pls_golite062009
antioxidant activity	3.8464796631544	bayes_pls_golite062009
peroxidase activity	3.43831566988273	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	3.43831566988273	bayes_pls_golite062009
selenium binding	2.92496040718744	bayes_pls_golite062009
glutathione peroxidase activity	2.56524997297011	bayes_pls_golite062009
transcription regulator activity	2.30799114442278	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	2.23310780102446	bayes_pls_golite062009
peroxiredoxin activity	2.12777217096121	bayes_pls_golite062009
thioredoxin peroxidase activity	1.96134566495756	bayes_pls_golite062009
protein disulfide oxidoreductase activity	1.47769936616412	bayes_pls_golite062009
disulfide oxidoreductase activity	1.32811008894503	bayes_pls_golite062009
binding	1.25802922431343	bayes_pls_golite062009
protein binding	1.18479617596618	bayes_pls_golite062009
molecular transducer activity	1.11518182894524	bayes_pls_golite062009
signal transducer activity	1.11518182894524	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009
peptide binding	0.374493676068876	bayes_pls_golite062009
	0.359224524631956	bayes_pls_golite062009
NADH dehydrogenase activity	0.23291471505999	bayes_pls_golite062009
copper ion binding	0.178842772364502	bayes_pls_golite062009
NADH dehydrogenase (ubiquinone) activity	0.16328723676608	bayes_pls_golite062009
NADH dehydrogenase (quinone) activity	0.0434052164026002	bayes_pls_golite062009

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..242]	PSI-BLAST	66.69897	Thioredoxin peroxidase 2 (thioredoxin peroxidase B, 2-cys peroxiredoxin)

Protein Overview: Jafrac2-PA, Jafr...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: