Protein Overview: pain-PA

General Information:
Name(s) found:	pain-PA / FBpp0072323 [FlyBase]
Description(s) found: Found 25 descriptions. SHOW ALL	The gene painless is referred to in FlyBase by the symbol Dmel\pain (CG15860, FBgn0060296). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:20809028..20815794. It has the cytological map location 60E5. Based on sequence similarity, it is predicted to have molecular function</span>: calcium channel activity. There is experimental evidence that it is involved in the biological process</span>: feeding behavior; sensory perception of pain. 13 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	913 amino acids
Gene Ontology:
Cellular Component:	membrane [IEA] integral to membrane [NAS]
Biological Process:	response to heat [TAS] ion transport [IEA] regulation of female receptivity [IMP] transmembrane transport [IEA] [NOT]thermotaxis [IMP] calcium ion transport [ISS] sensory perception of pain [IMP][NAS] feeding behavior [IMP] copulation [IMP] response to mechanical stimulus [NAS] detection of mechanical stimulus involved in sensory perception [TAS]
Molecular Function:	ion channel activity [IEA][TAS] calcium channel activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFNNCGFID PQAQLAGALA KQDIRQFVAA LDSGALADLQ DDRHTSIYEK ALSTPGCRDF  60
   61 IEACIDHGSQ VNYINKKLDK AAISYAADSR DPGNLAALLK YRPGNKVQVD RKYGQLTPLN 120
  121 SLAKNLTDEN APDVYSCMQL LLDYGASPNI VDQGEFTPLH HVLRKSKVKA GKKELIQLFL 180
  181 DHPELDIDSY RNGEVRRLLQ AQFPELKLPE ERHTGPEIDI QTLQRTLRDG DETLFEQQFA 240
  241 EYLQNLKGGA DNQLNAHQEE YFGLLQESIK RGRQRAFDVI LSTGMDINSR PGRANEANLV 300
  301 ETAVIYGNWQ ALERLLKEPN LRLTPDSKLL NAVIGRLDEP PYDGSSHQRC FELLINSDRV 360
  361 DINEADSGRL VPLFFAVKYR NTSAMQKLLK NGAYIGSKSA FGTLPIKDMP PEVLEEHFDS 420
  421 CITTNGERPG DQNFEIIIDY KNLMRQERDS GLNQLQDEMA PIAFIAESKE MRHLLQHPLI 480
  481 SSFLFLKWHR LSVIFYLNFL IYSLFTASII TYTLLKFHES DQRALTAFFG LLSWLGISYL 540
  541 ILRECIQWIM SPVRYFWSIT NIMEVALITL SIFTCMESSF DKETQRVLAV FTILLVSMEF 600
  601 CLLVGSLPVL SISTHMLMLR EVSNSFLKSF TLYSIFVLTF SLCFYILFGK SVEEDQSKSA 660
  661 TPCPPLGKKE GKDEEQGFNT FTKPIEAVIK TIVMLTGEFD AGSIQFTSIY TYLIFLLFVI 720
  721 FMTIVLFNLL NGLAVSDTQV IKAQAELNGA ICRTNVLSRY EQVLTGHGRA GFLLGNHLFR 780
  781 SICQRLMNIY PNYLSLRQIS VLPNDGNKVL IPMSDPFEMR TLKKASFQQL PLSAAVPQKK 840
  841 LLDPPLRLLP CCCSLLTGKC SQMSGRVVKR ALEVIDQKNA AEQRRKQEQI NDSRLKLIEY 900
  901 KLEQLIQLVQ DRK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
metal ion transmembrane transporter activity	3.06689459321273	bayes_pls_golite062009
ion transmembrane transporter activity	2.89029061890648	bayes_pls_golite062009
cation transmembrane transporter activity	2.66479899929908	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.59441577402651	bayes_pls_golite062009
calcium channel activity	2.42383730626707	bayes_pls_golite062009
mechanically-gated ion channel activity	2.39992943698319	bayes_pls_golite062009
mechanically gated channel activity	2.39992943698319	bayes_pls_golite062009
channel activity	2.39688396372487	bayes_pls_golite062009
passive transmembrane transporter activity	2.39688396372487	bayes_pls_golite062009
cation channel activity	2.37772481426745	bayes_pls_golite062009
ion channel activity	2.36752848265558	bayes_pls_golite062009
substrate-specific channel activity	2.26531840012081	bayes_pls_golite062009
gated channel activity	1.75472864911207	bayes_pls_golite062009
protein binding	1.62940095931841	bayes_pls_golite062009
binding	1.48463036580652	bayes_pls_golite062009
transporter activity	1.19000052859754	bayes_pls_golite062009
transmembrane transporter activity	1.02570255606772	bayes_pls_golite062009
substrate-specific transporter activity	0.835937200249181	bayes_pls_golite062009
receptor activity	0.415279977682022	bayes_pls_golite062009
signal transducer activity	0.143078152901993	bayes_pls_golite062009
molecular transducer activity	0.143078152901993	bayes_pls_golite062009
transmembrane receptor activity	0.124764997485166	bayes_pls_golite062009

No functions predicted.

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..455]	PSI-BLAST	91.69897	Ankyrin-R
2	View Details	[456..753]	PSI-BLAST	17.30103	Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
3	View Details	[754..913]	deduced	N/A	No confident structure predictions are available.

Protein Overview: pain-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: