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Protein Overview: mr-PA

General Information:
Name(s) found: mr-PA / FBpp0072065 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene morula is referred to in FlyBase by the symbol Dmel\mr (CG3060, FBgn0002791). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:19859956..19862935. It has the cytological map location 60A15. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: ubiquitin protein ligase binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of synaptic growth at neuromuscular junction; regulation of synaptic transmission. 16 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: organ system; anatomical structure; female germline cyst; egg; nervous system; cell component; endocrine system; external compound sense organ; adult segment; adult; imaginal precursor; peripheral nervous system. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 802 amino acids

    Gene Ontology:
    Cellular Component: cullin-RING ubiquitin ligase complex [IEA]
    anaphase-promoting complex [NAS][TAS]
    Biological Process: negative regulation of synaptic growth at neuromuscular junction [IMP]
    regulation of synaptic transmission [IMP]
    mitotic anaphase [NAS]
    regulation of cell cycle [TAS]
    ubiquitin-dependent protein catabolic process [IEA]
    Molecular Function: ubiquitin protein ligase binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCDFDALWAD VLRIFPVLGG ANAVSNDPVE ENVFQNVRQH LMVLGSIDTF AAVVDLEIQS  60
   61 TIRNVLVPKF WKHIHDGLVS SKLQGWINDQ ALAIEALPDK NGLFTQFIDA INELHDSFQS 120
  121 LMQVKPRLIQ LVGAETKPTA KTVKLMQEEG IKNCLRDCLL AQLPPNFSVV VGAFYWVHFK 180
  181 LFTKASNLAL TTVDSDVFDE LLCVGCNFEA EQCCCQRLTD MVNKTNMKLF EMNLIDRLTG 240
  241 SALTALIKLK IKEHISDTCM GIFDRSHLKQ LETWLSDVIM SWLTNIFTEW KSKDSISDIE 300
  301 VPESVKSFKV KLTYFMYETF AQSVIGQFFS IIIDYPDSIP AIDDLKICME KIDMRVYLTE 360
  361 SLRNSLEARI LHPGVNTMDI LTGYVAAIKA IRHLDSTGVI LEMVTAPIKD YLRKRNDTVR 420
  421 RVVTGLTEEG PTDLSEELAK GETIKECKDS GTDEFSNWEN WQPDPFGIDA SIMQYNSSRK 480
  481 MRSADIISMV VDIYGSKELF MTEYRNLMAD RLLAQLDFNS EKEIRNLELL KIRFGESLLH 540
  541 SCEVMLKDVT DSKRINAHIH SDGDRTENQL FDISSLIVSA QFWPSFNKES LQLPEEIENE 600
  601 FKKYTKAYEA YKGNRTLNWR TVTGRVNIEI EIGDRTMEMV VSPILAVIIY HFQTKNEWTI 660
  661 EDLSSITKVP ASALRRRLSF WQNHGLISET TPGIFTLLEK ESEKSQYEDM SLAEADEEDL 720
  721 ESAMASASDQ REEELQVFWS YIVGMLTNLD SMPIDRIHQM LKLFASHSGG VEFTQDELKH 780
  781 FLQRKVREHK LIFSGGVYQL AK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..802] PSI-BLAST 165.0 Crystal Structure of The Cand1-Cul1-Roc1 Complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  7.64524614361803 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  7.50762699341202 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.47735344284087 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  5.22941513446454 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.77201910025409 bayes_pls_golite062009
  • ligase activity
    		•  3.18349288224112 bayes_pls_golite062009
  • transcription factor activity
    		•  2.83460075788873 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.39237599101586 bayes_pls_golite062009
  • transcription activator activity
    		•  2.35901958718112 bayes_pls_golite062009
  • binding
    		•  2.3219000606044 bayes_pls_golite062009
  • protein binding
    		•  2.20237620151495 bayes_pls_golite062009
  • transcription factor binding
    		•  0.63938506997853 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.604021689968387 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.42135864069093 bayes_pls_golite062009
  • DNA binding
    		•  0.418154636457321 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.226414337548244 bayes_pls_golite062009
  • catalytic activity
    		•  0.201606344181603 bayes_pls_golite062009
  • hydrolase activity
    		•  0.140191206949582 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.0565989703351002 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle