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Protein Overview: apt-PB

General Information:
Name(s) found: apt-PB / FBpp0071975 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene apontic is referred to in FlyBase by the symbol Dmel\apt (CG5393, FBgn0015903). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:19452420..19487223. It has the cytological map location 59F1-59F4. There is experimental evidence that it has the molecular function</span>: transcription factor activity; protein binding; sequence-specific DNA binding; transcription activator activity. There is experimental evidence that it is involved in the biological process</span>: central nervous system development; neuromuscular synaptic transmission; positive regulation of transcription from RNA polymerase II promoter; open tracheal system development. 65 alleles are reported. The phenotypes of these alleles are annotated with 20 unique terms, many of which group under: organ system; nervous system; cephalopharyngeal skeleton; peripheral nervous system; embryonic nervous system; adult segment; cuticle; pharyngeal sclerite; adult mesothoracic segment; embryonic/larval dorsal vessel; portion of tissue. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 489 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    Biological Process: negative regulation of oskar mRNA translation [NAS][TAS]
    heart development [TAS]
    central nervous system development [IMP]
    primary branching, open tracheal system [TAS]
    neuromuscular synaptic transmission [IMP]
    positive regulation of transcription from RNA polymerase II promoter [IDA]
    regulation of transcription from RNA polymerase II promoter [NAS]
    open tracheal system development [IMP][TAS]
    Molecular Function: transcription factor activity [IDA]
    protein binding [IPI]
    RNA polymerase II transcription factor activity [NAS]
    mRNA binding [TAS]
    sequence-specific DNA binding [IDA]
    transcription activator activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTMANGAVNK QYSATDLEAF MKIAANWQNS NHNLLEGVDI KTEMTQYMNS PSMNMYKKRE  60
   61 RTQNWNHQEK KYLLDLCRKD MRIIENKRLD AGLTAVKNKA WKIIHQKFSN QFGTDRTCNR 120
  121 LKEQWRRMKA CTRNEILDYN NRLARFGAEV ADRKKPSPFT FEVWDFMQEA KKACKSEALD 180
  181 GIDYSKIPLA LEEGFEYRED YKFNPEDHDM DDSRTPPQEL CDVDIKEEEN NETFNETFNH 240
  241 HHLNQSDILG SGERLSVSPN HSISRNGIHE AESPATISTS NVLDSSGAYM AGGGDMSGFQ 300
  301 ANFNMNNISA TLEALNALRS GQFPSAAAAA AAAIHQHQAQ AQVAMHHQHN NNNNNNNNNE 360
  361 DDEDSMKPQS KRQRTSSGSM LGSEDQAPVL APSVPASSDS QALERSGSSN GLTMPGTAVS 420
  421 TNANSSSSNN NNFELRMFME MQSKEHMMRM KILEVQLQAA KHSRDLVEIN KTLALQKLQL 480
  481 ELASKRLPS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..156] MSA 23.065997 View MSA. No confident structure predictions are available.
    2 View Details [157..285] MSA 1.042986 View MSA. No confident structure predictions are available.
    3 View Details [286..489] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle