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Protein Overview: Klp59C-PA

General Information:
Name(s) found: Klp59C-PA / FBpp0071885 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • The gene Klp59C is referred to in FlyBase by the symbol Dmel\Klp59C (CG3219, FBgn0034824). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:19011517..19013565. It has the cytological map location 59C4. There is experimental evidence that it has the molecular function</span>: motor activity. There is experimental evidence that it is involved in the biological process</span>: mitotic sister chromatid segregation. 6 alleles are reported. The phenotype of these alleles is annotated with: microtubule. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 626 amino acids

    Gene Ontology:
    Cellular Component: kinetochore microtubule [IDA]
    kinesin complex [ISS]
    Biological Process: mitotic sister chromatid segregation [IMP]
    microtubule-based movement [ISS]
    Molecular Function: ATP binding [IEA]
    microtubule motor activity [ISS]
    motor activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKLSIEQKI FIRRSDGRVH LAEIIKLEGG DSKLITVEWP EGHTVRGKEL PLELVVLMNP  60
   61 HIFDSPRCSG GNAASANQTA SISPRSMKQR IATGSLSPVL ATAPPRQQTA PPVREDEVVH 120
  121 QAERMRKERE RRREAQARTR LDREQGKNED PGNPNWEVAR MIRLQREQME SQRVRSGTTN 180
  181 ERINCHQIMV CVRKRPLRRK ELADREQDVV SIPSKHTLVV HEPRKHVNLV KFLENHSFRF 240
  241 DYVFDEECSN ATVYEFTARP LIKHIFDGGM ATCFAYGQTG SGKTYTMGGQ FPGRHQSSMD 300
  301 GIYAMAAKDV FSTLKTVPYN KLNLKVYCSF FEIYGTRVFD LLMPGKPQLR VLEDRNQQVQ 360
  361 VVGLTQNPVQ NTAEVLDLLE LGNSVRTSGH TSANSKSSRS HAVFQIVLRS AAGEKLHGKF 420
  421 SLIDLAGNER GADNSSADRQ TRLEGSEINK SLLVLKECIR ALGRQSSHLP FRGSKLTQVL 480
  481 RDSFIGGKKV KTCMIAMISP CLHSVEHTLN TLRYADRVKE LSVESIPSKR MPDANLGSTS 540
  541 MSDIVCQSST QRLFPCASST SMPGGGNQAQ QHTNTANDLN RSQKPTSKPT YPTSGQQLVQ 600
  601 RKGSSQREAS MMLTKSLAQF RGRNFP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..96] FFAS03 1.02 Solution Structure of the Tudor Domain from Mouse Hypothetical Protein Homologous to Histone Acetyltransferase
    2 View Details [97..531] PSI-BLAST 105.0 No description for 2gryA was found.
    3 View Details [532..626] PSI-BLAST 3.522879 No description for 2dfsA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • chromatin binding
    		•  3.39903944543479 bayes_pls_golite062009
  • binding
    		•  2.96155744225842 bayes_pls_golite062009
  • protein binding
    		•  2.55372006358699 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.73885652606576 bayes_pls_golite062009
  • histone binding
    		•  1.27264385817111 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.11983876800692 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.621667574938228 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.45690927871554 bayes_pls_golite062009
  • DNA binding
    		•  0.411003296485644 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.206602190936326 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.163969786045852 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.153584983966247 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.151023160570585 bayes_pls_golite062009
  • transcription activator activity
    		•  0.102820714122071 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle