YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: FBpp0300559, syn...

General Information:
Name(s) found: FBpp0300559 [FlyBase]
synj-PA / FBpp0071671 [FlyBase]
synj-PB / FBpp0071670 [FlyBase]
Description(s) found:
Found 42 descriptions.
SHOW ALL
  • type=protein; loc=2R:join(17968685..17970142,17970210..17972408); ID=FBpp0300559; name=synj-PC; parent=FBgn0034691,FBtr0308239; dbxref=FlyBase:FBpp0300559,FlyBase_Annotation_IDs:CG6562-PC,REFSEQ:NP_001246454,GB_protein:AFH08207; MD5=80508fbfd3af21adafcb6688a309ae4c; length=1218; release=r5.56; species=Dmel; [FlyBase]
  • The gene synaptojanin is referred to in FlyBase by the symbol Dmel\synj (CG6562, FBgn0034691). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:17967676..17973272. It has the cytological map location 58B4. There is experimental evidence that it has the molecular function</span>: inositol-polyphosphate 5-phosphatase activity. There is experimental evidence that it is involved in the biological process</span>: synaptic vesicle endocytosis; maintenance of presynaptic active zone structure; regulation of synapse structure and activity. 10 alleles are reported. The phenotype of these alleles is annotated with: presynaptic active zone. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene synaptojanin is referred to in FlyBase by the symbol Dmel\synj (CG6562, FBgn0034691). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:17967676..17973272. It has the cytological map location 58B4. There is experimental evidence that it has the molecular function</span>: inositol-polyphosphate 5-phosphatase activity. There is experimental evidence that it is involved in the biological process</span>: synaptic vesicle endocytosis; maintenance of presynaptic active zone structure; regulation of synapse structure and activity. 10 alleles are reported. The phenotype of these alleles is annotated with: presynaptic active zone. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1218 amino acids

    Gene Ontology:
    Cellular Component: terminal button [IDA]
    vesicle membrane [IDA]
    Biological Process: maintenance of presynaptic active zone structure [IMP]
    synaptic vesicle endocytosis [IMP][TAS]
    regulation of synapse structure and activity [IMP]
    dephosphorylation [IEA][NAS]
    neurotransmitter secretion [NAS]
    Molecular Function: inositol trisphosphate phosphatase activity [NAS]
    RNA binding [IEA]
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [IEA]
    inositol-polyphosphate 5-phosphatase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMSKVIRVL EKSIAPSPHS VLLEHRNKSD SILFESHAVA LLTQQETDVI RKQYTKVCDA  60
   61 YGCLGALQLN AGESTVLFLV LVTGCVSMGK IGDIEIFRIT QTTFVSLQNA APNEDKISEV 120
  121 RKLLNSGTFY FAHTNASASA SGASSYRFDI TLCAQRRQQT QETDNRFFWN RMMHIHLMRF 180
  181 GIDCQSWLLQ AMCGSVEVRT VYIGAKQARA AIISRLSCER AGTRFNVRGT NDEGYVANFV 240
  241 ETEQVIYVDG DVTSYVQTRG SVPLFWEQPG VQVGSHKVKL SRGFETSAAA FDRHMSMMRQ 300
  301 RYGYQTVVNL LGSSLVGSKE GEAMLSNEFQ RHHGMSAHKD VPHVVFDYHQ ECRGGNFSAL 360
  361 AKLKERIVAC GANYGVFHAS NGQVLREQFG VVRTNCLDCL DRTNCVQTYL GLDTLGIQLE 420
  421 ALKMGGKQQN ISRFEEIFRQ MWINNGNEVS KIYAGTGAIQ GGSKLMDGAR SAARTIQNNL 480
  481 LDNSKQEAID VLLVGSTLSS ELADRARILL PSNMLHAPTT VLRELCKRYT EYVRPRMARV 540
  541 AVGTYNVNGG KHFRSIVFKD SLADWLLDCH ALARSKALVD VNNPSENVDH PVDIYAIGFE 600
  601 EIVDLNASNI MAASTDNAKL WAEELQKTIS RDNDYVLLTY QQLVGVCLYI YIRPEHAPHI 660
  661 RDVAIDCVKT GLGGATGNKG ACAIRFVLHG TSMCFVCAHF AAGQSQVAER NADYAEITRK 720
  721 LAFPMGRTLK SHDWVFWCGD FNYRIDMEKD ELKECVRNGD LSTVLEFDQL RKEQEAGNVF 780
  781 GEFLEGEITF DPTYKYDLFS DDYDTSEKQR APAWTDRVLW RRRKALAEGD FAASAWNPGK 840
  841 LIHYGRSELK QSDHRPVIAI IDAEIMEIDQ QRRRAVFEQV IRDLGPPDST IVVHVLESSA 900
  901 TGDEDGPTIY DENVMSALIT ELSKMGEVTL VRYVEDTMWV TFRDGESALN ASSKKSIQVC 960
  961 GLDLILELKS KDWQHLVDSE IELCTTNTIP LCANPVEHAQ LLQAITPELP QRPKQPPTRP1020
 1021 PARPPMPMSP KNSPRHLPHV GVISIVPKPA KPPMPPQPQS QPLIPSPLQP QVAPPRPPAM1080
 1081 DTTPSSKSQS PTELVSASSS TSSSGKTSPT APAVLSGPPT PPRQMQSKQA TPVSTPTRQV1140
 1141 GSPKDPIPSD TAYETASNIY EEIQEDVPAP RHPPPAGPPP VIGAPMGPPP PLPNRRGPPP1200
 1201 IPNRSGNAPP LPTRPANN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..180] MSA 2.181973 View MSA. No confident structure predictions are available.
    2 View Details [181..339] MSA 1.193949 View MSA. No confident structure predictions are available.
    3 View Details [340..497] deduced N/A No confident structure predictions are available.
    4 View Details [498..886] PSI-BLAST 87.045757 Synaptojanin, IPP5C domain
    5 View Details [887..950] FFAS03 2.86 Solution structure of RNP domain in Synaptojanin 2
    6 View Details [951..1218] PSI-BLAST 7.69897 No description for 1y0fA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • hydrolase activity, acting on ester bonds
    		•  5.89224335840239 bayes_pls_golite062009
  • phosphatidylinositol bisphosphate phosphatase activity
    		•  5.76202422677892 bayes_pls_golite062009
  • phosphoinositide 5-phosphatase activity
    		•  5.57319461575586 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
    		•  5.57319461575586 bayes_pls_golite062009
  • phosphatase activity
    		•  5.52443562029354 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  5.46652892688189 bayes_pls_golite062009
  • inositol trisphosphate phosphatase activity
    		•  4.92394158055025 bayes_pls_golite062009
  • inositol-polyphosphate 5-phosphatase activity
    		•  4.20215185632047 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  3.88924621938812 bayes_pls_golite062009
  • lipid phosphatase activity
    		•  3.07322777760243 bayes_pls_golite062009
  • phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
    		•  2.64934277728302 bayes_pls_golite062009
  • phosphatidylinositol-4-phosphate phosphatase activity
    		•  2.64934277728302 bayes_pls_golite062009
  • hydrolase activity
    		•  2.1345957248514 bayes_pls_golite062009
  • phosphatidylinositol-3-phosphatase activity
    		•  1.98439062808392 bayes_pls_golite062009
  • catalytic activity
    		•  1.76511376991978 bayes_pls_golite062009
  • protein binding
    		•  1.5271034827438 bayes_pls_golite062009
  • DNA binding
    		•  1.45924870577723 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.38966944580562 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.37597495586534 bayes_pls_golite062009
  • binding
    		•  1.31660174492743 bayes_pls_golite062009
  • nuclease activity
    		•  0.782488606133604 bayes_pls_golite062009
  • phosphatidylinositol trisphosphate phosphatase activity
    		•  0.731013770154616 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  0.620825895803427 bayes_pls_golite062009
  • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
    		•  0.558149994726796 bayes_pls_golite062009
  • transcription activator activity
    		•  0.239217168608234 bayes_pls_golite062009
  • exonuclease activity
    		•  0.219613338022829 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.213742479001316 bayes_pls_golite062009
  • transcription factor binding
    		•  0.19603200433138 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  0.137101173922861 bayes_pls_golite062009
    5
    Term Confidence Notes
  • nucleic acid binding
    		•  3.6649737847299 bayes_pls_golite062009
  • binding
    		•  3.05100551329453 bayes_pls_golite062009
  • protein phosphatase 2B binding
    		•  2.57573204792118 bayes_pls_golite062009
  • mRNA binding
    		•  2.34625118663896 bayes_pls_golite062009
  • protein binding
    		•  2.10850948869511 bayes_pls_golite062009
  • RNA binding
    		•  2.00450757962078 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.80774225072473 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.20182415212933 bayes_pls_golite062009
  • transporter activity
    		•  1.17508255371693 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.076425286008 bayes_pls_golite062009
  • DNA binding
    		•  1.06738888024145 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.805461754846875 bayes_pls_golite062009
  • structural molecule activity
    		•  0.767649718525223 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.54965830425226 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.298769812594949 bayes_pls_golite062009
  • transcription factor activity
    		•  0.273768131383019 bayes_pls_golite062009
  • translation regulator activity
    		•  0.246220338604608 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.23733335659183 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0463102914393024 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.0127733116412899 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0110854752198585 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.00299446537936399 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle