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View Structure Prediction Details

Protein: FBpp0300559, syn...
Organism: Drosophila melanogaster
Length: 1218 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0300559, syn....

Description E-value Query
Range
Subject
Range
gi|63237149, gi|... - gi|63237149|gb|AAB60525.2| 145 kDa synaptojanin isoform [Rattus norvegicus], gi|209870039|ref|NP_445...
1070.0 [0..1] [1217..1]

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Predicted Domain #1
Region A:
Residues: [1-180]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMSKVIRVL EKSIAPSPHS VLLEHRNKSD SILFESHAVA LLTQQETDVI RKQYTKVCDA  60
   61 YGCLGALQLN AGESTVLFLV LVTGCVSMGK IGDIEIFRIT QTTFVSLQNA APNEDKISEV 120
  121 RKLLNSGTFY FAHTNASASA SGASSYRFDI TLCAQRRQQT QETDNRFFWN RMMHIHLMRF 180
  181 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [181-339]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIDCQSWLLQ AMCGSVEVRT VYIGAKQARA AIISRLSCER AGTRFNVRGT NDEGYVANFV  60
   61 ETEQVIYVDG DVTSYVQTRG SVPLFWEQPG VQVGSHKVKL SRGFETSAAA FDRHMSMMRQ 120
  121 RYGYQTVVNL LGSSLVGSKE GEAMLSNEFQ RHHGMSAHK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [340-497]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVPHVVFDYH QECRGGNFSA LAKLKERIVA CGANYGVFHA SNGQVLREQF GVVRTNCLDC  60
   61 LDRTNCVQTY LGLDTLGIQL EALKMGGKQQ NISRFEEIFR QMWINNGNEV SKIYAGTGAI 120
  121 QGGSKLMDGA RSAARTIQNN LLDNSKQEAI DVLLVGST

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [498-886]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSSELADRAR ILLPSNMLHA PTTVLRELCK RYTEYVRPRM ARVAVGTYNV NGGKHFRSIV  60
   61 FKDSLADWLL DCHALARSKA LVDVNNPSEN VDHPVDIYAI GFEEIVDLNA SNIMAASTDN 120
  121 AKLWAEELQK TISRDNDYVL LTYQQLVGVC LYIYIRPEHA PHIRDVAIDC VKTGLGGATG 180
  181 NKGACAIRFV LHGTSMCFVC AHFAAGQSQV AERNADYAEI TRKLAFPMGR TLKSHDWVFW 240
  241 CGDFNYRIDM EKDELKECVR NGDLSTVLEF DQLRKEQEAG NVFGEFLEGE ITFDPTYKYD 300
  301 LFSDDYDTSE KQRAPAWTDR VLWRRRKALA EGDFAASAWN PGKLIHYGRS ELKQSDHRPV 360
  361 IAIIDAEIME IDQQRRRAVF EQVIRDLGP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.045757
Match: 1i9yA
Description: Synaptojanin, IPP5C domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity, acting on ester bonds 5.89224335840239 bayes_pls_golite062009
phosphatidylinositol bisphosphate phosphatase activity 5.76202422677892 bayes_pls_golite062009
phosphoinositide 5-phosphatase activity 5.57319461575586 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 5.57319461575586 bayes_pls_golite062009
phosphatase activity 5.52443562029354 bayes_pls_golite062009
phosphoric ester hydrolase activity 5.46652892688189 bayes_pls_golite062009
inositol trisphosphate phosphatase activity 4.92394158055025 bayes_pls_golite062009
inositol-polyphosphate 5-phosphatase activity 4.20215185632047 bayes_pls_golite062009
inositol or phosphatidylinositol phosphatase activity 3.88924621938812 bayes_pls_golite062009
lipid phosphatase activity 3.07322777760243 bayes_pls_golite062009
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity 2.64934277728302 bayes_pls_golite062009
phosphatidylinositol-4-phosphate phosphatase activity 2.64934277728302 bayes_pls_golite062009
hydrolase activity 2.1345957248514 bayes_pls_golite062009
phosphatidylinositol-3-phosphatase activity 1.98439062808392 bayes_pls_golite062009
catalytic activity 1.76511376991978 bayes_pls_golite062009
protein binding 1.5271034827438 bayes_pls_golite062009
DNA binding 1.45924870577723 bayes_pls_golite062009
nucleic acid binding 1.38966944580562 bayes_pls_golite062009
transcription regulator activity 1.37597495586534 bayes_pls_golite062009
binding 1.31660174492743 bayes_pls_golite062009
nuclease activity 0.782488606133604 bayes_pls_golite062009
phosphatidylinositol trisphosphate phosphatase activity 0.731013770154616 bayes_pls_golite062009
deoxyribonuclease activity 0.620825895803427 bayes_pls_golite062009
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity 0.558149994726796 bayes_pls_golite062009
transcription activator activity 0.239217168608234 bayes_pls_golite062009
exonuclease activity 0.219613338022829 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.213742479001316 bayes_pls_golite062009
transcription factor binding 0.19603200433138 bayes_pls_golite062009
phosphoric diester hydrolase activity 0.137101173922861 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [887-950]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDSTIVVHVL ESSATGDEDG PTIYDENVMS ALITELSKMG EVTLVRYVED TMWVTFRDGE  60
   61 SALN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.86
Match: 1ufwA
Description: Solution structure of RNP domain in Synaptojanin 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 3.6649737847299 bayes_pls_golite062009
binding 3.05100551329453 bayes_pls_golite062009
protein phosphatase 2B binding 2.57573204792118 bayes_pls_golite062009
mRNA binding 2.34625118663896 bayes_pls_golite062009
protein binding 2.10850948869511 bayes_pls_golite062009
RNA binding 2.00450757962078 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.80774225072473 bayes_pls_golite062009
transcription regulator activity 1.20182415212933 bayes_pls_golite062009
transporter activity 1.17508255371693 bayes_pls_golite062009
transmembrane transporter activity 1.076425286008 bayes_pls_golite062009
DNA binding 1.06738888024145 bayes_pls_golite062009
substrate-specific transporter activity 0.805461754846875 bayes_pls_golite062009
structural molecule activity 0.767649718525223 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.54965830425226 bayes_pls_golite062009
cytoskeletal protein binding 0.298769812594949 bayes_pls_golite062009
transcription factor activity 0.273768131383019 bayes_pls_golite062009
translation regulator activity 0.246220338604608 bayes_pls_golite062009
mRNA 3'-UTR binding 0.23733335659183 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0463102914393024 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.0127733116412899 bayes_pls_golite062009
pyrophosphatase activity 0.0110854752198585 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.00299446537936399 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [951-1218]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASSKKSIQVC GLDLILELKS KDWQHLVDSE IELCTTNTIP LCANPVEHAQ LLQAITPELP  60
   61 QRPKQPPTRP PARPPMPMSP KNSPRHLPHV GVISIVPKPA KPPMPPQPQS QPLIPSPLQP 120
  121 QVAPPRPPAM DTTPSSKSQS PTELVSASSS TSSSGKTSPT APAVLSGPPT PPRQMQSKQA 180
  181 TPVSTPTRQV GSPKDPIPSD TAYETASNIY EEIQEDVPAP RHPPPAGPPP VIGAPMGPPP 240
  241 PLPNRRGPPP IPNRSGNAPP LPTRPANN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.69897
Match: 1y0fA
Description: No description for 1y0fA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle