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Protein Overview: shg-PA

General Information:
Name(s) found: shg-PA / FBpp0071475 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene shotgun is referred to in FlyBase by the symbol Dmel\shg (CG3722, FBgn0003391). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:16938107..16944664. It has the cytological map location 57B15-57B16. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 25 unique biological process</span> terms, many of which group under: anatomical structure development; organ morphogenesis; organ development; reproductive process in a multicellular organism; open tracheal system development; cell adhesion; cell projection organization; cell-cell adhesion; sensory organ development; apical protein localization; homophilic cell adhesion; gonadal mesoderm development; cell division; ommatidial rotation; gland morphogenesis; cell junction organization. 70 alleles are reported. The phenotypes of these alleles are annotated with 48 unique terms, many of which group under: organ system; nervous system; embryonic nervous system; primordium; female germline cyst; portion of tissue; peripheral nervous system; embryonic glial cell; multi-cell-component structure; adult segment; late extended germ band embryo. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1507 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    adherens junction [NAS]
    spot adherens junction [IDA][NAS]
    cell-cell adherens junction [TAS]
    zonula adherens [NAS]
    apical junction complex [IDA]
    integral to membrane [NAS]
    filopodium [IDA]
    plasma membrane [IDA][NAS]
    Biological Process: ovarian follicle cell migration [TAS]
    cell projection assembly [IMP]
    gonad morphogenesis [IGI][IMP]
    nervous system development [IMP]
    germarium-derived female germ-line cyst encapsulation [TAS]
    axon guidance [NAS]
    germ-line stem cell division [TAS]
    border follicle cell migration [IMP][TAS]
    homophilic cell adhesion [IDA][ISS][NAS]
    maintenance of epithelial integrity, open tracheal system [IMP]
    oocyte anterior/posterior axis specification [NAS]
    salivary gland morphogenesis [IGI]
    gonadal mesoderm development [IMP]
    heart development [IMP][TAS]
    somatic stem cell division [TAS]
    compound eye morphogenesis [IGI][IMP]
    axonogenesis [IMP]
    apical protein localization [IMP]
    optic lobe placode development [IMP]
    somatic stem cell maintenance [TAS]
    oocyte localization during germarium-derived egg chamber formation [TAS]
    cell-cell adhesion [IMP]
    calcium-dependent cell-cell adhesion [ISS][NAS]
    pole cell migration [TAS]
    ommatidial rotation [IMP]
    cell morphogenesis [IMP]
    establishment or maintenance of cell polarity [NAS]
    head involution [IMP]
    asymmetric cell division [IMP]
    brain development [IMP]
    open tracheal system development [IMP][TAS]
    gonad development [TAS]
    morphogenesis of an epithelium [NAS][TAS]
    oogenesis [IMP][TAS]
    zonula adherens assembly [IMP]
    morphogenesis of a polarized epithelium [IMP]
    branch fusion, open tracheal system [IMP][TAS]
    gastrulation involving germ band extension [IMP]
    Molecular Function: protein binding [IPI]
    calcium ion binding [IEA]
    cell adhesion molecule binding [ISS]
    beta-catenin binding [NAS]
    receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTSVQRMSR SYHCINMSAT PQAGHLNPAQ QQTHQQHKRK CRDLGRRLIP ARLLLGVIVA  60
   61 ISLLSPALAL HSPPDKNFSG DNRKPAFKNC AGYAPKVKEE QPENTYVLTV EAVDPDPDQV 120
  121 IRYSIVQSPF ERPKFFINPS TGVIFTTHTF DRDEPIHEKF VFVTVQATDN GLPPLDDVCT 180
  181 FNVTIEDIND NAPAFNKARY DESMSENAQP DAVVMTISAS DFDDGNNSLV EYEILRERDF 240
  241 QYFKIDKESG IIYLKRPIDK RPGQSYAIIV RAYNVVPDPP QDAQIEVRIR VVESSIKPPS 300
  301 FVNPIDTPIY LKENLKNFTH PIATLRAVSN MPDKPEVIFE LNTGRTEQTN SKNTFVFNQI 360
  361 GNEVTISLGK TLDYEAITDY TLTMIVRNTH ELGTEHQIKI QVEDVNDNIP YYTEVKSGTI 420
  421 LENEPPGTPV MQVRAFDMDG TSANNIVSFE LADNREYFTI DPNTGNITAL TTFDREERDF 480
  481 YNVKVIASDN SPSSLFDNGE PNRGHQVFRI SIGDKNDHKP HFQQDKYLAE RLLEDANTNT 540
  541 EVIEVKAEDE DNASQILYSI ESGNVGDAFK IGLKTGKITV NQKLDYETIT EYELKVRAFD 600
  601 GIYDDYTTVV IKIEDVNDNP PVFKQDYSVT ILEETTYDDC ILTVEAYDPD IKDRNADQHI 660
  661 VYSIHQNDGN RWTIDNSGCL RLVKTLDRDP PNGHKNWQVL IKANDEDGVG TTVSTVKEVT 720
  721 VTLKDINDNA PFLINEMPVY WQENRNPGHV VQLQANDYDD TPGAGNFTFG IDSEATPDIK 780
  781 TKFSMDGDYL HANVQFDREA QKEYFIPIRI SDSGVPRQSA VSILHLVIGD VNDNAMSEGS 840
  841 SRIFIYNYKG EAPETDIGRV FVDDLDDWDL EDKYFEWKDL PHDQFRLNPS TGMITMLVHT 900
  901 AEGEYDLSFV VTEDSMFVPR HSVDAYVTVV VRELPEEAVD KSGSIRFINV TKEEFISVPR 960
  961 DFQSPDALSL KDRLQLSLAK LFNTSVSNVD VFTVLQNENH TLDVRFSAHG SPYYAPEKLN1020
 1021 GIVAQNQQRL ENELDLQMLM VNIDECLIEK FKCEESCTNE LHKSSVPYMI YSNTTSFVGV1080
 1081 NAFVQAQCVC EAPLMRRCLN GGSPRYGEND VCDCIDGFTG PHCELVSVAF YGSGYAFYEP1140
 1141 IAACNNTKIS LEITPQIDQG LIMYLGPLNF NPLLAISDFL ALELDNGYPV LTVDYGSGAI1200
 1201 RIRHQHIKMV ADRTYQLDII LQRTSIEMTV DNCRLSTCQT LGAPIGPNEF LNVNAPLQLG1260
 1261 GTPVDLEQLG RQLNWTHVPN QKGFFGCIRN LTINEQTYNL GMPSVFRNID SGCQQSVAVA1320
 1321 FSFGIDRNFI IAIIVCLALL LIILLAVVVQ KKQKNGWHEK DIDDIRETII NYEDEGGGER1380
 1381 DTDYDLNVLR TQPFYEEKLY KDPHALQGNM RDPNDIPDIA DFLGDKKENC DRDVGATTVD1440
 1441 DVRHYAYEGD GNSDGSLSSL ASCTDDGDLN FDYLSNFGPR FRKLADMYGE EPSDTDSNVD1500
 1501 DDQGWRI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..82] deduced N/A No confident structure predictions are available.
    2 View Details [83..174] PSI-BLAST 71.154902 C-cadherin ectodomain
    3 View Details [175..833] PSI-BLAST 86.0 W-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography
    4 View Details [834..1008] FFAS03 4.23 N-cadherin (neural)
    5 View Details [1009..1119] PSI-BLAST 5.0 NMR structure of the human NOTCH-1 ligand binding region
    6 View Details [1120..1374] PSI-BLAST 24.221849 Laminin alpha2 chain
    7 View Details [1375..1507] PSI-BLAST 38.154902 Phosphorylated E-cadherin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • adiponectin binding
    		•  5.45401355603234 bayes_pls_golite062009
  • RPTP-like protein binding
    		•  4.49814816743203 bayes_pls_golite062009
  • beta-catenin binding
    		•  3.68953518862418 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  3.53124748663376 bayes_pls_golite062009
  • receptor activity
    		•  2.60335849566679 bayes_pls_golite062009
  • protein binding
    		•  2.38439953342984 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.14462434886014 bayes_pls_golite062009
  • binding
    		•  1.95002373838391 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.89064998704554 bayes_pls_golite062009
  • signal transducer activity
    		•  1.89064998704554 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.79832011407406 bayes_pls_golite062009
  • oligopeptide transporter activity
    		•  1.65061971409738 bayes_pls_golite062009
  • protein phosphatase binding
    		•  1.48586031254036 bayes_pls_golite062009
  • phosphatase binding
    		•  1.3203536113366 bayes_pls_golite062009
  • transporter activity
    		•  1.25879641888861 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.23055638745499 bayes_pls_golite062009
  • receptor binding
    		•  1.08714216501578 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.05009355310184 bayes_pls_golite062009
  • secondary active oligopeptide transmembrane transporter activity
    		•  0.958774971306261 bayes_pls_golite062009
  • proton-dependent oligopeptide secondary active transmembrane transporter activity
    		•  0.958774971306261 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.803724175009217 bayes_pls_golite062009
  • transcription activator activity
    		•  0.459677353469892 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.267452145889378 bayes_pls_golite062009
  • peptide transporter activity
    		•  0.0941400589560409 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • adiponectin binding
    		•  5.08348001712357 bayes_pls_golite062009
  • RPTP-like protein binding
    		•  4.01441665644643 bayes_pls_golite062009
  • beta-catenin binding
    		•  3.43048969470301 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  3.19367562970896 bayes_pls_golite062009
  • receptor activity
    		•  2.5256294718594 bayes_pls_golite062009
  • protein binding
    		•  2.29912143474826 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.10923172564176 bayes_pls_golite062009
  • binding
    		•  1.89176357327828 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.86767346187817 bayes_pls_golite062009
  • signal transducer activity
    		•  1.86767346187817 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.69585074100447 bayes_pls_golite062009
  • oligopeptide transporter activity
    		•  1.52695626830213 bayes_pls_golite062009
  • transporter activity
    		•  1.2712931562513 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.24409711891756 bayes_pls_golite062009
  • protein phosphatase binding
    		•  1.18659775077962 bayes_pls_golite062009
  • receptor binding
    		•  1.07643977987241 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.06119404242236 bayes_pls_golite062009
  • phosphatase binding
    		•  1.03491617752741 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.812088897897613 bayes_pls_golite062009
  • secondary active oligopeptide transmembrane transporter activity
    		•  0.528528464646393 bayes_pls_golite062009
  • proton-dependent oligopeptide secondary active transmembrane transporter activity
    		•  0.528528464646393 bayes_pls_golite062009
  • transcription activator activity
    		•  0.449616684547857 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.274124060229983 bayes_pls_golite062009
  • peptide transporter activity
    		•  0.00772839924958607 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle