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View Structure Prediction Details

Protein: shg-PA
Organism: Drosophila melanogaster
Length: 1507 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for shg-PA.

Description E-value Query
Range		 Subject
Range
gi|517102 - gi|517102|dbj|BAA05942.1| DE-cadherin [Drosophila melanogaster]
 1215.0 [0..1] [1507..1]

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Predicted Domain #1
Region A:
Residues: [1-82] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTSVQRMSR SYHCINMSAT PQAGHLNPAQ QQTHQQHKRK CRDLGRRLIP ARLLLGVIVA  60
   61 ISLLSPALAL HSPPDKNFSG DN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [83-174] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKPAFKNCAG YAPKVKEEQP ENTYVLTVEA VDPDPDQVIR YSIVQSPFER PKFFINPSTG  60
   61 VIFTTHTFDR DEPIHEKFVF VTVQATDNGL PP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.154902
Match: 1l3wA
Description: C-cadherin ectodomain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
adiponectin binding 5.45401355603234 bayes_pls_golite062009
RPTP-like protein binding 4.49814816743203 bayes_pls_golite062009
beta-catenin binding 3.68953518862418 bayes_pls_golite062009
cell adhesion molecule binding 3.53124748663376 bayes_pls_golite062009
receptor activity 2.60335849566679 bayes_pls_golite062009
protein binding 2.38439953342984 bayes_pls_golite062009
transmembrane receptor activity 2.14462434886014 bayes_pls_golite062009
binding 1.95002373838391 bayes_pls_golite062009
molecular transducer activity 1.89064998704554 bayes_pls_golite062009
signal transducer activity 1.89064998704554 bayes_pls_golite062009
G-protein coupled receptor activity 1.79832011407406 bayes_pls_golite062009
oligopeptide transporter activity 1.65061971409738 bayes_pls_golite062009
protein phosphatase binding 1.48586031254036 bayes_pls_golite062009
phosphatase binding 1.3203536113366 bayes_pls_golite062009
transporter activity 1.25879641888861 bayes_pls_golite062009
transcription regulator activity 1.23055638745499 bayes_pls_golite062009
receptor binding 1.08714216501578 bayes_pls_golite062009
transmembrane transporter activity 1.05009355310184 bayes_pls_golite062009
secondary active oligopeptide transmembrane transporter activity 0.958774971306261 bayes_pls_golite062009
proton-dependent oligopeptide secondary active transmembrane transporter activity 0.958774971306261 bayes_pls_golite062009
substrate-specific transporter activity 0.803724175009217 bayes_pls_golite062009
transcription activator activity 0.459677353469892 bayes_pls_golite062009
active transmembrane transporter activity 0.267452145889378 bayes_pls_golite062009
peptide transporter activity 0.0941400589560409 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [175-833] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDDVCTFNVT IEDINDNAPA FNKARYDESM SENAQPDAVV MTISASDFDD GNNSLVEYEI  60
   61 LRERDFQYFK IDKESGIIYL KRPIDKRPGQ SYAIIVRAYN VVPDPPQDAQ IEVRIRVVES 120
  121 SIKPPSFVNP IDTPIYLKEN LKNFTHPIAT LRAVSNMPDK PEVIFELNTG RTEQTNSKNT 180
  181 FVFNQIGNEV TISLGKTLDY EAITDYTLTM IVRNTHELGT EHQIKIQVED VNDNIPYYTE 240
  241 VKSGTILENE PPGTPVMQVR AFDMDGTSAN NIVSFELADN REYFTIDPNT GNITALTTFD 300
  301 REERDFYNVK VIASDNSPSS LFDNGEPNRG HQVFRISIGD KNDHKPHFQQ DKYLAERLLE 360
  361 DANTNTEVIE VKAEDEDNAS QILYSIESGN VGDAFKIGLK TGKITVNQKL DYETITEYEL 420
  421 KVRAFDGIYD DYTTVVIKIE DVNDNPPVFK QDYSVTILEE TTYDDCILTV EAYDPDIKDR 480
  481 NADQHIVYSI HQNDGNRWTI DNSGCLRLVK TLDRDPPNGH KNWQVLIKAN DEDGVGTTVS 540
  541 TVKEVTVTLK DINDNAPFLI NEMPVYWQEN RNPGHVVQLQ ANDYDDTPGA GNFTFGIDSE 600
  601 ATPDIKTKFS MDGDYLHANV QFDREAQKEY FIPIRISDSG VPRQSAVSIL HLVIGDVND

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 86.0
Match: 1q55A
Description: W-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [834-1008] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAMSEGSSRI FIYNYKGEAP ETDIGRVFVD DLDDWDLEDK YFEWKDLPHD QFRLNPSTGM  60
   61 ITMLVHTAEG EYDLSFVVTE DSMFVPRHSV DAYVTVVVRE LPEEAVDKSG SIRFINVTKE 120
  121 EFISVPRDFQ SPDALSLKDR LQLSLAKLFN TSVSNVDVFT VLQNENHTLD VRFSA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.23
Match: 1ncjA
Description: N-cadherin (neural)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
adiponectin binding 5.08348001712357 bayes_pls_golite062009
RPTP-like protein binding 4.01441665644643 bayes_pls_golite062009
beta-catenin binding 3.43048969470301 bayes_pls_golite062009
cell adhesion molecule binding 3.19367562970896 bayes_pls_golite062009
receptor activity 2.5256294718594 bayes_pls_golite062009
protein binding 2.29912143474826 bayes_pls_golite062009
transmembrane receptor activity 2.10923172564176 bayes_pls_golite062009
binding 1.89176357327828 bayes_pls_golite062009
molecular transducer activity 1.86767346187817 bayes_pls_golite062009
signal transducer activity 1.86767346187817 bayes_pls_golite062009
G-protein coupled receptor activity 1.69585074100447 bayes_pls_golite062009
oligopeptide transporter activity 1.52695626830213 bayes_pls_golite062009
transporter activity 1.2712931562513 bayes_pls_golite062009
transcription regulator activity 1.24409711891756 bayes_pls_golite062009
protein phosphatase binding 1.18659775077962 bayes_pls_golite062009
receptor binding 1.07643977987241 bayes_pls_golite062009
transmembrane transporter activity 1.06119404242236 bayes_pls_golite062009
phosphatase binding 1.03491617752741 bayes_pls_golite062009
substrate-specific transporter activity 0.812088897897613 bayes_pls_golite062009
secondary active oligopeptide transmembrane transporter activity 0.528528464646393 bayes_pls_golite062009
proton-dependent oligopeptide secondary active transmembrane transporter activity 0.528528464646393 bayes_pls_golite062009
transcription activator activity 0.449616684547857 bayes_pls_golite062009
active transmembrane transporter activity 0.274124060229983 bayes_pls_golite062009
peptide transporter activity 0.00772839924958607 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [1009-1119] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HGSPYYAPEK LNGIVAQNQQ RLENELDLQM LMVNIDECLI EKFKCEESCT NELHKSSVPY  60
   61 MIYSNTTSFV GVNAFVQAQC VCEAPLMRRC LNGGSPRYGE NDVCDCIDGF T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1tozA
Description: NMR structure of the human NOTCH-1 ligand binding region
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1120-1374] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPHCELVSVA FYGSGYAFYE PIAACNNTKI SLEITPQIDQ GLIMYLGPLN FNPLLAISDF  60
   61 LALELDNGYP VLTVDYGSGA IRIRHQHIKM VADRTYQLDI ILQRTSIEMT VDNCRLSTCQ 120
  121 TLGAPIGPNE FLNVNAPLQL GGTPVDLEQL GRQLNWTHVP NQKGFFGCIR NLTINEQTYN 180
  181 LGMPSVFRNI DSGCQQSVAV AFSFGIDRNF IIAIIVCLAL LLIILLAVVV QKKQKNGWHE 240
  241 KDIDDIRETI INYED

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.221849
Match: 1dykA
Description: Laminin alpha2 chain
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1375-1507] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGGGERDTDY DLNVLRTQPF YEEKLYKDPH ALQGNMRDPN DIPDIADFLG DKKENCDRDV  60
   61 GATTVDDVRH YAYEGDGNSD GSLSSLASCT DDGDLNFDYL SNFGPRFRKL ADMYGEEPSD 120
  121 TDSNVDDDQG WRI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.154902
Match: 1i7wB
Description: Phosphorylated E-cadherin
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle