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Protein Overview: 18w-PA

General Information:
Name(s) found: 18w-PA / FBpp0085620 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene 18 wheeler is referred to in FlyBase by the symbol Dmel\18w (CG8896, FBgn0004364). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15999016..16004437. It has the cytological map location 56F8. Based on sequence similarity, it is predicted to have molecular function</span>: transmembrane receptor activity. There is experimental evidence that it is involved in the biological process</span>: immune response; cell adhesion; anatomical structure morphogenesis; antibacterial humoral response. 18 alleles are reported. The phenotypes of these alleles are annotated with: leg; antenna; haltere; wing. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1385 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDA]
    cytoplasm [IDA]
    integral to membrane [ISS]
    plasma membrane [IDA][ISS]
    intrinsic to membrane [IEA]
    Biological Process: immune response [IEP]
    embryonic morphogenesis [TAS]
    signal transduction [IEA][ISS]
    multicellular organismal development [TAS]
    innate immune response [IEA]
    anatomical structure morphogenesis [IMP]
    cell adhesion [IDA]
    antibacterial humoral response [IMP][NAS][TAS]
    [NOT]antimicrobial humoral response [IMP]
    defense response [TAS]
    Molecular Function: transmembrane receptor activity [ISS]
    protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPATSSIITI IAVAACLLLL VADAHAQQQC NWQYGLTTMD IRCSVRALES GTGTPLDLQV  60
   61 AEAAGRLDLQ CSQELLHASE LAPGLFRQLQ KLSELRIDAC KLQRVPPNAF EGLMSLKRLT 120
  121 LESHNAVWGP GKTLELHGQS FQGLKELSEL HLGDNNIRQL PEGVWCSMPS LQLLNLTQNR 180
  181 IRSAEFLGFS EKLCAGSALS NANGAVSGGS ELQTLDVSFN ELRSLPDAWG ASRLRRLQTL 240
  241 SLQHNNISTL APNALAGLSS LRVLNISYNH LVSLPSEAFA GNKELRELHL QGNDLYELPK 300
  301 GLLHRLEQLL VLDLSGNQLT SHHVDNSTFA GLIRLIVLNL SNNALTRIGS KTFKELYFLQ 360
  361 ILDMRNNSIG HIEEGAFLPL YNLHTLNLAE NRLHTLDNRI FNGLYVLTKL TLNNNLVSIV 420
  421 ESQAFRNCSD LKELDLSSNQ LTEVPEAVQD LSMLKTLDLG ENQISEFKNN TFRNLNQLTG 480
  481 LRLIDNRIGN ITVGMFQDLP RLSVLNLAKN RIQSIERGAF DKNTEIEAIR LDKNFLTDIN 540
  541 GIFATLASLL WLNLSENHLV WFDYAFIPSN LKWLDIHGNY IEALGNYYKL QEEIRVTTLD 600
  601 ASHNRITEIG AMSVPNSIEL LFINNNIIGQ IQANTFVDKT RLARVDLYAN VLSKISLNAL 660
  661 RVAPVSAEKP VPEFYLGGNP FECDCSMEWL QRINNLTTRQ HPHVVDLGNI ECLMPHSRSA 720
  721 PLRPLASLSA SDFVCKYESH CPPTCHCCEY EQCECEVICP GNCSCFHDAT WATNIVDCGR 780
  781 QDLAALPNRI PQDVSDLYLD GNNMPELEVG HLTGRRNLRA LYLNASNLMT LQNGSLAQLV 840
  841 NLRVLHLENN KLTALEGTEF RSLGLLRELY LHNNMLTHIS NATFEPLVSL EVLRLDNNRL 900
  901 SSLPHLQYRH SLQGLTLGRN AWSCRCQQLR ELAQFVSDNA MVVRDAHDIY CLDAGIKREL 960
  961 ELIGNLANGP DCSDLLDASA SNISSSQDLA GGYRLPLLAA VLVLIFLVVV LIIVFVFRES1020
 1021 VRMWLFAHYG VRVCEPRFED AGKLYDAIIL HSEKDYEFVC RNIAAELEHG RPPFRLCIQQ1080
 1081 RDLPPQASHL QLVEGARASR KIILVLTRNL LATEWNRIEF RNAFHESLRG LAQKLVIIEE1140
 1141 TSVSAEAEDV AELSPYLKSV PSNRLLTCDR YFWEKLRYAI PIELSPRGNN YTLDHHERFK1200
 1201 QPVSPGMIFR QAPPPPAYYC TEEMEANYSS ATTATPSPRP TRPGGAARIV DSMPMPMRPP1260
 1261 SEHIYHSIES EYSAYDQHEA LSMIPTGLMH QHQQQQLRLH QQQQQQQQQR LLQPQFRAMP1320
 1321 QQAIPAPSAP VHLRSGSGLS QASTSTQSTA QASTSAAAAQ QQQQQQQQQA AGSEAANKNG1380
 1381 QAFLV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..358] PSI-BLAST 42.045757 No description for 2z82A was found.
    2 View Details [359..1031] PSI-BLAST 61.09691 The molecular structure of toll-like receptor 3 ligand binding domain
    3 View Details [1032..1194] PSI-BLAST 49.154902 Toll-like receptor 2, TLR2
    4 View Details [1195..1385] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • receptor activity
    		•  4.09933951703109 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.9640091493609 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.16173995936925 bayes_pls_golite062009
  • signal transducer activity
    		•  3.16173995936925 bayes_pls_golite062009
  • binding
    		•  2.52555346445919 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.35125182904603 bayes_pls_golite062009
  • protein binding
    		•  2.10005190551596 bayes_pls_golite062009
  • lipopolysaccharide binding
    		•  2.0324670463023 bayes_pls_golite062009
  • siRNA binding
    		•  1.9040679863659 bayes_pls_golite062009
  • growth factor activity
    		•  1.78996364452304 bayes_pls_golite062009
  • receptor binding
    		•  1.72672102029619 bayes_pls_golite062009
    		• 1.60235760704566 bayes_pls_golite062009
  • RNA binding
    		•  1.4672851259337 bayes_pls_golite062009
  • peptidoglycan binding
    		•  1.415118707351 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.36750739353858 bayes_pls_golite062009
  • pattern binding
    		•  1.18233476165206 bayes_pls_golite062009
  • DNA binding
    		•  1.14457763159383 bayes_pls_golite062009
    		• 0.741742562203891 bayes_pls_golite062009
  • double-stranded RNA binding
    		•  0.127722958598936 bayes_pls_golite062009
  • growth factor binding
    		•  0.0973189460931883 bayes_pls_golite062009
  • interleukin-1 receptor binding
    		•  0.0731907516036894 bayes_pls_golite062009
  • lipoprotein binding
    		•  0.02890593650353 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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