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Protein Overview: fab1-PB, fab1-PA

General Information:
Name(s) found: fab1-PB / FBpp0088952 [FlyBase]
fab1-PA / FBpp0088523 [FlyBase]
Description(s) found:
Found 35 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\fab1 (CG6355, FBgn0028741). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13661469..13669417. It has the cytological map location 54E9. There is experimental evidence that it has the molecular function</span>: 1-phosphatidylinositol-3-phosphate 5-kinase activity. There is experimental evidence that it is involved in the biological process</span>: endosome to lysosome transport; phosphoinositide phosphorylation. 4 alleles are reported. The phenotype of these alleles is annotated with: eye disc. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • This gene is referred to in FlyBase by the symbol Dmel\fab1 (CG6355, FBgn0028741). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13661469..13669417. It has the cytological map location 54E9. There is experimental evidence that it has the molecular function</span>: 1-phosphatidylinositol-3-phosphate 5-kinase activity. There is experimental evidence that it is involved in the biological process</span>: endosome to lysosome transport; phosphoinositide phosphorylation. 4 alleles are reported. The phenotype of these alleles is annotated with: eye disc. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1809 amino acids

    Gene Ontology:
    Cellular Component: endosome [IDA]
    vesicle membrane [ISS]
    Biological Process: intracellular signaling pathway [ISS]
    cellular protein metabolic process [IEA]
    phosphoinositide phosphorylation [IMP]
    phosphatidylinositol metabolic process [IEA]
    endosome to lysosome transport [IMP]
    phosphorylation [NAS]
    Molecular Function: ATP binding [IEA]
    zinc ion binding [ISS]
    1-phosphatidylinositol-3-phosphate 5-kinase activity [IMP]
    protein binding [IEA]
    1-phosphatidylinositol-4-phosphate 5-kinase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSNNQNNSS SHQHLHSPSK LTEFARNFED KPESLFGRVV NKIQNVYNQS YNTVNDISSG  60
   61 SSSSSSTQPV QVVGKSQFFS DSQTSTAEIA DVETSSQSSV RPQPPTTLSI RTNSETRGTS 120
  121 TSSNTAAEDS ETSDRVETLP LPTSEANQGR TVSNVLKHIS NIVATKNNND LRNYKDTELQ 180
  181 RFWMPDSKAK ECYDCSQKFS TFRRKHHCRL CGQIFCSKCC NQVVPGMIIR CDGDLKVCNY 240
  241 CSKIVLTFLK SSSSEMGQDM QELQQHLSNK LEVQDSGSSL AKHPQMQRAP LPRKTSVGYQ 300
  301 EERFSSHPTY TTLSIDDRKN ILQQSNSLIT LHEEMQRDLP AQNCGQRLIE FLNSNNKSAN 360
  361 EVQAVAILNA MLAAGFLEPI VPDPEQMDFD SSLHYKFSKS SSSDTSRTMS PQFEANPHAE 420
  421 PQPPKSMDQS AEEKEKELEN ELENDRCYTT ATSKLLASYC EHEEQLLAQM LRAHNLDQEW 480
  481 DKVLQMLCST AANHFKPEHC SNDLMDIRNY VNFKKVPGGR RKDSKIVHGV AFSKNVAHKD 540
  541 MATHVPFPRI LLLQCPIVYE RIEGKFVTIE TVLLQEKEYL RNVCARIMSF KPNVVLVHKN 600
  601 VAGIAQDLLR SYEVTLVLDV KLSVMERLSR TLQCDIVSSI ESNITMPKLG YCNDFYIRNY 660
  661 NGKTLMFFEK LTNPRGYTCL LRGGSNAELT RVKRVASALL FARYNWRLEM SFLLNEFAQP 720
  721 LSPKPSIFDS KETSPKTETE AELRSKRPII LERKSEDKIT TIVSENVSDF TDPLRASQAE 780
  781 ALSTSPCAPP VVEALAVEPR YDNRFRTALS STLLSVSPFL TFPLPYLETE QGRKCKLRKL 840
  841 FPAELYFSKQ WSRTGLERPD SMGDGEAGKS EPGNKENQMQ LLPAHDFVLM KITAPASSRD 900
  901 IQSKLAEFRS FGGRLPKGKA PMLRPKKKNA EVIQRPQKVS EEQLYKDALD PQNHQRLPVL 960
  961 FCSFHYNPKG VSSFCKLPML LDMKFYGQYD IMLEQFLQRY CCLFNSMCPS CNLPMLGHVR1020
 1021 RYVHSLGCVH VYLTEDLTRS DPTRIYFTSW CSICNATTPT IPLSDAAKCL SLAKYLEMRF1080
 1081 HGHAYKRRPP STDAEQGGTV CEHSLHRDYV HHFSFRGVGA KFQYTPVEVW ETDLPSLTVQ1140
 1141 LDLPQPFQSA QVQEEIKNFS IKGHEVYNRI HERIADLATE EENSPLVQHL KTMLTHDQFI1200
 1201 FKQKIEIVHT LLTDNRATAY DTSDALAMAR RALAESIELW GPRLQEIEKL TAKQAHHIDS1260
 1261 GTICTEELRP EQVQTADSSK VTTSSLPKEN DPLECPSEDT ETGASNSQTV LDKNFSIDQM1320
 1321 LASTVNVYSD KKSIRKILTQ LLPSGNQVNP LQSPFPAQDH LTLPLGSIPI HVRETDLSSV1380
 1381 IAYSLTSMDY QKAIDEAEAN SNAAHSSPQL KRKIPLAESV SDAEDSPSLS RTSSNTSAAP1440
 1441 NASVPSPATA ASESEEKSKE RIKQPPSPHI TLAFQDHSCQ FQCKIYFARE FDAMRSKSLK1500
 1501 PPKLDKSLYR RLEKSKMREE LRISQSRTGS EMELVRKPSD VGAPRTTEDD SNQEEDARIA1560
 1561 LARSLCKSVQ WEARGGKSGS RFCKTLDDRF VLKEMNSRDM TIFEPFAPKY FEYIDRCQQQ1620
 1621 QQPTLLAKIF GVFRVSVKKK DSFVERSVMV MENLFYGCNI ENKFDLKGSE RNRLVDPSNQ1680
 1681 QGEIVLLDEN LVQMSWSKPL YVLSHSKTVL RDAIQRDSSF LEKNLVMDYS LLVGLDKKNG1740
 1741 VLVLGIIDYI RTFTLDKRVE SIIKGSGILG GKGKDPTVVN PERYKQRFID AMDRYFLTVP1800
 1801 DRWEGLSKV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..80] deduced N/A No confident structure predictions are available.
    2 View Details [81..254] PSI-BLAST 24.0 Hrs
    3 View Details [255..325] deduced N/A No confident structure predictions are available.
    4 View Details [326..824] PSI-BLAST 119.0 Crystal structure of the chaperonin from Thermococcus strain KS-1 (nucleotide-free form of single mutant)
    5 View Details [825..939] deduced N/A No confident structure predictions are available.
    6 View Details [940..1083] deduced N/A No confident structure predictions are available.
    7 View Details [1084..1256] deduced N/A No confident structure predictions are available.
    8 View Details [1257..1487] MSA 5.127996 View MSA. No confident structure predictions are available.
    9 View Details [1488..1734] PSI-BLAST 63.30103 Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta
    10 View Details [1735..1809] FFAS03 3.09 No description for 2gk9A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • clathrin binding
    		•  4.42433208284373 bayes_pls_golite062009
  • binding
    		•  2.50482426575478 bayes_pls_golite062009
  • protein transporter activity
    		•  1.56162306597345 bayes_pls_golite062009
  • phosphoinositide binding
    		•  1.5307798253901 bayes_pls_golite062009
  • protein binding
    		•  1.42349040268084 bayes_pls_golite062009
  • phospholipid binding
    		•  1.34712325037196 bayes_pls_golite062009
  • transporter activity
    		•  1.32696426532114 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.679696382592776 bayes_pls_golite062009
  • phosphatidylinositol binding
    		•  0.67214549237381 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.578667797495151 bayes_pls_golite062009
  • kinase activity
    		•  0.5474180136682 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.514683355576285 bayes_pls_golite062009
  • DNA binding
    		•  0.443878702795963 bayes_pls_golite062009
  • protein kinase activity
    		•  0.433946621843553 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.374880899986848 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.310675378998881 bayes_pls_golite062009
  • lipid binding
    		•  0.131242568396849 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • 1-phosphatidylinositol-4-phosphate 5-kinase activity
    		•  2.0792241139321 bayes_pls_golite062009
  • binding
    		•  1.64221234725269 bayes_pls_golite062009
  • lipid kinase activity
    		•  1.30654443346559 bayes_pls_golite062009
  • transporter activity
    		•  1.27879339110564 bayes_pls_golite062009
  • phosphatidylinositol phosphate kinase activity
    		•  1.1532371074226 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.08697283907212 bayes_pls_golite062009
  • inositol or phosphatidylinositol kinase activity
    		•  0.957759029487778 bayes_pls_golite062009
  • protein binding
    		•  0.634982583867058 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.609181214178764 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.598076132132183 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.574104967364845 bayes_pls_golite062009
  • kinase activity
    		•  0.56493424031677 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.543285791401512 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.493047135752617 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.479464705542409 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.477091093800976 bayes_pls_golite062009
  • ATPase activity
    		•  0.451768217507419 bayes_pls_golite062009
  • catalytic activity
    		•  0.424959044318554 bayes_pls_golite062009
  • protein transporter activity
    		•  0.376915036228384 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.374469998972096 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.328059756322186 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.275534581026027 bayes_pls_golite062009
  • ATP binding
    		•  0.204730002730195 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.181053338705642 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.178399335304171 bayes_pls_golite062009
  • nucleotide binding
    		•  0.042857134831875 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.0388218369124319 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0360954574704979 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0333062688414986 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.0312484818338645 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.0253141528618308 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.00800704157757948 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9
    Term Confidence Notes
  • 1-phosphatidylinositol-4-phosphate 5-kinase activity
    		•  4.78387945404586 bayes_pls_golite062009
  • inositol or phosphatidylinositol kinase activity
    		•  4.31726963575315 bayes_pls_golite062009
  • lipid kinase activity
    		•  3.63026201392483 bayes_pls_golite062009
  • phosphatidylinositol phosphate kinase activity
    		•  3.5005619620026 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.8512866333787 bayes_pls_golite062009
  • kinase activity
    		•  2.68971389233526 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.31077377326314 bayes_pls_golite062009
  • catalytic activity
    		•  1.87792712964225 bayes_pls_golite062009
  • binding
    		•  1.23659721062619 bayes_pls_golite062009
  • transferase activity
    		•  1.20817067352467 bayes_pls_golite062009
  • signal transducer activity
    		•  0.702573274403091 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.702573274403091 bayes_pls_golite062009
  • ligase activity
    		•  0.435608917599349 bayes_pls_golite062009
  • protein kinase activity
    		•  0.422676745032915 bayes_pls_golite062009
  • protein binding
    		•  0.382966234080422 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.189737258618863 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.14608192065514 bayes_pls_golite062009
    10 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle