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Protein Overview: Sema-1b-PC, Sema...

General Information:
Name(s) found: Sema-1b-PC / FBpp0291371 [FlyBase]
Sema-1b-PB / FBpp0089289 [FlyBase]
Sema-1b-PA / FBpp0086050 [FlyBase]
Description(s) found:
Found 41 descriptions.
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  • The gene Sema-1b is referred to in FlyBase by the symbol Dmel\Sema-1b (CG6446, FBgn0016059). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13560344..13571000. It has the cytological map location 54D4-54D5. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: receptor activity. There is experimental evidence that it is involved in the biological process</span>: embryonic development via the syncytial blastoderm. 9 alleles are reported. The phenotype of these alleles is annotated with: intersegmental nerve. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene Sema-1b is referred to in FlyBase by the symbol Dmel\Sema-1b (CG6446, FBgn0016059). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13560344..13571000. It has the cytological map location 54D4-54D5. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: receptor activity. There is experimental evidence that it is involved in the biological process</span>: embryonic development via the syncytial blastoderm. 9 alleles are reported. The phenotype of these alleles is annotated with: intersegmental nerve. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene Sema-1b is referred to in FlyBase by the symbol Dmel\Sema-1b (CG6446, FBgn0016059). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13560344..13571000. It has the cytological map location 54D4-54D5. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: receptor activity. There is experimental evidence that it is involved in the biological process</span>: embryonic development via the syncytial blastoderm. 9 alleles are reported. The phenotype of these alleles is annotated with: intersegmental nerve. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 770 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [ISS][NAS]
    Biological Process: embryonic development via the syncytial blastoderm [IEP]
    axon guidance [ISS]
    Molecular Function: receptor activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSKSRPSSA AMLVNAIPMI LLITLSGLTI VAGWMPDVKP DLQTKQDKVL AHFIGNSTDY  60
   61 FKILDHNDEF VLVGAKDVIY NVSLNGLKEI ARLEWHSTDA DRELCALKGK HEWDCHNYLR 120
  121 VYALRPNGEV LLCGTNSYKP RCRHYTPVEV SSEEAGSAGH AHAMRYEVSR DVEAQGLCPY 180
  181 SPAHNSTYAF ADGHLYSATV ADFSGGDPLI YRENLRTEQY DLKQLNQPDF VGAIERNGYV 240
  241 LFFFRELSME VMNFGKAVYS RVARVCKNDR GGPYSHGKSW TSFLKARLNC SVPGEFPFYF 300
  301 DEIQAISPIV ESGSKSLIYA VFTTSVNAIP GSAVCAFNVD DILAAFDGEF KSQKDSQSHW 360
  361 LPVEREQVPK PRPGQCVEDS RTLTSIAVNF IKNHPLMEEA VPAVHGRPLL TKVNLHHRLT 420
  421 AIAVHPQVKS LSGAYYDVIY SGTDDGKVTK FINILSTHPN STVDRLKTVV ISEMQVLPLG 480
  481 TPIRELVIST SKNSLVVVSD GSLVSVPLHH CSHIVDCLGC LSLQDPICAW DLQTHECKNL 540
  541 ATSQHKFGTK TYLQSLNSTK KAAALLCPHI PRDAPGAETV SFVTMAPPPT EEQKLLYSNV 600
  601 GSSQGNQPSL EQQPTGGDDF GLNKITLTSM DPDDIMPNLN DPQKSTASVD EIKYASTPSF 660
  661 MLLTTIVFFT FLVGGIAGIC CVKAKSRLME AQMDESHRNH FGKPMQFKHQ NTGKDINLLM 720
  721 GSNAYTTTQK TPNLDLEKDR SHECKNSTEH LEKELPCKTS TLTKVKRTYI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..673] PSI-BLAST 132.0 The ligand-binding face of the semaphorins revealed by the high resolution crystal structure of SEMA4D
    2 View Details [674..770] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • antigen binding
    		•  3.72597633672466 bayes_pls_golite062009
  • receptor activity
    		•  1.72641278961515 bayes_pls_golite062009
  • peptide antigen binding
    		•  1.66960790017756 bayes_pls_golite062009
  • binding
    		•  1.4212448680573 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  1.25652075776666 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.15635912144616 bayes_pls_golite062009
  • protein binding
    		•  1.15274187225647 bayes_pls_golite062009
  • receptor binding
    		•  0.85968680895393 bayes_pls_golite062009
  • signal transducer activity
    		•  0.791510332487796 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.791510332487796 bayes_pls_golite062009
  • immunoglobulin binding
    		•  0.48272957113121 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.31988469097193 bayes_pls_golite062009
  • MHC class II receptor activity
    		•  0.251167772391909 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  0.15810089914274 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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