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Protein Overview: FBpp0297513, Rpn6-PB

General Information:
Name(s) found: FBpp0297513 [FlyBase]
Rpn6-PB / FBpp0086604 [FlyBase]
Description(s) found:
Found 34 descriptions.
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  • type=protein; loc=2R:complement(10637991..10638221,10638288..10638500,10638650..10639156,10639221..10639538); ID=FBpp0297513; name=Rpn6-PC; parent=FBgn0028689,FBtr0306558; dbxref=REFSEQ:NP_001246325,GB_protein:AFH08079,FlyBase:FBpp0297513,FlyBase_Annotation_IDs:CG10149-PC; MD5=92919412e8606c581d62471b9a50d20b; length=422; release=r5.56; species=Dmel; [FlyBase]
  • The gene Proteasome p44.5 subunit is referred to in FlyBase by the symbol Dmel\Rpn6 (CG10149, FBgn0028689). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10637656..10640415. It has the cytological map location 51C1-51C2. There is experimental evidence that it has the molecular function</span>: endopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: proteolysis. 12 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 422 amino acids

    Gene Ontology:
    Cellular Component: proteasome regulatory particle [IDA][ISS]
    proteasome regulatory particle, lid subcomplex [ISS][NAS]
    Biological Process: proteolysis [IDA][ISS]
    Molecular Function: endopeptidase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGATLFERA QALSSVNREE QDSSLLNKLV RDQEGAENDE ERIRIKEQGI LQQGELYKQE  60
   61 GKAKELADLI KVTRPFLSSI SKAKAAKLVR SLVDMFLDMD AGTGIEVQLC KDCIEWAKQE 120
  121 KRTFLRQSLE ARLIALYFDT ALYTEALALG AQLLRELKKL DDKNLLVEVQ LLESKTYHAL 180
  181 SNLPKARAAL TSARTTANAI YCPPKVQGAL DLQSGILHAA DERDFKTAFS YFYEAFEGFD 240
  241 SVDSVKALTS LKYMLLCKIM LGQSDDVNQL VSGKLAITYS GRDIDAMKSV AEASHKRSLA 300
  301 DFQAALKEYK KELAEDVIVQ AHLGTLYDTM LEQNLCRIIE PYSRVQVAHV AESIQLPMPQ 360
  361 VEKKLSQMIL DKKFSGILDQ GEGVLIVFEE TPVDKTYERV LETIQSMGKV VDTLYQKAKK 420
  421 LS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..240] PSI-BLAST 10.0 Crystal structure of an 8 repeat consensus TPR superhelix (trigonal crystal form)
    2 View Details [241..304] deduced N/A No confident structure predictions are available.
    3 View Details [305..422] PSI-BLAST 8.522879 Solution structure of the PCI domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  3.50995556050336 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.38144578566524 bayes_pls_golite062009
  • binding
    		•  3.33026160538031 bayes_pls_golite062009
  • DNA binding
    		•  3.30822066787723 bayes_pls_golite062009
  • transcription factor activity
    		•  2.60537570879007 bayes_pls_golite062009
  • hydrolase activity
    		•  2.30467124306022 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.46680509390433 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.32971938164691 bayes_pls_golite062009
  • transcription activator activity
    		•  1.08566311616647 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.95491822926452 bayes_pls_golite062009
  • protein binding
    		•  0.653872239015235 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.42135864069093 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.136726704233672 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.118016217031359 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle