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Protein Overview: cg-PC

General Information:
Name(s) found: cg-PC / FBpp0086657 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene combgap is referred to in FlyBase by the symbol Dmel\cg (CG8367, FBgn0000289). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10061175..10070345. It has the cytological map location 50E1. It is reported to have molecular function</span>: transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: imaginal disc-derived wing morphogenesis. 30 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: adult segment; organ system; adult mesothoracic segment; thoracic segment; nervous system; peripheral nervous system; mushroom body; antennal segment; larval thorax; metatarsus. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 629 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    Biological Process: imaginal disc-derived wing morphogenesis [IMP]
    Molecular Function: nucleic acid binding [IEA]
    transcription factor activity [NAS]
    zinc ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPYLLSTDGS LAVQKDVKGL TAGGKNNVVR RMFVVNDPSF PPGTQRVITA GGASTVVKKQ  60
   61 DNNQQVLSLD KNCDILPGIS VQVQKVIQGL EDNEDSQGEA PNLKLEPGTL ELSPKTELQE 120
  121 SMHFSETDAT IKKERPYSCD ECGKSFLLKH HLTTHARVHT GERPHICTHC GKSFAHKHCL 180
  181 NTHLLLHSTE RPYQCQECKK SFTLKHHLLT HSRVHSRERP FVCQECGRAF PLKRHLVTHS 240
  241 KFHAGERPYV CEECGESFAQ ENHLIMHSRF HGSLNPFVCA ECGASFPRKF QLVNHGRIHG 300
  301 KIPHSCTVCG KEFLQKRTLV SHMRRVHTGE QAHPCVSCGE GFLTKAELHQ HVRTAHNGVN 360
  361 PNTSSATIIA NQQLQQAHHH QAGQQTHPQT ITVVSNPGNS TLLTVSTTDA NGVARPQFVC 420
  421 RECGSAFNSR EALALHLRLH TGDKSLMTDL CALTAALPGH FLSTASLNPG TVVTANPNLV 480
  481 GQSPVPVQII SSTGQVMSQT TLVQAANSTH PQAVVTAVPT MPVHGQQQHL QHVAQQQQQQ 540
  541 QQQQQQQQQH VVSVAPANKP KSHFCASCGK GFAAKHGLMQ HNRRHPNGGC TVRTHVCECG 600
  601 KAFFQKNHLM LHQRQHLETK PAISQQQVC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..119] deduced N/A No confident structure predictions are available.
    2 View Details [120..302] PSI-BLAST 61.30103 No description for 2i13A was found.
    3 View Details [303..350] FFAS03 3.56 No description for 2dlqA was found.
    4 View Details [351..459] PSI-BLAST 16.522879 TATA box-binding zinc finger, TATAZF
    5 View Details [460..523] deduced N/A No confident structure predictions are available.
    6 View Details [524..629] PSI-BLAST 8.09691 Solution structures of the C2H2 type zinc finger domain of human Transcriptional repressor CTCF

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  4.47951889934838 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.35187767955595 bayes_pls_golite062009
  • DNA binding
    		•  4.31051339571017 bayes_pls_golite062009
  • transcription factor activity
    		•  3.28758716579796 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.07956158665183 bayes_pls_golite062009
  • binding
    		•  2.99742524370422 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.96255357208943 bayes_pls_golite062009
  • transcription activator activity
    		•  1.97757778483124 bayes_pls_golite062009
  • chromatin binding
    		•  1.91511881662436 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.35857850481346 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.33097016250582 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.26862497534835 bayes_pls_golite062009
  • transcription factor binding
    		•  1.23738346570539 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.16887811832337 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.00239065862819 bayes_pls_golite062009
  • protein binding
    		•  0.952480850696098 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.627794176881836 bayes_pls_golite062009
  • catalytic activity
    		•  0.263007611601737 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • transcription regulator activity
    		•  4.70988788192472 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.58713908116892 bayes_pls_golite062009
  • DNA binding
    		•  4.56219307357342 bayes_pls_golite062009
  • transcription factor activity
    		•  3.50954949535763 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.27542149084008 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22082323675675 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • transcription activator activity
    		•  2.19952417915035 bayes_pls_golite062009
  • chromatin binding
    		•  2.18464662431232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.63161912031789 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.48624530884061 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.42975942698743 bayes_pls_golite062009
  • transcription factor binding
    		•  1.39608963544799 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.34049786451995 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.18599503594288 bayes_pls_golite062009
  • protein binding
    		•  1.00484935878505 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.77874411480713 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle