Protein Overview: cg-PC

General Information:
Name(s) found:	cg-PC / FBpp0086657 [FlyBase]
Description(s) found: Found 19 descriptions. SHOW ALL	The gene combgap is referred to in FlyBase by the symbol Dmel\cg (CG8367, FBgn0000289). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10061175..10070345. It has the cytological map location 50E1. It is reported to have molecular function</span>: transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: imaginal disc-derived wing morphogenesis. 30 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: adult segment; organ system; adult mesothoracic segment; thoracic segment; nervous system; peripheral nervous system; mushroom body; antennal segment; larval thorax; metatarsus. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	629 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA][NAS]
Biological Process:	imaginal disc-derived wing morphogenesis [IMP]
Molecular Function:	nucleic acid binding [IEA] transcription factor activity [NAS] zinc ion binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPYLLSTDGS LAVQKDVKGL TAGGKNNVVR RMFVVNDPSF PPGTQRVITA GGASTVVKKQ  60
   61 DNNQQVLSLD KNCDILPGIS VQVQKVIQGL EDNEDSQGEA PNLKLEPGTL ELSPKTELQE 120
  121 SMHFSETDAT IKKERPYSCD ECGKSFLLKH HLTTHARVHT GERPHICTHC GKSFAHKHCL 180
  181 NTHLLLHSTE RPYQCQECKK SFTLKHHLLT HSRVHSRERP FVCQECGRAF PLKRHLVTHS 240
  241 KFHAGERPYV CEECGESFAQ ENHLIMHSRF HGSLNPFVCA ECGASFPRKF QLVNHGRIHG 300
  301 KIPHSCTVCG KEFLQKRTLV SHMRRVHTGE QAHPCVSCGE GFLTKAELHQ HVRTAHNGVN 360
  361 PNTSSATIIA NQQLQQAHHH QAGQQTHPQT ITVVSNPGNS TLLTVSTTDA NGVARPQFVC 420
  421 RECGSAFNSR EALALHLRLH TGDKSLMTDL CALTAALPGH FLSTASLNPG TVVTANPNLV 480
  481 GQSPVPVQII SSTGQVMSQT TLVQAANSTH PQAVVTAVPT MPVHGQQQHL QHVAQQQQQQ 540
  541 QQQQQQQQQH VVSVAPANKP KSHFCASCGK GFAAKHGLMQ HNRRHPNGGC TVRTHVCECG 600
  601 KAFFQKNHLM LHQRQHLETK PAISQQQVC

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..119]	deduced	N/A	No confident structure predictions are available.
2	View Details	[120..302]	PSI-BLAST	61.30103	No description for 2i13A was found.
3	View Details	[303..350]	FFAS03	3.56	No description for 2dlqA was found.
4	View Details	[351..459]	PSI-BLAST	16.522879	TATA box-binding zinc finger, TATAZF
5	View Details	[460..523]	deduced	N/A	No confident structure predictions are available.
6	View Details	[524..629]	PSI-BLAST	8.09691	Solution structures of the C2H2 type zinc finger domain of human Transcriptional repressor CTCF

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

No functions predicted.

3

Term	Confidence	Notes
transcription regulator activity	4.47951889934838	bayes_pls_golite062009
nucleic acid binding	4.35187767955595	bayes_pls_golite062009
DNA binding	4.31051339571017	bayes_pls_golite062009
transcription factor activity	3.28758716579796	bayes_pls_golite062009
transcription repressor activity	3.07956158665183	bayes_pls_golite062009
binding	2.99742524370422	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.96255357208943	bayes_pls_golite062009
transcription activator activity	1.97757778483124	bayes_pls_golite062009
chromatin binding	1.91511881662436	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.35857850481346	bayes_pls_golite062009
structure-specific DNA binding	1.33097016250582	bayes_pls_golite062009
sequence-specific DNA binding	1.26862497534835	bayes_pls_golite062009
transcription factor binding	1.23738346570539	bayes_pls_golite062009
transcription corepressor activity	1.16887811832337	bayes_pls_golite062009
double-stranded DNA binding	1.00239065862819	bayes_pls_golite062009
protein binding	0.952480850696098	bayes_pls_golite062009
transcription cofactor activity	0.627794176881836	bayes_pls_golite062009
catalytic activity	0.263007611601737	bayes_pls_golite062009

4

No functions predicted.

5

No functions predicted.

6

Term	Confidence	Notes
transcription regulator activity	4.70988788192472	bayes_pls_golite062009
nucleic acid binding	4.58713908116892	bayes_pls_golite062009
DNA binding	4.56219307357342	bayes_pls_golite062009
transcription factor activity	3.50954949535763	bayes_pls_golite062009
transcription repressor activity	3.27542149084008	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.22082323675675	bayes_pls_golite062009
binding	3.10743787485868	bayes_pls_golite062009
transcription activator activity	2.19952417915035	bayes_pls_golite062009
chromatin binding	2.18464662431232	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.63161912031789	bayes_pls_golite062009
structure-specific DNA binding	1.48624530884061	bayes_pls_golite062009
sequence-specific DNA binding	1.42975942698743	bayes_pls_golite062009
transcription factor binding	1.39608963544799	bayes_pls_golite062009
transcription corepressor activity	1.34049786451995	bayes_pls_golite062009
double-stranded DNA binding	1.18599503594288	bayes_pls_golite062009
protein binding	1.00484935878505	bayes_pls_golite062009
transcription cofactor activity	0.77874411480713	bayes_pls_golite062009
catalytic activity	0.245893663605433	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

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