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Protein Overview: cg-PA, cg-PD

General Information:
Name(s) found: cg-PA / FBpp0086658 [FlyBase]
cg-PD / FBpp0086655 [FlyBase]
Description(s) found:
Found 39 descriptions.
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  • The gene combgap is referred to in FlyBase by the symbol Dmel\cg (CG8367, FBgn0000289). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10061175..10070345. It has the cytological map location 50E1. It is reported to have molecular function</span>: transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: imaginal disc-derived wing morphogenesis. 30 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: adult segment; organ system; adult mesothoracic segment; thoracic segment; nervous system; peripheral nervous system; mushroom body; antennal segment; larval thorax; metatarsus. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
  • The gene combgap is referred to in FlyBase by the symbol Dmel\cg (CG8367, FBgn0000289). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10061175..10070345. It has the cytological map location 50E1. It is reported to have molecular function</span>: transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: imaginal disc-derived wing morphogenesis. 30 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: adult segment; organ system; adult mesothoracic segment; thoracic segment; nervous system; peripheral nervous system; mushroom body; antennal segment; larval thorax; metatarsus. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 671 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    Biological Process: imaginal disc-derived wing morphogenesis [IMP]
    Molecular Function: nucleic acid binding [IEA]
    transcription factor activity [NAS]
    zinc ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCAAQNPPPF GYTWGFADNG NRAAESVLEI SPNINYTVSG ESMPYLLSTD GSLAVQKDVK  60
   61 GLTAGGKNNV VRRMFVVNDP SFPPGTQRVI TAGGASTVVK KQDNNQQVLS LDKNCDILPG 120
  121 ISVQVQKVIQ GLEDNEDSQG EAPNLKLEPG TLELSPKTEL QESMHFSETD ATIKKERPYS 180
  181 CDECGKSFLL KHHLTTHARV HTGERPHICT HCGKSFAHKH CLNTHLLLHS TERPYQCQEC 240
  241 KKSFTLKHHL LTHSRVHSRE RPFVCQECGR AFPLKRHLVT HSKFHAGERP YVCEECGESF 300
  301 AQENHLIMHS RFHGSLNPFV CAECGASFPR KFQLVNHGRI HGKIPHSCTV CGKEFLQKRT 360
  361 LVSHMRRVHT GEQAHPCVSC GEGFLTKAEL HQHVRTAHNG VNPNTSSATI IANQQLQQAH 420
  421 HHQAGQQTHP QTITVVSNPG NSTLLTVSTT DANGVARPQF VCRECGSAFN SREALALHLR 480
  481 LHTGDKSLMT DLCALTAALP GHFLSTASLN PGTVVTANPN LVGQSPVPVQ IISSTGQVMS 540
  541 QTTLVQAANS THPQAVVTAV PTMPVHGQQQ HLQHVAQQQQ QQQQQQQQQQ QHVVSVAPAN 600
  601 KPKSHFCASC GKGFAAKHGL MQHNRRHPNG GCTVRTHVCE CGKAFFQKNH LMLHQRQHLE 660
  661 TKPAISQQQV C

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..144] deduced N/A No confident structure predictions are available.
    2 View Details [145..350] PSI-BLAST 60.69897 No description for 2i13A was found.
    3 View Details [351..515] PSI-BLAST 19.09691 Five-finger GLI1
    4 View Details [516..671] PSI-BLAST 5.045757 THE CRYSTAL STRUCTURE OF A ZINC FINGER - RNA COMPLEX REVEALS TWO MODES OF MOLECULAR RECOGNITION

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  4.70988788192472 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.58713908116892 bayes_pls_golite062009
  • DNA binding
    		•  4.56219307357342 bayes_pls_golite062009
  • transcription factor activity
    		•  3.50954949535763 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.27542149084008 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22082323675675 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • transcription activator activity
    		•  2.19952417915035 bayes_pls_golite062009
  • chromatin binding
    		•  2.18464662431232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.63161912031789 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.48624530884061 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.42975942698743 bayes_pls_golite062009
  • transcription factor binding
    		•  1.39608963544799 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.34049786451995 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.18599503594288 bayes_pls_golite062009
  • protein binding
    		•  1.00484935878505 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.77874411480713 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle