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View Structure Prediction Details

Protein: cg-PA, cg-PD
Organism: Drosophila melanogaster
Length: 671 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cg-PA, cg-PD.

Description E-value Query
Range
Subject
Range
gi|76651072 - gi|76651072|ref|XP_887921.1| PREDICTED: similar to zinc finger protein 192 isoform 7 [Bos taurus]
811.0 [0..19] [662..323]

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Predicted Domain #1
Region A:
Residues: [1-144]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCAAQNPPPF GYTWGFADNG NRAAESVLEI SPNINYTVSG ESMPYLLSTD GSLAVQKDVK  60
   61 GLTAGGKNNV VRRMFVVNDP SFPPGTQRVI TAGGASTVVK KQDNNQQVLS LDKNCDILPG 120
  121 ISVQVQKVIQ GLEDNEDSQG EAPN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [145-350]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKLEPGTLEL SPKTELQESM HFSETDATIK KERPYSCDEC GKSFLLKHHL TTHARVHTGE  60
   61 RPHICTHCGK SFAHKHCLNT HLLLHSTERP YQCQECKKSF TLKHHLLTHS RVHSRERPFV 120
  121 CQECGRAFPL KRHLVTHSKF HAGERPYVCE ECGESFAQEN HLIMHSRFHG SLNPFVCAEC 180
  181 GASFPRKFQL VNHGRIHGKI PHSCTV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 60.69897
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #3
Region A:
Residues: [351-515]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CGKEFLQKRT LVSHMRRVHT GEQAHPCVSC GEGFLTKAEL HQHVRTAHNG VNPNTSSATI  60
   61 IANQQLQQAH HHQAGQQTHP QTITVVSNPG NSTLLTVSTT DANGVARPQF VCRECGSAFN 120
  121 SREALALHLR LHTGDKSLMT DLCALTAALP GHFLSTASLN PGTVV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.09691
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
structure-specific DNA binding 1.48624530884061 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
double-stranded DNA binding 1.18599503594288 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [516-671]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TANPNLVGQS PVPVQIISST GQVMSQTTLV QAANSTHPQA VVTAVPTMPV HGQQQHLQHV  60
   61 AQQQQQQQQQ QQQQQQHVVS VAPANKPKSH FCASCGKGFA AKHGLMQHNR RHPNGGCTVR 120
  121 THVCECGKAF FQKNHLMLHQ RQHLETKPAI SQQQVC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.045757
Match: 1un6B
Description: THE CRYSTAL STRUCTURE OF A ZINC FINGER - RNA COMPLEX REVEALS TWO MODES OF MOLECULAR RECOGNITION
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle