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View Structure Prediction Details

Protein: cg-PA, cg-PD
Organism: Drosophila melanogaster
Length: 671 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cg-PA, cg-PD.

Description E-value Query
Range
Subject
Range
gi|76651072 - gi|76651072|ref|XP_887921.1| PREDICTED: similar to zinc finger protein 192 isoform 7 [Bos taurus]
811.0 [0..19] [662..323]

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Predicted Domain #1
Region A:
Residues: [1-144]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCAAQNPPPF GYTWGFADNG NRAAESVLEI SPNINYTVSG ESMPYLLSTD GSLAVQKDVK  60
   61 GLTAGGKNNV VRRMFVVNDP SFPPGTQRVI TAGGASTVVK KQDNNQQVLS LDKNCDILPG 120
  121 ISVQVQKVIQ GLEDNEDSQG EAPN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [145-350]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKLEPGTLEL SPKTELQESM HFSETDATIK KERPYSCDEC GKSFLLKHHL TTHARVHTGE  60
   61 RPHICTHCGK SFAHKHCLNT HLLLHSTERP YQCQECKKSF TLKHHLLTHS RVHSRERPFV 120
  121 CQECGRAFPL KRHLVTHSKF HAGERPYVCE ECGESFAQEN HLIMHSRFHG SLNPFVCAEC 180
  181 GASFPRKFQL VNHGRIHGKI PHSCTV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 60.69897
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #3
Region A:
Residues: [351-515]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CGKEFLQKRT LVSHMRRVHT GEQAHPCVSC GEGFLTKAEL HQHVRTAHNG VNPNTSSATI  60
   61 IANQQLQQAH HHQAGQQTHP QTITVVSNPG NSTLLTVSTT DANGVARPQF VCRECGSAFN 120
  121 SREALALHLR LHTGDKSLMT DLCALTAALP GHFLSTASLN PGTVV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.09691
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
structure-specific DNA binding 1.48624530884061 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
double-stranded DNA binding 1.18599503594288 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [516-671]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TANPNLVGQS PVPVQIISST GQVMSQTTLV QAANSTHPQA VVTAVPTMPV HGQQQHLQHV  60
   61 AQQQQQQQQQ QQQQQQHVVS VAPANKPKSH FCASCGKGFA AKHGLMQHNR RHPNGGCTVR 120
  121 THVCECGKAF FQKNHLMLHQ RQHLETKPAI SQQQVC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.045757
Match: 1un6B
Description: THE CRYSTAL STRUCTURE OF A ZINC FINGER - RNA COMPLEX REVEALS TWO MODES OF MOLECULAR RECOGNITION
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle