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Protein Overview: Den1-PA

General Information:
Name(s) found: Den1-PA / FBpp0087013 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • The gene Deneddylase 1 is referred to in FlyBase by the symbol Dmel\Den1 (CG8493, FBgn0033716). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8225307..8227050. It has the cytological map location 48F10. There is experimental evidence that it has the molecular function</span>: NEDD8-specific protease activity. There is experimental evidence that it is involved in the biological process</span>: protein deneddylation. 9 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 215 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: proteolysis [IEA]
    protein deneddylation [IDA]
    Molecular Function: NEDD8-specific protease activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSNSKADPI SLTFHDSCLR MSDVQLLHGP HWLNDQILSF YYEYLAHMKY KTNADLHFIA  60
   61 PEITQCMKYM GDQELKQLLD QSNTTGKPFI FFALNDNETT DAGGSHWSLL VFSRPEKTFY 120
  121 HFDSYGNNNT GNSLELMNKI KDLLGVRMAK FRPMRCLQQA NGYDCGIHVI CMTDHIADYL 180
  181 NRYEVIDGLP SLHIDTVKAK RTELLKLILS LGGKG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] PSI-BLAST 35.69897 NEDD8 protease

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cysteine-type peptidase activity
    		•  5.93560668185539 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  5.48721952122524 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  4.73623517114533 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  3.38737606974088 bayes_pls_golite062009
  • thiolester hydrolase activity
    		•  1.90178501880966 bayes_pls_golite062009
  • SUMO-specific protease activity
    		•  1.6602460763044 bayes_pls_golite062009
  • peptidase activity
    		•  1.39702589518384 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  1.28597643058503 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • protein binding
    		•  0.755467947031123 bayes_pls_golite062009
  • hydrolase activity
    		•  0.612664640888088 bayes_pls_golite062009
  • binding
    		•  0.426262567794169 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.366512660710683 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  0.125393771316362 bayes_pls_golite062009
  • NEDD8-specific protease activity
    		•  0.09564496961635 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle