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Protein Overview: otk-PA

General Information:
Name(s) found: otk-PA / FBpp0087135 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene off-track is referred to in FlyBase by the symbol Dmel\otk (CG8967, FBgn0004839). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:7888983..7907329. It has the cytological map location 48D6-48D7. There is experimental evidence that it has the molecular function</span>: cell adhesion molecule binding; receptor activity; protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: axon guidance; cell adhesion. 15 alleles are reported. The phenotypes of these alleles are annotated with: intersegmental nerve; abdominal segmental nerve; axon. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1033 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDA]
    Biological Process: axon guidance [IGI][IMP]
    cell adhesion [IDA][ISS]
    protein amino acid phosphorylation [IEA][NAS]
    Molecular Function: ATP binding [IEA]
    protein tyrosine kinase activity [ISS][NAS]
    transmembrane receptor protein tyrosine kinase activity [ISS]
    cell adhesion molecule binding [IDA][ISS]
    protein kinase activity [IDA]
    receptor activity [IDA][ISS]
    semaphorin receptor binding [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTARMISICG LVMALMMASV LASSSRFQRV PQSQSVVENE SVKFECESTD SYSELHYDWL  60
   61 HNGHRIAYDK RVHQIGSNLH IEAVRRTEDV GNYVCIATNL ASGAREASPP AKLSVIYLES 120
  121 ASVQLLGSNR NELLLKCHVE GASGDLEPLE IEWYRNSEKL STWKNVQLDQ HRLIIRQPGS 180
  181 EDDGLYRCTA SNAAGRVMSK QGYVYQSSVK CLPRLPRRKN EKMMESWDKQ TFLCRGKRGG 240
  241 AAGLEALPAA PEDLRIVQGP IGQSIIKEGE PTALTCLYEL PDELKNQRIQ LRWRKDGKLL 300
  301 RQVELGGSAP IPGHSFDSGK DALLREDARL VLHKQNGTLS FASIIASDAG QYQCQLQLEA 360
  361 HAPINSSPGI LEVIEQLKFV PQPTSKNLEL DAVVAKVHCK AQGTPTPQVQ WVRDGENTTL 420
  421 PDHVEVDANG TLIFRNVNSE HRGNYTCLAT NSQGQINATV AINVVVTPKF SVPPVGPIET 480
  481 SEQGTVVMHC QAIGDPKPTI QWDKDLKYLS ENNTDRERFR FLENGTLEIR NVQVEDEGSY 540
  541 GCTIGNSAGL KREDVQLVVK TTGDGFAPEE SGGDGFLVTR AVLITMTVAL AYIVLVVGLM 600
  601 LWCRYRRQAR KARLNDLSTK EAGGDQPDVA GNGKGSEQEP CLSKQHNGHS KSRSKSSGDA 660
  661 QKSDDTACSQ QSRASKKSAH IYEQLALPRS GLSELIQIGR GEFGDVFVGK LKATLVTSPS 720
  721 DKDADTEKQH SNSENGSGGS GSGSTTLSTL NEKRRSKTSM DDIEEIKEEE QDQHNQSGLE 780
  781 QLVLVKALNK VKDEQACQEF RRQLDLLRAI SHKGVVRLFG LCREKDPHYM VLEYTDWGDL 840
  841 KQFLLATAGK VNTATAGSSS PPPLTTSQVL AVAYQIARGM DAIYRARFTH RDLATRNCVI 900
  901 SSEFIVKVSY PALCKDKYSR EYHKHRNTLL PIRWLAPECI QEDEYTTKSD IFAYGVVVWE 960
  961 LFNQATKLPH EELTNEQVVQ RSQAGSLEWS VAEATPDSLR EILLSCWVSN PKERPSFSQL1020
 1021 GAALSKAMQS AEK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..604] PSI-BLAST 58.30103 Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
    2 View Details [605..685] deduced N/A No confident structure predictions are available.
    3 View Details [686..736] FFAS03 2.25 Carboxyl-terminal src kinase (csk)
    4 View Details [737..1033] PSI-BLAST 52.154902 Musk tyrosine kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • protein kinase activity
    		•  5.63683237027974 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.24105099841813 bayes_pls_golite062009
  • kinase activity
    		•  5.02394449930162 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.38615595541751 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.33927583810751 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • binding
    		•  2.10874590528357 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.66669268613198 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.10045286406485 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.10045286406485 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.74324450025139 bayes_pls_golite062009
  • transporter activity
    		•  0.710766490066447 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.60324822483033 bayes_pls_golite062009
  • activin binding
    		•  0.510364757301021 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.385603245903806 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.371991354471077 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  0.33808087202461 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.310771535422373 bayes_pls_golite062009
  • kinase binding
    		•  0.26752427107238 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.152203945257581 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.0675236791909441 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  0.0393215018817107 bayes_pls_golite062009
  • protein kinase binding
    		•  0.00674998152095019 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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