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Protein Overview: FBpp0309831, lola-PI

General Information:
Name(s) found: FBpp0309831 [FlyBase]
lola-PI / FBpp0088384 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • type=protein; loc=2R:complement(6395852..6397059,6397300..6397641,6419544..6419624,6419686..6420399,6420623..6421016,6421081..6421254); ID=FBpp0309831; name=lola-PAA; parent=FBgn0005630,FBtr0343132; dbxref=FlyBase:FBpp0309831,FlyBase_Annotation_IDs:CG12052-PAA; MD5=e16eb2e3f8678acf76e152bbcc6c210a; length=970; release=r5.56; species=Dmel; [FlyBase]
  • The gene longitudinals lacking is referred to in FlyBase by the symbol Dmel\lola (CG12052, FBgn0005630). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:6369712..6430767. It has the cytological map location 47A11-47A13. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: anatomical structure development; cell projection organization; cellular component movement; behavior; sensory organ development; organ morphogenesis; immune response; programmed cell death; neuromuscular process; behavioral interaction between organisms; locomotory behavior; regulation of metabolic process. 163 alleles are reported. The phenotypes of these alleles are annotated with 40 unique terms, many of which group under: peripheral nervous system; nervous system; abdominal lateral monoscolopidial chordotonal organ lch1; embryonic neuron; embryonic nervous system; organ system; multi-cell-component structure; adult segment; abdominal longitudinal muscle; ventral longitudinal muscle. It has 26 annotated transcripts and 26 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 970 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    Biological Process: regulation of gene-specific transcription [IMP]
    R7 cell development [IMP]
    axon guidance [IGI][IMP][NAS]
    nurse cell apoptosis [IMP]
    brain morphogenesis [IMP]
    R3/R4 cell fate commitment [IMP]
    inter-male aggressive behavior [IMP]
    regulation of transcription from RNA polymerase II promoter [NAS]
    locomotion involved in locomotory behavior [IMP]
    startle response [IMP]
    positive regulation of transcription, DNA-dependent [ISS]
    axonogenesis [IMP]
    axon midline choice point recognition [IGI][IMP]
    antimicrobial humoral response [IMP]
    Molecular Function: zinc ion binding [IEA]
    protein binding [IPI]
    RNA polymerase II transcription factor activity [NAS]
    specific RNA polymerase II transcription factor activity [ISS][NAS]
    transcription activator activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDDQQFCLR WNNHQSTLIS VFDTLLENET LVDCTLAAEG KFLKAHKVVL SACSPYFATL  60
   61 LQEQYDKHPI FILKDVKYQE LRAMMDYMYR GEVNISQDQL AALLKAAESL QIKGLSDNRT 120
  121 GGGVAPKPES SGHHRGGKLS GAYTLEQTKR ARLATGGAMD TSGDVSGSRE GSSSPSRRRR 180
  181 KVRRRSMEND AHDNSNSSVL QAAASNQSIL QQTGAGLAVS ALVTTQLSSG PAAGTSSQAS 240
  241 STQQQQPLTS TNVTKKTESA KLTSSTAAPA SGASASAAVQ QAHLHQQQAQ TTSDAINTEN 300
  301 VQAQSQGGAQ GVQGDDEDID EGSAVGGPNS ATGPNPASAS ASAVHAGVVV KQLASVVDKS 360
  361 SSNHKHKIKD NSVSSVGSEM VIEPKAEYDD DAHDENVEDL TLDEEDMTME ELDQTAGTSQ 420
  421 GGEGSSQTYA TWQHDRSQDE LGLMAQDAQQ RDPQASKQDK GEQTEGAQDE FELDDCLLES 480
  481 NDIVITQNKD GFVLHVKKLG NITAAKLEEN QAVAQQQGQA AVTVTGPAGQ PTPTITELLN 540
  541 AAAASHSEPK PTLTTLTSTP IKLPSSECEL INIKKIIPAT TTIATHHPHT SSTIIHPHHI 600
  601 IQHVSQEPHH QEHHQQHQTI HIEEVPQTSQ QHHQQQHHHQ LQTVQPTHTQ VQSIITAHPG 660
  661 QTINLVGLRN VQLADSKPIA SRIRYSRGKI IGPTVQNLQI VETHEPIQHQ HHELSDGTKY 720
  721 EISEIDLNNP NASAAIISDL VKYAEIDDIE LPDGTKIGIG FAPSEITEHM QTSGGETHIT 780
  781 TIEHEPQELQ TVHQHEQTQQ THHIHAGQLQ THHIQTVVQS SSGQQQHDQQ QHHQHHSIEL 840
  841 QDDDGVETIT PEELGMHDSS KSYTILTTRP MKEESEHDPS GMTYELSLSD SSLGPCDDPE 900
  901 SRYVCRHCGK KYRWKSTLRR HENVECGGKE PCHPCPYCSY KAKQRGNLGV HVRKHHPEKP 960
  961 QLESKRGRKV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..123] PSI-BLAST 33.69897 No description for 2nn2A was found.
    2 View Details [124..286] deduced N/A No confident structure predictions are available.
    3 View Details [287..465] deduced N/A No confident structure predictions are available.
    4 View Details [466..623] PSI-BLAST 9.39794 Transcription factor IIIA, TFIIIA
    5 View Details [624..720] MSA 3.571991 View MSA. No confident structure predictions are available.
    6 View Details [721..970] PSI-BLAST 52.522879 No description for 2i13A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • transcription regulator activity
    		•  4.70988788192472 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.58713908116892 bayes_pls_golite062009
  • DNA binding
    		•  4.56219307357342 bayes_pls_golite062009
  • transcription activator activity
    		•  3.52873291636993 bayes_pls_golite062009
  • transcription factor activity
    		•  3.50954949535763 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.27542149084008 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22082323675675 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.53101891154822 bayes_pls_golite062009
  • chromatin binding
    		•  2.18464662431232 bayes_pls_golite062009
  • protein binding
    		•  2.05530362750351 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.63161912031789 bayes_pls_golite062009
  • transcription factor binding
    		•  1.39608963544799 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.34049786451995 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.77874411480713 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle