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Protein Overview: Jra-PB, Jra-PA

General Information:
Name(s) found: Jra-PA / FBpp0087499 [FlyBase]
Jra-PB / FBpp0087498 [FlyBase]
Description(s) found:
Found 36 descriptions.
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  • The gene Jun-related antigen is referred to in FlyBase by the symbol Dmel\Jra (CG2275, FBgn0001291). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5983985..5986061. It has the cytological map location 46E4-46E5. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of antimicrobial humoral response; micropyle formation; JNK cascade; imaginal disc fusion, thorax closure; dorsal appendage formation; phagocytosis, engulfment. 27 alleles are reported. The phenotypes of these alleles are annotated with 21 unique terms, many of which group under: external compound sense organ; peripheral nervous system; nervous system; compound cell cluster organ; imaginal precursor; rhabdomere; primordium; commissure; cell projection; ommatidial precursor cluster; multi-cell-component structure; cell component. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Jun-related antigen is referred to in FlyBase by the symbol Dmel\Jra (CG2275, FBgn0001291). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5983985..5986061. It has the cytological map location 46E4-46E5. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of antimicrobial humoral response; micropyle formation; JNK cascade; imaginal disc fusion, thorax closure; dorsal appendage formation; phagocytosis, engulfment. 27 alleles are reported. The phenotypes of these alleles are annotated with 21 unique terms, many of which group under: external compound sense organ; peripheral nervous system; nervous system; compound cell cluster organ; imaginal precursor; rhabdomere; primordium; commissure; cell projection; ommatidial precursor cluster; multi-cell-component structure; cell component. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 289 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS][NAS]
    cytoplasm [IDA]
    Biological Process: dorsal closure [NAS][TAS]
    imaginal disc fusion, thorax closure [IMP]
    R7 cell fate commitment [TAS]
    dorsal appendage formation [IMP]
    regulation of transcription, DNA-dependent [IEA]
    JNK cascade [IGI][IMP][TAS]
    R3/R4 cell fate commitment [TAS]
    regulation of transcription [IEA]
    micropyle formation [IMP]
    negative regulation of antimicrobial humoral response [IGI][IMP]
    regulation of transcription from RNA polymerase II promoter [NAS]
    MAPKKK cascade [TAS]
    phagocytosis, engulfment [IMP]
    establishment of planar polarity [NAS]
    Molecular Function: transcription factor activity [IEA]
    protein binding [IPI]
    RNA polymerase II transcription factor activity [ISS]
    protein heterodimerization activity [ISS]
    specific RNA polymerase II transcription factor activity [NAS]
    protein dimerization activity [IEA]
    sequence-specific DNA binding [IEA]
    transcription factor binding [NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTPVSAAAN LSIQNAGSSG ATAIQIIPKT EPVGEEGPMS LDFQSPNLNT STPNPNKRPG  60
   61 SLDLNSKSAK NKRIFAPLVI NSPDLSSKTV NTPDLEKILL SNNLMQTPQP GKVFPTKAGP 120
  121 VTVEQLDFGR GFEEALHNLH TNSQAFPSAN SAANSAANNT TAAAMTAVNN GISGGTFTYT 180
  181 NMTEGFSVIK DEPVNQASSP TVNPIDMEAQ EKIKLERKRQ RNRVAASKCR KRKLERISKL 240
  241 EDRVKVLKGE NVDLASIVKN LKDHVAQLKQ QVMEHIAAGC TVPPNSTDQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..199] Pfam 96.356547 No description for PF03957.4 was found. No confident structure predictions are available.
    2 View Details [200..289] PSI-BLAST 14.39794 C-jun


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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