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Protein Overview: CG8728-PA

General Information:
Name(s) found: CG8728-PA / FBpp0087958 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG8728 (CG8728, FBgn0033235). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3824362..3826674. It has the cytological map location 43F3-43F4. Based on sequence similarity, it is predicted to have molecular function</span>: metalloendopeptidase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: protein processing. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 556 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [ISS]
    Biological Process: proteolysis [IEA]
    protein processing [ISS]
    Molecular Function: zinc ion binding [IEA]
    metalloendopeptidase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNGRSIGML KKLRHTWRTF PRLMATKVTS LGGDEVGSGT GIGQITGGVR TSDGPQKVNT  60
   61 PSKEIVTHLP PLTEPLPNLP EAVYAAPLAE SAITKVTTLP NGLRIASEPR YGQFCTVGLV 120
  121 IDSGPRYEVA YPSGVSHFLE KLAFNSTVNF PNKDAILKEL EKNGGICDCQ SSRDTLIYAA 180
  181 SIDSRAIDSV TRLLADVTLR PTLSDQEVSL ARRAVNFELE TLGMRPEQEP ILMDMIHAAA 240
  241 FRDNTLGLPK LCPLENLDHI NRNVLMNYLK YHHSPKRMVI AGVGVDHDEL VSHVQRYFVE 300
  301 DKAIWETEAL EDSGPKQVDT SIAQYTGGLV KEQCEIPIYA AAGLPELAHV ILGFEGCSHQ 360
  361 DKDFVPLCVL NIMMGGGGSF SAGGPGKGMY SRLYTKVLNR YHWMYSATAY NHAYGDCGLF 420
  421 CVHGSAPPQH MNDMVEVLTR EMMGMAAEPG REELMRSKIQ LQSMLLMNLE SRPVVFEDVG 480
  481 RQVLVTGQRK RPQHFIKEIE SVTAADIQRV AQRLLSSPPS VAARGDIHNL PEMSHITNAV 540
  541 SGSGRTGLGR RLSLFK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..92] deduced N/A No confident structure predictions are available.
    2 View Details [93..556] PSI-BLAST 76.69897 Mitochondrial processing peptidase (MPP) alpha chain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
    		•  10.0305725791312 bayes_pls_golite062009
  • ubiquinol-cytochrome-c reductase activity
    		•  10.0305725791312 bayes_pls_golite062009
  • metallopeptidase activity
    		•  7.31794755224524 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  7.31174048559335 bayes_pls_golite062009
  • peptidase activity
    		•  7.05972470989638 bayes_pls_golite062009
  • oxidoreductase activity, acting on diphenols and related substances as donors
    		•  6.64269017601856 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  6.57226784092621 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  4.17510847735476 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  4.03221088799464 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.89224384280888 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.48526983761385 bayes_pls_golite062009
  • endopeptidase activity
    		•  3.25021389096625 bayes_pls_golite062009
  • hydrolase activity
    		•  2.79262298779436 bayes_pls_golite062009
  • transporter activity
    		•  1.55442313420533 bayes_pls_golite062009
  • binding
    		•  1.51460850438647 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.40378628474509 bayes_pls_golite062009
  • catalytic activity
    		•  1.30647052031202 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.29599547747567 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.16717310870379 bayes_pls_golite062009
  • signal transducer activity
    		•  1.12122807250795 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.12122807250795 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.05022391589259 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.961854978876222 bayes_pls_golite062009
  • protein binding
    		•  0.236143103582996 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.11486391789734 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.077701103001661 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0688257218639591 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0662171656580391 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle