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Protein Overview: lok-PA

General Information:
Name(s) found: lok-PA / FBpp0080860 [FlyBase]
Description(s) found:
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  • gi|3204496|dbj|BAA28755.1| long form of nuclear kinase [Drosophila melanogaster] [NCBI NR]
  • gi|27923796|sp|O61267.1|LOK_DROME RecName: Full=Ovarian-specific serine/threonine-protein kinase Lok; AltName: Full=Protein loki; AltName: Full=dMNK [NCBI NR]
  • gi|22946886|gb|AAF53867.2| loki, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|17137306|ref|NP_477219.1| loki, isoform A [Drosophila melanogaster] [NCBI NR]
  • Ovarian-specific serine/threonine-protein kinase Lok OS=Drosophila melanogaster GN=lok PE=2 SV=1 [Swiss-Prot]
  • The gene loki is referred to in FlyBase by the symbol Dmel\lok (CG10895, FBgn0019686). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:20061477..20064381. It has the cytological map location 38B2. Based on sequence similarity, it is predicted to have molecular function</span>: protein kinase activity; protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: apoptosis; activation of caspase activity; cellular response to DNA damage stimulus; response to DNA damage stimulus; germ cell development; DNA damage response, signal transduction resulting in induction of apoptosis; DNA damage checkpoint. 11 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • >CG10895-PA translation from_gene[CG10895 lok FBgn0019686] seq_release:3 mol_weight=54262 cds_boundaries:(2L:20,039,954..20,042,049[+]) aa_length:476 transcript_info:[CG10895-RA seq_release:3] gene_info:[gene symbol:lok FBgn0019686 gene_boundaries:(2L: [hmr_yeast5_DM3-1_pombe.fasta]
  • (O61267) Ovarian-specific serine/threonine-protein kinase Lok (EC 2.7.1.37) (Loki protein) (dMNK) [DrosMelano7227.FASTAC.txt]
  • CG10895-PA, isoform A [Drosophila melanogaster]gi|17137306|ref|NP_477219.1| CG10895-PA [Drosophila melanogaster]gi|27923796|sp|O61267|LOK_DROME Ovarian-specific serine/threonine-protein kinase Lok (Loki protein) (dMNK)gi|3204496|dbj|BAA28755.1| long fo [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2L:join(20061877..20062063,20062148..20062305,20062545..20062653,20062734..20063171,20063378..20063612,20063672..20063975); ID=FBpp0080860; name=lok-PA; parent=FBgn0019686,FBtr0081328; dbxref=FlyBase:FBpp0080860,FlyBase_Annotation_IDs:CG [fly-100309-contam.fasta]
  • long form of nuclear kinase [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG10895-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Ovarian-specific serine/threonine-protein kinase Lok (Protein loki) (dMNK) [nr-271106-contam.fasta]
  • loki CG10895-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2L:join(20061877..20062063,20062148..20062305,20062545..20062653,20062734..20063171,20063378..20063612,20063672..20063975); ID=FBpp0080860; name=lok-PA; parent=FBgn0019686,FBtr0081328; dbxref=FlyBase:FBpp0080860,FlyBase_Annotation_IDs:CG10895-PA,GB_protein:AAF53867.2,REFSEQ:NP_477219,GB_protein:AAF53867; MD5=562088612e166ff1cae1664da75521bb; length=476; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2L:join(20061877..20062063,20062148..20062305,20062545..20062653,20062734..20063171,20063378..20063612,20063672..20063975); ID=FBpp0080860; name=lok-PA; parent=FBgn0019686,FBtr0081328; dbxref=FlyBase:FBpp0080860,FlyBase_Annotation_IDs:CG10895-PA,GB_protein:AAF53867.2,REFSEQ:NP_477219,GB_protein:AAF53867; MD5=562088612e166ff1cae1664da75521bb; length=476; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=2L:join(20061877..20062063,20062148..20062305,20062545..20062653,20062734..20063171,20063378..20063612,20063672..20063975); ID=FBpp0080860; name=lok-PA; parent=FBgn0019686,FBtr0081328; dbxref=FlyBase:FBpp0080860,FlyBase_Annotation_IDs:CG10895-PA,GB_protein:AAF53867.2,REFSEQ:NP_477219,GB_protein:AAF53867,FlyMine:FBpp0080860,modMine:FBpp0080860; MD5=562088612e166ff1cae1664da75521bb; length=476; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2L:join(20061877..20062063,20062148..20062305,20062545..20062653,20062734..20063171,20063378..20063612,20063672..20063975); ID=FBpp0080860; name=lok-PA; parent=FBgn0019686,FBtr0081328; dbxref=FlyBase:FBpp0080860,FlyBase_Annotation_IDs:CG10895-PA,GB_protein:AAF53867.2,REFSEQ:NP_477219,GB_protein:AAF53867,FlyMine:FBpp0080860,modMine:FBpp0080860; MD5=562088612e166ff1cae1664da75521bb; length=476; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2L:join(20061877..20062063,20062148..20062305,20062545..20062653,20062734..20063171,20063378..20063612,20063672..20063975); ID=FBpp0080860; name=lok-PA; parent=FBgn0019686,FBtr0081328; dbxref=FlyBase:FBpp0080860,FlyBase_Annotation_IDs:CG10895-PA,GB_protein:AAF53867.2,REFSEQ:NP_477219,GB_protein:AAF53867,FlyMine:FBpp0080860,modMine:FBpp0080860; MD5=562088612e166ff1cae1664da75521bb; length=476; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0080860 type=protein; loc=2L:join(20061877..20062063,20062148..20062305,20062545..20062653,20062734..20063171,20063378..20063612,20063672..20063975); ID=FBpp0080860; name=lok-PA; parent=FBgn0019686,FBtr0081328; dbxref=FlyBase:FBpp0080860,FlyBase_Annotation_IDs:CG10895-PA,GB_protein:AAF53867.2,REFSEQ:NP_477219,GB_protein:AAF53867,FlyMine:FBpp0080860,modMine:FBpp0080860; MD5=562088612e166ff1cae1664da75521bb; length=476; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2L:join(20061877..20062063,20062148..20062305,20062545..20062653,20062734..20063171,20063378..20063612,20063672..20063975); ID=FBpp0080860; name=lok-PA; parent=FBgn0019686,FBtr0081328; dbxref=FlyBase:FBpp0080860,FlyBase_Annotation_IDs:CG10895-PA,GB_protein:AAF53867.2,REFSEQ:NP_477219,GB_protein:AAF53867,UniProt/Swiss-Prot:O61267,FlyMine:FBpp0080860,modMine:FBpp0080860; MD5=562088612e166ff1cae1664da75521bb; length=476; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 476 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cytoplasm [NAS]
    Biological Process: germ cell development [IEP]
    DNA damage checkpoint [IMP]
    cell cycle checkpoint [ISS][TAS]
    apoptosis [IMP]
    DNA damage response, signal transduction resulting in induction of apoptosis [IMP]
    activation of caspase activity [IMP]
    protein amino acid phosphorylation [ISS][NAS]
    response to DNA damage stimulus [IMP]
    Molecular Function: ATP binding [IEA]
    protein kinase activity [ISS]
    protein serine/threonine kinase activity [IEA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARDTQGTQG TQSQASNIWT QVESQPMEKI VWGRLYGKNI KIKSLGTSSK YRIIYTHSSF  60
   61 SVDLNNDEFT AGRGEANDLI LTLNDLPEKI LTRISKVHFI IKRANCELTN PVYIQDLSRN 120
  121 GTFVNNEKIG TNRMRILKND DVISLSHPTY KAFVFKDLSP NESIGLPEEI NKTYYVNRKL 180
  181 GSGAYGLVRL VYDTRTCQQF AMKIVKKNML SGARPSTNFS DPDRVLNEAK IMKNLSHPCV 240
  241 VRMHDIVDKP DSVYMVLEFM RGGDLLNRII SNKLLSEDIS KLYFYQMCHA VKYLHDRGIT 300
  301 HRDLKPDNVL LETNDEETLL KVSDFGLSKF VQKDSVMRTL CGTPLYVAPE VLITGGREAY 360
  361 TKKVDIWSLG VVLFTCLSGT LPFSDEYGTP AAQQIKKGRF AYGHPSWKSV SQRAKLLINQ 420
  421 MLIVDPERRP SIDDVLQSSW LRDAPMLQKA KRLMKLDGME IEEENFLEPP TKRSRR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle