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Protein Overview: lwr-PA, lwr-PB, ...

General Information:
Name(s) found: FBpp0301732 [FlyBase]
FBpp0301731 [FlyBase]
lwr-PB / FBpp0077742 [FlyBase]
lwr-PA / FBpp0077741 [FlyBase]
Description(s) found:
Found 61 descriptions.
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  • type=protein; loc=2L:complement(541768..542247); ID=FBpp0301732; name=lwr-PD; parent=FBgn0010602,FBtr0310029; dbxref=FlyBase:FBpp0301732,FlyBase_Annotation_IDs:CG3018-PD,REFSEQ:NP_001259834,GB_protein:AGB92371; MD5=fbec2ef2b9d05035e50652c568cdb08e; length=159; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=2L:complement(541768..542247); ID=FBpp0301731; name=lwr-PC; parent=FBgn0010602,FBtr0310028; dbxref=FlyBase:FBpp0301731,FlyBase_Annotation_IDs:CG3018-PC,REFSEQ:NP_001259833,GB_protein:AGB92370; MD5=fbec2ef2b9d05035e50652c568cdb08e; length=159; release=r5.56; species=Dmel; [FlyBase]
  • The gene lesswright is referred to in FlyBase by the symbol Dmel\lwr (CG3018, FBgn0010602). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:541235..542572. It has the cytological map location 21E2. There is experimental evidence that it has the molecular function</span>: protein binding; SUMO ligase activity. There is experimental evidence that it is involved in the biological process</span>: female meiosis chromosome segregation; female meiosis; humoral immune response; negative regulation of hemocyte proliferation; negative regulation of Toll signaling pathway; hemocyte proliferation; zygotic determination of dorsal/ventral axis; protein import into nucleus; negative regulation of lamellocyte differentiation; protein modification process. 25 alleles are reported. The phenotypes of these alleles are annotated with: leg; eye; embryonic head; adult head; embryonic epidermis; wing; embryonic thoracic segment; crystal cell; embryonic abdominal segment. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene lesswright is referred to in FlyBase by the symbol Dmel\lwr (CG3018, FBgn0010602). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:541235..542572. It has the cytological map location 21E2. There is experimental evidence that it has the molecular function</span>: protein binding; SUMO ligase activity. There is experimental evidence that it is involved in the biological process</span>: female meiosis chromosome segregation; female meiosis; humoral immune response; negative regulation of hemocyte proliferation; negative regulation of Toll signaling pathway; hemocyte proliferation; zygotic determination of dorsal/ventral axis; protein import into nucleus; negative regulation of lamellocyte differentiation; protein modification process. 25 alleles are reported. The phenotypes of these alleles are annotated with: leg; eye; embryonic head; adult head; embryonic epidermis; wing; embryonic thoracic segment; crystal cell; embryonic abdominal segment. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 159 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    condensed nuclear chromosome, centromeric region [IDA]
    outer kinetochore of condensed chromosome [IDA]
    Biological Process: regulation of protein metabolic process [IEA]
    hemocyte proliferation [IMP]
    zygotic specification of dorsal/ventral axis [IGI]
    female meiosis [IGI]
    protein import into nucleus [IMP][IPI]
    humoral immune response [IMP]
    protein modification process [IGI][IPI]
    negative regulation of hemocyte proliferation [IMP]
    negative regulation of Toll signaling pathway [IMP]
    female meiosis chromosome segregation [IGI]
    post-translational protein modification [IEA]
    negative regulation of lamellocyte differentiation [IMP]
    Molecular Function: protein binding [IPI]
    SUMO ligase activity [IGI][IPI][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGIAITRLG EERKAWRKDH PFGFVARPAK NPDGTLNLMI WECAIPGKKS TPWEGGLYKL  60
   61 RMIFKDDYPT SPPKCKFEPP LFHPNVYPSG TVCLSLLDEE KDWRPAITIK QILLGIQDLL 120
  121 NEPNIKDPAQ AEAYTIYCQN RLEYEKRVRA QARAMAATE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..159] PSI-BLAST 49.0 HUMAN UBC9

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  11.3486134076304 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  11.2964721480824 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  10.2401422444624 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  8.93602533934698 bayes_pls_golite062009
  • HLH domain binding
    		•  8.10904818707269 bayes_pls_golite062009
  • ligase activity
    		•  5.89730943108033 bayes_pls_golite062009
  • SUMO ligase activity
    		•  3.88357560284404 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.21355731489173 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.13970605403492 bayes_pls_golite062009
  • DNA binding
    		•  1.95596447916631 bayes_pls_golite062009
  • protein binding
    		•  1.77678273247394 bayes_pls_golite062009
  • binding
    		•  1.75350658654805 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.5236035191291 bayes_pls_golite062009
  • transcription activator activity
    		•  1.19240180311941 bayes_pls_golite062009
  • catalytic activity
    		•  0.891402822028799 bayes_pls_golite062009
  • NEDD8 ligase activity
    		•  0.715654744941217 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.58835335751383 bayes_pls_golite062009
  • kinase activity
    		•  0.519703305315987 bayes_pls_golite062009
  • protein kinase activity
    		•  0.443948654247666 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.373779304908933 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.182854082413338 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.122859425935324 bayes_pls_golite062009
  • transferase activity
    		•  0.0984525836903841 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0104967529560147 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle