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Protein Overview: gi|27665448, gi|...

General Information:
Name(s) found: gi|27665448 [NCBI NR]
gi|197245751 [NCBI NR]
gi|187469503 [NCBI NR]
gi|157818381 [NCBI NR]
gi|149031883 [NCBI NR]
gi|149031882 [NCBI NR]
gi|109482999 [NCBI NR]
Description(s) found:
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  • gi|27665448|ref|XP_217062.1| PREDICTED: similar to Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha) [Rattus norvegicus] [NCBI NR]
  • gi|197245751|gb|AAI68739.1| Chromobox homolog 5 (HP1 alpha homolog, Drosophila) [Rattus norvegicus] [NCBI NR]
  • gi|187469503|gb|AAI66908.1| Cbx5 protein [Rattus norvegicus] [NCBI NR]
  • gi|157818381|ref|NP_001100267.1| chromobox homolog 5 (HP1 alpha homolog, Drosophila) [Rattus norvegicus] [NCBI NR]
  • gi|149031883|gb|EDL86795.1| chromobox homolog 5 (Drosophila HP1a) (predicted), isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|149031882|gb|EDL86794.1| chromobox homolog 5 (Drosophila HP1a) (predicted), isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|109482999|ref|XP_001069676.1| PREDICTED: similar to Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha) [Rattus norvegicus] [NCBI NR]
  • Ensembl_locations(Chr-bp):7-132661446;7-132661446;7-132661446 [hmr_yeast5_DM3-1_pombe.fasta]
  • similar to HP1 alpha protein [HMR_022704-rand.fasta]
  • similar to HP1 alpha protein [Rattus norvegicus]gi|13435681|gb|AAH04707.1| Cbx5 protein [Mus musculus]gi|6671694|ref|NP_031652.1| chromobox homolog 5 (Drosophila HP1a) [Mus musculus]gi|8895495|gb|AAF80993.1| heterochromatin protein 1 alpha [Mus musculu [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 PREDICTED: similar to HP1 alpha protein [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Tax_Id=10116 Similar to HP1 alpha protein [EBI-IPI_rat_3.05_04-04-2005_origrev.fasta]
  • Cbx5 protein [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • chromobox homolog 5 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • chromobox homolog 5 (Drosophila HP1a) (predicted), isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 SIMILAR TO HP1 ALPHA PROTEIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • chromobox homolog 5 (HP1 alpha homolog, Drosophila) [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta]
  • PREDICTED: similar to Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha) [Rattus norvegicus] [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Cbx5 Cbx5 protein [rat-ipi-250309-contam.fasta]
  • Cbx5 protein OS=Rattus norvegicus GN=Cbx5 [011711_HMR.fasta]
  • Cbx5 protein OS=Rattus norvegicus GN=Cbx5 PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
  • Cbx5 protein OS=Rattus norvegicus GN=Cbx5 PE=1 SV=1 [RAT.fasta.20160308]
    • Organism: Rattus norvegicus
    Length: 191 amino acids

    Gene Ontology:
    Cellular Component: heterochromatin [UNKNOWN]
    nucleus [UNKNOWN][IEA]
    PML body [UNKNOWN][IEA]
    cytoplasm [UNKNOWN][IEA]
    transcriptional repressor complex [IEA]
    histone methyltransferase complex [IEA]
    chromocenter [UNKNOWN][IEA]
    histone deacetylase complex [IEA]
    kinetochore [UNKNOWN][IEA]
    nucleolus [UNKNOWN][IEA]
    chromatin [IEA]
    nuclear heterochromatin [UNKNOWN][IEA]
    Biological Process: negative regulation of transcription, DNA-dependent [UNKNOWN][IEA]
    negative regulation of transcription [UNKNOWN]
    chromatin assembly or disassembly [IEA]
    Molecular Function: protein binding [UNKNOWN]
    transcription repressor binding [IEA]
    methylated histone residue binding [UNKNOWN]
    chromatin binding [UNKNOWN][IEA]
    transcription repressor activity [UNKNOWN]
    general transcriptional repressor activity [UNKNOWN][IEA]
    protein binding, bridging [IEA]
    enzyme binding [UNKNOWN][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKKTKRTAD SSSSEDEEEY VVEKVLDRRM VKGQVEYLLK WKGFSEEHNT WEPEKNLDCP  60
   61 ELISEFMKKY KKMKEGENNK PREKSEGNKR KSSFSNSADD IKSKKKREQS NDIARGFERG 120
  121 LEPEKIIGAT DSCGDLMFLM KWKDTDEADL VLAKEANVKC PQIVIAFYEE RLTWHAYPED 180
  181 AENKEKESAK S

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..102] PSI-BLAST 13.045757 No description for 2d9uA was found.
    2 View Details [103..191] PSI-BLAST 19.522879 HP1 chromo shadow domain in complex with PXVXL motif of CAF-1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription repressor activity
    		•  4.08500855631983 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.64390820819794 bayes_pls_golite062009
  • methylated histone residue binding
    		•  3.42338304360938 bayes_pls_golite062009
  • chromatin binding
    		•  3.1924157640698 bayes_pls_golite062009
  • binding
    		•  3.06758476214113 bayes_pls_golite062009
  • protein binding
    		•  2.66728689880621 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.19167058827256 bayes_pls_golite062009
  • DNA binding
    		•  2.05514577638135 bayes_pls_golite062009
  • histone binding
    		•  2.00388175060339 bayes_pls_golite062009
  • transcription activator activity
    		•  1.46529895769882 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.10020047862576 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.998957812785999 bayes_pls_golite062009
  • general transcriptional repressor activity
    		•  0.75184432495983 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.726970683178132 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.494788451379878 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.294457188332415 bayes_pls_golite062009
  • catalytic activity
    		•  0.14067200158938 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle