Protein Overview: AA1R_RAT

General Information:
Name(s) found:	AA1R_RAT [Swiss-Prot]
Description(s) found: Found 24 descriptions. SHOW ALL	Adenosine receptor A1 OS=Rattus norvegicus GN=Adora1 PE=2 SV=2 [Swiss-Prot]
Organism:	Rattus norvegicus
Length:	326 amino acids
Gene Ontology:
Cellular Component:	presynaptic membrane [IDA] postsynaptic density [IDA] endoplasmic reticulum [IMP] neuronal cell body [IDA] plasma membrane [IDA] dendrite [IDA] presynaptic active zone [IDA] terminal button [IDA] postsynaptic membrane [IDA] integral to membrane [IEA] endomembrane system [IDA] asymmetric synapse [IDA] axolemma [IDA] basolateral plasma membrane [IDA]
Biological Process:	inhibition of adenylate cyclase activity by G-protein signaling pathway [IMP] negative regulation of vasodilation [IDA] regulation of glomerular filtration [UNKNOWN] negative regulation of cell proliferation [IDA] relaxation of vascular smooth muscle [IMP] positive regulation of potassium ion transport [IDA] regulation of respiratory gaseous exchange by neurological system process [IMP] positive regulation of epidermal growth factor receptor activity [IMP] [NOT]regulation of vasodilation [IDA] negative regulation of heart contraction [IMP] activation of MAPKK activity [IDA] negative regulation of synaptic transmission, GABAergic [IDA][IMP] negative regulation of neurotrophin production [IMP] cognition [IMP] regulation of synaptic plasticity [IMP] negative regulation of synaptic transmission, glutamatergic [IDA] positive regulation of nucleoside transport [IDA] natriuresis [IMP] negative regulation of lipid catabolic process [IDA] regulation of excitatory postsynaptic membrane potential [UNKNOWN][IMP] G-protein coupled receptor protein signaling pathway [IDA] signal transduction [IEA] negative regulation of inflammatory response [UNKNOWN][IEA] negative regulation of glutamate secretion [IDA] negative regulation of circadian sleep/wake cycle, sleep [IDA] negative regulation of circadian sleep/wake cycle, non-REM sleep [IMP] positive regulation of peptide secretion [IMP] protein targeting to membrane [IMP] positive regulation of blood pressure [IDA] negative regulation of hormone secretion [IMP] negative regulation of leukocyte migration [UNKNOWN][IEA] negative regulation of apoptosis [IDA] temperature homeostasis [IMP] lipid catabolic process [IMP] positive regulation of protein amino acid dephosphorylation [IDA] negative regulation of mucus secretion [UNKNOWN][IEA] detection of temperature stimulus involved in sensory perception of pain [IMP] regulation of cardiac muscle contraction [IMP] negative regulation of cardiac muscle contraction [IMP]
Molecular Function:	purine nucleoside binding [IPI] G-protein coupled receptor activity [IEA] protein heterodimerization activity [IPI] heterotrimeric G-protein binding [IDA] G-protein beta/gamma-subunit binding [IDA] adenosine receptor activity, G-protein coupled [IDA][TAS] receptor activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPYISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA  60
   61 LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA IAVDRYLRVK IPLRYKTVVT 120
  121 QRRAAVAIAG CWILSLVVGL TPMFGWNNLS VVEQDWRANG SVGEPVIKCE FEKVISMEYM 180
  181 VYFNFFVWVL PPLLLMVLIY LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL 240
  241 FLFALSWLPL HILNCITLFC PTCQKPSILI YIAIFLTHGN SAMNPIVYAF RIHKFRVTFL 300
  301 KIWNDHFRCQ PKPPIDEDLP EEKAED

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: AA1R_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: