YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. Any process that modulates the size of blood vessels. Any process that stops, prevents or reduces the frequency, rate or extent of muscle contraction. Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction. A process whereby the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain. An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure. Any process that modulates the frequency, rate or extent of smooth muscle contraction. A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. A process whereby the extent of vascular smooth muscle contraction is reduced. Vascular smooth muscle relaxation is mediated via a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: relaxation of vascular smooth muscle
Acc: GO:0060087
Aspect: Biological Process
Desc: A process whereby the extent of vascular smooth muscle contraction is reduced. Vascular smooth muscle relaxation is mediated via a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity.
Synonyms:
  • vascular smooth muscle relaxation
Proteins in PDR annotated with:
   This term: 15 [Search]
   Term or descendants: 15 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0060087 - relaxation of vascular smooth muscle (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle