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Protein Overview: NKX25_RAT

General Information:
Name(s) found: NKX25_RAT [Swiss-Prot]
Description(s) found:
Found 16 descriptions.
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  • Homeobox protein Nkx-2.5 OS=Rattus norvegicus GN=Nkx2-5 PE=2 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 318 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IDA]
    transcription factor complex [UNKNOWN][IEA]
    cytoplasm [IEA]
    Biological Process: positive regulation of calcium ion transport via voltage-gated calcium channel activity [IEA]
    positive regulation of survival gene product expression [UNKNOWN][IEA]
    tongue development [UNKNOWN][IEA]
    cardiac muscle contraction [UNKNOWN]
    cardiac ventricle formation [UNKNOWN][IEA]
    atrioventricular node cell fate commitment [UNKNOWN][IEA]
    heart morphogenesis [UNKNOWN]
    positive regulation of gene-specific transcription [UNKNOWN]
    cardiac ventricle morphogenesis [UNKNOWN]
    positive regulation of transcription via serum response element binding [IEA]
    positive regulation of transcription, DNA-dependent [UNKNOWN]
    atrioventricular node cell development [UNKNOWN][IEA]
    heart looping [UNKNOWN][IEA]
    ventricular cardiac myofibril development [UNKNOWN][IEA]
    cardiac muscle cell differentiation [UNKNOWN][IEA]
    cardiac muscle tissue morphogenesis [UNKNOWN][IEA]
    proepicardium development [UNKNOWN][IEA]
    pharyngeal system development [UNKNOWN][IEA]
    ventricular trabecular myocardium morphogenesis [UNKNOWN][IEA]
    positive regulation of cardioblast differentiation [UNKNOWN][IEA]
    response to estradiol stimulus [IEP]
    atrial cardiac muscle cell development [UNKNOWN][IEA]
    ventricular cardiac muscle cell development [UNKNOWN]
    negative regulation of cardiac muscle cell apoptosis [UNKNOWN][IEA]
    multicellular organismal development [IEA]
    positive regulation of transcription initiation from RNA polymerase II promoter [IEA]
    hemopoiesis [UNKNOWN][IEA]
    positive regulation of cell proliferation [UNKNOWN][IEA]
    outflow tract morphogenesis [UNKNOWN][IEA]
    pulmonary myocardium development [UNKNOWN][IEA]
    positive regulation of neuron differentiation [UNKNOWN][IEA]
    spleen development [UNKNOWN][IEA]
    vasculogenesis [UNKNOWN][IEA]
    positive regulation of heart contraction [IEA]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    cardiac muscle tissue development [UNKNOWN]
    apoptosis involved in heart morphogenesis [UNKNOWN][IEA]
    heart trabecula formation [UNKNOWN][IEA]
    adult heart development [UNKNOWN][IEA]
    negative regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    heart development [UNKNOWN]
    negative regulation of myotube differentiation [UNKNOWN][IEA]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN]
    negative regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN]
    embryonic heart tube left/right pattern formation [UNKNOWN][IEA]
    cardiac conduction system development [UNKNOWN][IEA]
    regulation of transcription, DNA-dependent [IEA]
    septum secundum development [UNKNOWN]
    embryonic heart tube development [UNKNOWN]
    bundle of His development [UNKNOWN][IEA]
    ventricular septum morphogenesis [UNKNOWN][IEA]
    cardiac Purkinje fiber cell differentiation [UNKNOWN][IEA]
    atrial septum morphogenesis [UNKNOWN][IEA]
    regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    thyroid gland development [UNKNOWN][IEA]
    negative regulation of apoptosis [UNKNOWN][IEA]
    positive regulation of sodium ion transport [IEA]
    cell differentiation [UNKNOWN]
    regulation of cardiac muscle contraction [IEA]
    Molecular Function: DNA binding [UNKNOWN]
    transcription factor activity [UNKNOWN][IDA]
    protein binding [UNKNOWN][IPI]
    protein homodimerization activity [IDA]
    serum response element binding [IEA]
    protein heterodimerization activity [UNKNOWN][IEA]
    sequence-specific DNA binding [UNKNOWN][IDA]
    chromatin binding [UNKNOWN][IEA]
    transcription factor binding [UNKNOWN][IEA]
    promoter binding [UNKNOWN]
    transcription activator activity [UNKNOWN][IEA]
    transcription repressor activity [UNKNOWN][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFPSPALTHT PFSVKDILNL EQQQRSLAAG DLSARLEATL APASCMLAAF KPDGYSGPEA  60
   61 AAPGLAELRA ELGPAPSPPK CSPAFPTAPT FYPRAYGDPD PAKDPRADKK ELCALQKAVE 120
  121 LDKAETDGAE RRRPRRRRKP RVLFSQAQVY ELERRFKQQR YLSPAERDQL ASVLKLTSTQ 180
  181 VKIWFQNRRY KCKRQRQDQT LELLGPPPPP ARRIAVPVLV RDGKPCLGDS AAYAPAYGLG 240
  241 LNAYGYNAYP YPGYGGAACS PAYSCAAYPA APPAAHAPAA SANSNFVNFG VGDLNTVQSP 300
  301 GMPQGNSGVS TLHGIRAW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle