Protein Overview: ADA10_RAT

General Information:
Name(s) found:	ADA10_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|683663\|emb\|CAA88359.1\| disintegrin-metalloprotease pre-pro-protein [Rattus norvegicus] [NCBI NR] gi\|37096570\|sp\|Q10743.1\|ADA10_RAT RecName: Full=Disintegrin and metalloproteinase domain-containing protein 10; Short=ADAM 10; AltName: Full=Mammalian disintegrin-metalloprotease; AltName: Full=Kuzbanian protein homolog; AltName: CD_antigen=CD156c; Flags: [NCBI NR] pir\|\|S52477 disintegrin (EC 3.4.24.-) precursor - rat (fragment) [NCBI NR] Disintegrin and metalloproteinase domain-containing protein 10 (Fragment) OS=Rattus norvegicus GN=Adam10 PE=2 SV=1 [Swiss-Prot] (Q10743) ADAM 10 precursor (EC 3.4.24.81) (A disintegrin and metalloproteinase domain 10) (Mammalian disintegrin-metalloprotease) (Kuzbanian protein homolog) (Fragment) [Swiss-Prot] Ensembl_locations(Chr-bp):8-73467346 ADAM 10 precursor [hmr_yeast5_DM3-1_pombe.fasta] disintegrin-metalloprotease pre-pro-protein [Rattus norvegicus]gi\|1083644\|pir\|\|S52477 disintegrin (EC 3.4.24.-) precursor - rat (fragment)gi\|37096570\|sp\|Q10743\|AD10_RAT ADAM 10 precursor (A disintegrin and metalloproteinase domain 10) (Mammalian disinte [nrdb_11152004_Chlamydomonas] ADAM 10 precursor (A disintegrin and metalloproteinase domain 10) (Mammalian disintegrin-metalloprotease) (Kuzbanian protein homolog) (CD156c antigen) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] disintegrin-metalloprotease pre-pro-protein [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 ADAM 10 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] ADAM 10 precursor (A disintegrin and metalloproteinase domain 10) (Mammalian disintegrin-metalloprotease) (Kuzbanian protein homolog) [nr-271106-contam.fasta] Disintegrin and metalloproteinase domain-containing protein 10 (Fragment) OS=Rattus norvegicus GN=Adam10 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	544 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [IDA] nucleus [ISS] postsynaptic density [UNKNOWN] trans-Golgi network [IDA] cytoplasm [ISS] membrane [IEA] integral to membrane [IEA] Golgi apparatus [UNKNOWN][ISS] Golgi-associated vesicle [UNKNOWN][ISS] cell surface [UNKNOWN][ISS]
Biological Process:	neuroprotection [IEP] negative regulation of cell adhesion [UNKNOWN][ISS] positive regulation of cell proliferation [UNKNOWN] protein amino acid phosphorylation [ISS] monocyte activation [UNKNOWN] positive regulation of cell growth [UNKNOWN] Notch signaling pathway [ISS] membrane protein ectodomain proteolysis [UNKNOWN][ISS] PMA-inducible membrane protein ectodomain proteolysis [UNKNOWN] in utero embryonic development [ISS] constitutive protein ectodomain proteolysis [UNKNOWN] regulation of osteoclast differentiation [NAS] proteolysis [IEA] positive regulation of T cell chemotaxis [UNKNOWN] positive regulation of cell migration [UNKNOWN] response to tumor necrosis factor [UNKNOWN]
Molecular Function:	protein kinase binding [ISS] zinc ion binding [IEA] protein binding [UNKNOWN] protein homodimerization activity [ISS] metal ion binding [IEA] endopeptidase activity [UNKNOWN] peptidase activity [IEA] SH3 domain binding [UNKNOWN][IEA] metalloendopeptidase activity [IDA][IEA] metallopeptidase activity [UNKNOWN][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPELLRKKRT TLPERNTCQL YIQTDHLFFK SYGTREAVIA QISSHVKAID AIYQTTDFSG  60
   61 IRNISFMVKR IRINTTSDEK DPTNPFRFPN IGVEKFLELN SEQNHDDYCL AYVFTDRDFD 120
  121 DGVLGLAWVG APSGSSGGIC EKSKLYSDGK KKSLNTGIIT VQNYGSHVPP KVSHITFAHE 180
  181 VGHNFGSPHD SGTECTPGES KNLGQKENGN YIMYARATSG DKLNNNKFSL CSIRNISQVL 240
  241 EKKRNNCFVE SGQPICGNGM VEQGEECDCG YSDQCKDECC FDANQPEGKK CKLKPGKQCS 300
  301 PSQGPCCTAQ CAFKSKSEKC RDDSDCAKEG ICNGFTALCP ASDPKPNFTD CNRHTQVCIN 360
  361 GQCAGSICEK YDLEECTCAS SDGKDDKELC HVCCMKKMAP STCASTGSLQ WNKQFTGRTI 420
  421 TLQPGSPCND FRGYCDVFMR CRLVDADGPL ARLKKAIFSP QLYENIAEWI VAHWWAVLLM 480
  481 GIALIMLMAG FIKICSVHTP SSNPKLPPPK PLPGTLKRRR PPQPIQQPQR QRPRESYQMG 540
  541 HMRR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: ADA10_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: