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Protein Overview: A4_RAT

General Information:
Name(s) found: A4_RAT [Swiss-Prot]
Description(s) found:
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  • gi|27436861|ref|NP_062161.1| amyloid beta (A4) precursor protein [Rattus norvegicus] [NCBI NR]
  • gi|22038049|gb|AAM90259.1|AF513015_1 APP770 [Rattus norvegicus] [NCBI NR]
  • gi|149059743|gb|EDM10626.1| amyloid beta (A4) precursor protein, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|112930|sp|P08592.2|A4_RAT RecName: Full=Amyloid beta A4 protein; AltName: Full=Alzheimer disease amyloid A4 protein homolog; AltName: Full=ABPP; Short=APP; AltName: Full=Amyloidogenic glycoprotein; Short=AG; Contains: RecName: Full=Soluble APP-alpha; S [NCBI NR]
  • Amyloid beta A4 protein OS=Rattus norvegicus GN=App PE=1 SV=2 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):11-75464997 Splice isoform APP770 of P08592 [hmr_yeast5_DM3-1_pombe.fasta]
  • amyloid beta (A4) precursor protein [HMR_022704-rand.fasta]
  • amyloid beta (A4) precursor protein [Rattus norvegicus]gi|22038049|gb|AAM90259.1| APP770 [Rattus norvegicus]gi|112930|sp|P08592|A4_RAT Amyloid beta A4 protein precursor (APP) (Alzheimer's disease amyloid protein homolog) (Amyloidogenic glycoprotein) (AG [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Splice Isoform APP770 of Amyloid beta A4 protein precursor (Fragment) [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Tax_Id=10116 Splice Isoform APP770 of Amyloid beta A4 protein precursor [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta]
  • Amyloid beta A4 protein precursor (Alzheimer disease amyloid A4 protein homolog) (ABPP) (APP) (Amyloidogenic glycoprotein) (AG) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42 (Beta-APP42); Beta-amyl [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • amyloid beta (A4) precursor protein [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • amyloid beta (A4) precursor protein, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • unnamed protein product [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • APP770 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 SPLICE ISOFORM 1 OF AMYLOID BETA A4 PROTEIN PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein homolog) (Amyloidogenic glycoprotein) (AG) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=App Isoform APP770 of Amyloid beta A4 protein (Fragment) [rat-ipi-250309-contam.fasta]
  • Isoform APP770 of Amyloid beta A4 protein OS=Rattus norvegicus GN=App [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 770 amino acids

    Gene Ontology:
    Cellular Component: platelet alpha granule lumen [UNKNOWN]
    ciliary rootlet [UNKNOWN][IEA]
    synaptosome [IDA]
    Golgi apparatus [UNKNOWN][IDA][ISS]
    synapse [UNKNOWN]
    extracellular region [UNKNOWN]
    neuron projection [UNKNOWN]
    plasma membrane [IEA]
    cell surface [UNKNOWN][IEA]
    membrane fraction [UNKNOWN]
    spindle midzone [UNKNOWN][IEA]
    perinuclear region of cytoplasm [UNKNOWN][IEA]
    apical part of cell [UNKNOWN][IEA]
    cytoplasm [UNKNOWN][ISS]
    coated pit [IEA]
    dendritic shaft [UNKNOWN][IEA]
    membrane [UNKNOWN]
    dendritic spine [UNKNOWN][IEA]
    integral to membrane [UNKNOWN][IEA][ISS]
    cytoplasmic vesicle [UNKNOWN][IEA]
    neuromuscular junction [UNKNOWN][IEA]
    axon [UNKNOWN][ISS]
    Biological Process: regulation of multicellular organism growth [UNKNOWN][ISS]
    regulation of epidermal growth factor receptor activity [UNKNOWN][ISS]
    [NOT]axon cargo transport [UNKNOWN][ISS]
    cell adhesion [IEA]
    adult locomotory behavior [UNKNOWN][ISS]
    visual learning [UNKNOWN][ISS]
    protein amino acid phosphorylation [UNKNOWN][ISS]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    regulation of translation [UNKNOWN][ISS]
    smooth endoplasmic reticulum calcium ion homeostasis [UNKNOWN][IEA]
    cellular copper ion homeostasis [UNKNOWN][ISS]
    locomotory behavior [UNKNOWN][ISS]
    forebrain development [UNKNOWN][IEA]
    synaptic growth at neuromuscular junction [UNKNOWN][IEA]
    G2 phase of mitotic cell cycle [UNKNOWN][ISS]
    induction of apoptosis [IDA]
    axonogenesis [UNKNOWN][ISS]
    suckling behavior [UNKNOWN][IEA]
    axon midline choice point recognition [UNKNOWN][ISS]
    ionotropic glutamate receptor signaling pathway [UNKNOWN][ISS]
    neuron apoptosis [UNKNOWN][IEA]
    dendrite development [UNKNOWN][ISS]
    neuron projection development [UNKNOWN][ISS]
    collateral sprouting in the absence of injury [UNKNOWN][ISS]
    endocytosis [UNKNOWN][ISS]
    mRNA polyadenylation [UNKNOWN][ISS]
    positive regulation of mitotic cell cycle [UNKNOWN][ISS]
    mating behavior [UNKNOWN][ISS]
    Notch signaling pathway [IEA]
    extracellular matrix organization [UNKNOWN][ISS]
    regulation of synapse structure and activity [UNKNOWN][ISS]
    neuron remodeling [UNKNOWN][ISS]
    neuromuscular process controlling balance [UNKNOWN][IEA]
    Molecular Function: DNA binding [UNKNOWN][ISS]
    peptidase inhibitor activity [IEA]
    serine-type endopeptidase inhibitor activity [UNKNOWN][IEA]
    peptidase activator activity [IDA]
    identical protein binding [UNKNOWN][IEA]
    protein binding [UNKNOWN][IPI]
    metal ion binding [IEA]
    acetylcholine receptor binding [UNKNOWN][IEA]
    heparin binding [IEA]
    binding [IEA]
    receptor binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG KWESDPSGTK  60
   61 TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHTH IVIPYRCLVG 120
  121 EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR 180
  181 GVEFVCCPLA EESDSIDSAD AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE 240
  241 EAEDDEDVED GDEVEEEAEE PYEEATERTT SIATTTTTTT ESVEEVVREV CSEQAETGPC 300
  301 RAMISRWYFD VTEGKCAPFF YGGCGGNRNN FDTEEYCMAV CGSVSSQSLL KTTSEPLPQD 360
  361 PVKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM REWEEAERQA 420
  421 KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR LALENYITAL 480
  481 QAVPPRPHHV FNMLKKYVRA EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER 540
  541 MNQSLSLLYN VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET 600
  601 KTTVELLPVN GEFSLDDLQP WHPFGVDSVP ANTENEVEPV DARPAADRGL TTRPGSGLTN 660
  661 IKTEEISEVK MDAEFGHDSG FEVRHQKLVF FAEDVGSNKG AIIGLMVGGV VIATVIVITL 720
  721 VMLKKKQYTS IHHGVVEVDA AVTPEERHLS KMQQNGYENP TYKFFEQMQN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle