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Protein Overview: NKX21_RAT

General Information:
Name(s) found: NKX21_RAT [Swiss-Prot]
Description(s) found:
Found 14 descriptions.
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  • Homeobox protein Nkx-2.1 OS=Rattus norvegicus GN=Nkx2-1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 372 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IMP][TAS]
    transcription factor complex [UNKNOWN][IEA]
    soluble fraction [UNKNOWN][IEA]
    nucleoplasm [IDA]
    Biological Process: branching involved in lung morphogenesis [UNKNOWN][IEA]
    hyperosmotic salinity response [IDA]
    Clara cell differentiation [UNKNOWN][IEA]
    telencephalon development [UNKNOWN]
    forebrain neuron differentiation [UNKNOWN]
    endoderm development [UNKNOWN][IEA]
    globus pallidus development [UNKNOWN][IEA]
    axon guidance [UNKNOWN][IEA]
    feeding behavior [IMP]
    forebrain dorsal/ventral pattern formation [UNKNOWN][IEA]
    telencephalon cell migration [UNKNOWN]
    forebrain neuron fate commitment [UNKNOWN][IEA]
    menarche [UNKNOWN][IEA]
    phospholipid metabolic process [UNKNOWN][IEA]
    cerebral cortex GABAergic interneuron differentiation [UNKNOWN][IEA]
    regulation of transcription [IDA]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IDA]
    cerebral cortex cell migration [UNKNOWN][IEA]
    cerebral cortex neuron differentiation [UNKNOWN]
    negative regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    regulation of blood volume by renin-angiotensin [IDA]
    response to ethanol [IEP]
    neuron migration [UNKNOWN][IEA]
    locomotory behavior [UNKNOWN][IEA]
    negative regulation of epithelial to mesenchymal transition [UNKNOWN][IEA]
    positive regulation of transcription, DNA-dependent [UNKNOWN][IDA]
    neuron fate commitment [UNKNOWN]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    lung development [UNKNOWN]
    oligodendrocyte differentiation [UNKNOWN][IEA]
    lung saccule development [UNKNOWN][IEA]
    development of primary female sexual characteristics [IEP]
    regulation of transcription, DNA-dependent [UNKNOWN]
    pattern specification process [UNKNOWN][IEA]
    anatomical structure formation involved in morphogenesis [UNKNOWN][IEA]
    hippocampus development [UNKNOWN][IEA]
    brain development [UNKNOWN][IEA]
    response to hormone stimulus [UNKNOWN][IEA]
    Type II pneumocyte differentiation [UNKNOWN][IEA]
    organ morphogenesis [UNKNOWN][IEA]
    pituitary gland development [UNKNOWN][IEA]
    thyroid gland development [UNKNOWN][IEA]
    positive regulation of gene expression [UNKNOWN][IEA]
    response to lipopolysaccharide [IDA]
    developmental induction [UNKNOWN][IEA]
    Leydig cell differentiation [UNKNOWN][IEA]
    negative regulation of cell migration [UNKNOWN][IEA]
    negative regulation of transforming growth factor beta receptor signaling pathway [UNKNOWN][IEA]
    Molecular Function: DNA binding [UNKNOWN][IDA][TAS]
    transcription factor activity [UNKNOWN][IDA]
    protein binding [UNKNOWN][IPI]
    transcription regulator activity [UNKNOWN]
    specific RNA polymerase II transcription factor activity [UNKNOWN][IEA]
    RNA polymerase II transcription factor activity, enhancer binding [UNKNOWN][IEA]
    sequence-specific DNA binding [UNKNOWN][IDA]
    promoter binding [UNKNOWN][IEA]
    transcription activator activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSMSPKHTTP FSVSDILSPL EESYKKVGME GGGLGAPLAA YRQGQAAPPA AAMQQHAVGH  60
   61 HGAVTAAYHM TAAGVPQLSH SAVGGYCNGN LGNMSELPPY QDTMRNSASG PGWYGANPDP 120
  121 RFPAISRFMG PASGMNMSGM GGLGSLGDVS KNMAPLPSAP RRKRRVLFSQ AQVYELERRF 180
  181 KQQKYLSAPE REHLASMIHL TPTQVKIWFQ NHRYKMKRQA KDKAAQQQLQ QDSGGGGGGG 240
  241 GGAGCPQQQQ AQQQSPRRVA VPVLVKDGKP CQAGAPAPGA ASLQGHAQQQ AQQQAQAAQA 300
  301 AAAAISVGSG GAGLGAHPGH QPGSAGQSPD LAHHAASPAA LQGQVSSLSH LNSSGSDYGA 360
  361 MSCSTLLYGR TW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.74

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle