Protein Overview: IGF1R_RAT

General Information:
Name(s) found:	IGF1R_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|460334\|gb\|AAA41392.1\| insulin-like growth factor I receptor [Rattus norvegicus] [NCBI NR] gi\|2827762\|sp\|P24062.2\|IGF1R_RAT RecName: Full=Insulin-like growth factor 1 receptor; AltName: Full=Insulin-like growth factor I receptor; Short=IGF-I receptor; AltName: CD_antigen=CD221; Contains: RecName: Full=Insulin-like growth factor 1 receptor alpha [NCBI NR] gi\|16258823\|ref\|NP_434694.1\| insulin-like growth factor 1 receptor [Rattus norvegicus] [NCBI NR] Insulin-like growth factor 1 receptor OS=Rattus norvegicus GN=Igf1r PE=2 SV=2 [Swiss-Prot] (P24062) Insulin-like growth factor I receptor precursor (EC 2.7.1.112) [Swiss-Prot] Ensembl_locations(Chr-bp):1-119351155;1-119351155 Insulin-like growth factor I receptor precursor [hmr_yeast5_DM3-1_pombe.fasta] insulin-like growth factor 1 receptor [HMR_022704-rand.fasta] insulin-like growth factor 1 receptor [Rattus norvegicus]gi\|460334\|gb\|AAA41392.1\| insulin-like growth factor I receptor [Rattus norvegicus]gi\|2827762\|sp\|P24062\|IG1R_RAT Insulin-like growth factor I receptor precursor [nrdb_11152004_Chlamydomonas] (NM_052807) insulin-like growth factor 1 receptor [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] insulin-like growth factor I receptor [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Insulin-like growth factor 1 receptor precursor (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] insulin-like growth factor 1 receptor [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Insulin-like growth factor 1 receptor OS=Rattus norvegicus GN=Igf1r [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	1370 amino acids
Gene Ontology:
Cellular Component:	caveola [IDA] membrane [UNKNOWN] microsome [UNKNOWN][IEA] integral to membrane [IEA] neuron projection [IDA] plasma membrane [UNKNOWN][IEA]
Biological Process:	prostate gland epithelium morphogenesis [UNKNOWN][IEA] negative regulation of MAPKKK cascade [UNKNOWN][IEA] protein amino acid autophosphorylation [UNKNOWN][ISS] positive regulation of DNA replication [UNKNOWN][IEA] protein heterooligomerization [IDA] protein amino acid phosphorylation [UNKNOWN] positive regulation of anti-apoptosis [IMP] immune response [UNKNOWN][IEA] axonogenesis [IMP] protein tetramerization [UNKNOWN][ISS] exocrine pancreas development [UNKNOWN][IEA] positive regulation of cytokinesis [IMP] neuron projection development [IDA] response to vitamin E [IEP] insulin-like growth factor receptor signaling pathway [UNKNOWN][ISS] brain development [UNKNOWN][IEA] positive regulation of MAPKKK cascade [UNKNOWN][IEA] organ morphogenesis [UNKNOWN][IEA] male sex determination [UNKNOWN][IEA] mammary gland development [UNKNOWN][IEA] phosphoinositide-mediated signaling [UNKNOWN][IEA] positive regulation of DNA metabolic process [IMP] establishment of cell polarity [IMP] positive regulation of protein kinase B signaling cascade [UNKNOWN][IEA] positive regulation of cell migration [UNKNOWN][IEA] negative regulation of protein kinase B signaling cascade [UNKNOWN][IEA]
Molecular Function:	phosphoinositide 3-kinase binding [UNKNOWN][ISS] insulin binding [UNKNOWN][IEA] identical protein binding [UNKNOWN][IEA] insulin-like growth factor receptor activity [UNKNOWN][ISS][TAS] receptor activity [IEA] insulin receptor binding [UNKNOWN][IEA] insulin-like growth factor binding [UNKNOWN][ISS][TAS] nucleotide binding [IEA] ATP binding [IEA] protein tyrosine kinase activity [UNKNOWN][ISS] protein binding [UNKNOWN] metal ion binding [IEA] insulin receptor substrate binding [UNKNOWN][IPI][ISS] transferase activity [IEA] insulin-like growth factor I binding [UNKNOWN][IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSGSGGGSP TSLWGLVFLS AALSLWPTSG EICGPGIDIR NDYQQLKRLE NCTVIEGFLH  60
   61 ILLISKAEDY RSYRFPKLTV ITEYLLLFRV AGLESLGDLF PNLTVIRGWK LFYNYALVIF 120
  121 EMTNLKDIGL YNLRNITRGA IRIEKNADLC YLSTIDWSLI LDAVSNNYIV GNKPPKECGD 180
  181 LCPGTLEEKP MCEKTTINNE YNYRCWTTNR CQKMCPSVCG KRACTENNEC CHPECLGSCH 240
  241 TPDDNTTCVA CRHYYYKGVC VPACPPGTYR FEGWRCVDRD FCANIPNAES SDSDGFVIHD 300
  301 GECMQECPSG FIRNSTQSMY CIPCEGPCPK VCGDEEKKTK TIDSVTSAQM LQGCTILKGN 360
  361 LLINIRRGNN IASELENFMG LIEVVTGYVK IRHSHALVSL SFLKNLRLIL GEEQLEGNYS 420
  421 FYVLDNQNLQ QLWDWNHRNL TVRSGKMYFA FNPKLCVSEI YRMEEVTGTK GRQSKGDINT 480
  481 RNNGERASCE SDVLRFTSTT TWKNRIIITW HRYRPPDYRD LISFTVYYKE APFKNVTEYD 540
  541 GQDACGSNSW NMVDVDLPPN KEGEPGILLH GLKPWTQYAV YVKAVTLTMV ENDHIRGAKS 600
  601 EILYIRTNAS VPSIPLDVLS ASNSSSQLIV KWNPPTLPNG NLSYYIVRWQ RQPQDGYLFR 660
  661 HNYCSKDKIP IRKYADGTID VEEVTENPKT EVCGGDKGPC CACPKTEAEK QAEKEEAEYR 720
  721 KVFENFLHNS IFVPRPERRR RDVLQVANTT MSSRSRNTTV ADTYNITDPE EFETEYPFFE 780
  781 SRVDNKERTV ISNLRPFTLY RIDIHSCNHE AEKLGCSASN FVFARTMPAE GADDIPGPVT 840
  841 WEPRPENSIF LKWPEPENPN GLILMYEIKY GSQVEDQREC VSRQEYRKYG GAKLNRLNPG 900
  901 NYTARIQATS LSGNGSWTDP VFFYVPAKTT YENFMHLIIA LPVAILLIVG GLVIMLYVFH 960
  961 RKRNNSRLGN GVLYASVNPE YFSAADVYVP DEWEVAREKI TMNRELGQGS FGMVYEGVAK1020
 1021 GVVKDEPETR VAIKTVNEAA SMRERIEFLN EASVMKEFNC HHVVRLLGVV SQGQPTLVIM1080
 1081 ELMTRGDLKS YLRSLRPEVE NNLVLIPPSL SKMIQMAGEI ADGMAYLNAN KFVHRDLAAR1140
 1141 NCMVAEDFTV KIGDFGMTRD IYETDYYRKG GKGLLPVRWM SPESLKDGVF TTHSDVWSFG1200
 1201 VVLWEIATLA EQPYQGLSNE QVLRFVMEGG LLDKPDNCPD MLFELMRMCW QYNPKMRPSF1260
 1261 LEIIGSIKDE MEPSFQEVSF YYSEENKPPE PEELEMELEL EPENMESVPL DPSASSASLP1320
 1321 LPERHSGHKA ENGPGVLVLR ASFDERQPYA HMNGGRANER ALPLPQSSTC

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: IGF1R_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: